In molecular biology, CagZ is a protein produced by Helicobacter pylori (Campylobacter pylori). It is a 23 kDa protein consisting of a single compact L-shaped domain, composed of seven alpha-helices that run antiparallel to each other. 70% of the amino acids are in alpha-helix conformation and no beta-sheet is present. CagZ is essential for the translocation of the pathogenic protein CagA into host cells.[1]
| CagZ | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of cag-z from helicobacter pylori | |||||||||
| Identifiers | |||||||||
| Symbol | CagZ | ||||||||
| Pfam | PF09053 | ||||||||
| InterPro | IPR015139 | ||||||||
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References
edit- ^ Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G (July 2004). "Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system". J. Mol. Biol. 340 (4): 881–9. doi:10.1016/j.jmb.2004.05.016. PMID 15223328.