FARP2

FARP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GYV, 4GZU
Identifiers
Aliases	FARP2, FIR, FRG, PLEKHC3, FERM, ARH/RhoGEF and pleckstrin domain protein 2
External IDs	OMIM: 617586; MGI: 2385126; HomoloGene: 8877; GeneCards: FARP2; OMA:FARP2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,494,841 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,549,698 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; sural nerve; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; skin of leg; ; skin of abdomen; ; rectum; ; mucosa of sigmoid colon; ; mucosa of transverse colon;
	Top expressed in
	fossa; ; calvaria; ; primary oocyte; ; zygote; ; retinal pigment epithelium; ; left lobe of liver; ; secondary oocyte; ; epithelium of lens; ; body of femur; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytosol; cytoskeleton; cytoplasm;
Biological process	osteoclast differentiation; neuron remodeling; actin cytoskeleton reorganization; regulation of integrin activation; podosome assembly; cell adhesion; Rac protein signal transduction; regulation of Rho protein signal transduction; semaphorin-plexin signaling pathway; hair cycle process;
	Sources:Amigo / QuickGO
Orthologs
	9855
	227377
	ENSG00000006607
	ENSMUSG00000034066
	O94887
	Q91VS8
	NM_001282983; NM_001282984; NM_014808
	NM_145519
	NP_001269912; NP_001269913; NP_055623
	NP_663494
	Wikidata
View/Edit Human	View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 2 is a protein that in humans is encoded by the FARP2 gene.^[5]^[6]^[7]

Interactions

FARP2 has been shown to interact with PDZK1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.277-86&rft.date=1998-10&rft_id=info:doi/10.1093/dnares/5.5.277&rft_id=info:pmid/9872452&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa, K&rft.au=Suyama, M&rft.au=Kikuno, R&rft.au=Miyajima, N&rft.au=Tanaka, A&rft.au=Kotani, H&rft.au=Nomura, N&rft.au=Ohara, O&rft_id=https://doi.org/10.1093%2Fdnares%2F5.5.277&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">
^ Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC 6757789. PMID 12351724.8504-13&rft.date=2002-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757789#id-name=PMC&rft_id=info:pmid/12351724&rft_id=info:doi/10.1523/JNEUROSCI.22-19-08504.2002&rft.aulast=Kubo&rft.aufirst=T&rft.au=Yamashita, T&rft.au=Yamaguchi, A&rft.au=Sumimoto, H&rft.au=Hosokawa, K&rft.au=Tohyama, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757789&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">
^ "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".
^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.1733-45&rft.date=2003-11&rft_id=info:doi/10.1046/j.1523-1755.2003.00266.x&rft_id=info:pmid/14531806&rft.aulast=Gisler&rft.aufirst=SM&rft.au=Pribanic, S&rft.au=Bacic, D&rft.au=Forrer, P&rft.au=Gantenbein, A&rft.au=Sabourin, LA&rft.au=Tsuji, A&rft.au=Zhao, ZS&rft.au=Manser, E&rft.au=Biber, J&rft.au=Murer, H&rft_id=https://doi.org/10.1046%2Fj.1523-1755.2003.00266.x&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">

External links

Overview of all the structural information available in the PDB for UniProt: Q91VS8 (FERM, ARHGEF and pleckstrin domain-containing protein 2) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006607 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034066 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.277-86&rft.date=1998-10&rft_id=info:doi/10.1093/dnares/5.5.277&rft_id=info:pmid/9872452&rft.aulast=Nagase&rft.aufirst=T&rft.au=Ishikawa, K&rft.au=Suyama, M&rft.au=Kikuno, R&rft.au=Miyajima, N&rft.au=Tanaka, A&rft.au=Kotani, H&rft.au=Nomura, N&rft.au=Ohara, O&rft_id=https://doi.org/10.1093%2Fdnares%2F5.5.277&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">

[pmid12351724-6] Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M (Oct 2002). "A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling". The Journal of Neuroscience. 22 (19): 8504–13. doi:10.1523/JNEUROSCI.22-19-08504.2002. PMC 6757789. PMID 12351724.8504-13&rft.date=2002-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757789#id-name=PMC&rft_id=info:pmid/12351724&rft_id=info:doi/10.1523/JNEUROSCI.22-19-08504.2002&rft.aulast=Kubo&rft.aufirst=T&rft.au=Yamashita, T&rft.au=Yamaguchi, A&rft.au=Sumimoto, H&rft.au=Hosokawa, K&rft.au=Tohyama, M&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757789&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">

[entrez-7] "Entrez Gene: FARP2 FERM, RhoGEF and pleckstrin domain protein 2".

[pmid14531806-8] Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.1733-45&rft.date=2003-11&rft_id=info:doi/10.1046/j.1523-1755.2003.00266.x&rft_id=info:pmid/14531806&rft.aulast=Gisler&rft.aufirst=SM&rft.au=Pribanic, S&rft.au=Bacic, D&rft.au=Forrer, P&rft.au=Gantenbein, A&rft.au=Sabourin, LA&rft.au=Tsuji, A&rft.au=Zhao, ZS&rft.au=Manser, E&rft.au=Biber, J&rft.au=Murer, H&rft_id=https://doi.org/10.1046%2Fj.1523-1755.2003.00266.x&rfr_id=info:sid/en.wikipedia.org:FARP2" class="Z3988">

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

FARP2

Contents

Interactions

See also

References

Further reading

External links