Collagen, type IV, alpha 2

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.

COL4A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LI1
Identifiers
Aliases	COL4A2, ICH, POREN2, collagen type IV alpha 2, collagen type IV alpha 2 chain, BSVD2
External IDs	OMIM: 120090; MGI: 88455; HomoloGene: 1390; GeneCards: COL4A2; OMA:COL4A2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q34 Start 110,305,812 bp End 110,513,209 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 A1.1|8 5.62 cM Start 11,362,805 bp End 11,499,287 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein decidua pericardium visceral pleura stromal cell of endometrium urethra right coronary artery ascending aorta left coronary artery Descending thoracic aorta Top expressed in epithelium of lens left lung lobe external carotid artery internal carotid artery lactiferous gland stroma of bone marrow ascending aorta umbilical cord decidua aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent protein binding extracellular matrix structural constituent conferring tensile strength Cellular component extracellular matrix extracellular region basement membrane collagen collagen type IV trimer endoplasmic reticulum lumen extracellular exosome extracellular space collagen-containing extracellular matrix Biological process collagen catabolic process negative regulation of angiogenesis cellular response to transforming growth factor beta stimulus extracellular matrix organization endodermal cell differentiation angiogenesis transcription, DNA-templated collagen-activated tyrosine kinase receptor signaling pathway ageing response to activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1284 12827 Ensembl ENSG00000134871 ENSMUSG00000031503 UniProt P08572 P08122 RefSeq (mRNA) NM_001846 NM_009932 RefSeq (protein) NP_001837 NP_034062 Location (UCSC) Chr 13: 110.31 – 110.51 Mb Chr 8: 11.36 – 11.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Further reading

• Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein". Cell Adhes. Commun. 2 (3): 185–93. doi:10.3109/15419069409004436. PMID 7827955.
• Ständer M, Naumann U, Wick W, Weller M (1999). "Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth". Cell Tissue Res. 296 (2): 221–7. doi:10.1007/s004410051283. PMID 10382266. S2CID 20282995.
• Kurpakus Wheater M, Kernacki KA, Hazlett LD (1999). "Corneal cell proteins and ocular surface pathology". Biotechnic & Histochemistry. 74 (3): 146–59. doi:10.3109/10520299909047967. PMID 10416788.
• Kalluri R, Sukhatme VP (2000). "Fibrosis and angiogenesis". Curr. Opin. Nephrol. Hypertens. 9 (4): 413–8. doi:10.1097/00041552-200007000-00013. PMID 10926178.
• Ghebrehiwet B, Peerschke EI, Hong Y, et al. (1992). "Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV". J. Leukoc. Biol. 51 (6): 546–56. doi:10.1002/jlb.51.6.546. PMID 1377218. S2CID 1214598.
• Gupta S, Batchu RB, Datta K (1992). "Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface". Eur. J. Cell Biol. 56 (1): 58–67. PMID 1724753.
• Paralkar VM, Nandedkar AK, Pointer RH, et al. (1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". J. Biol. Chem. 265 (28): 17281–4. doi:10.1016/S0021-9258(17)44900-3. PMID 2211625.
• Hernandez MR, Igoe F, Neufeld AH (1986). "Extracellular matrix of the human optic nerve head". Am. J. Ophthalmol. 102 (2): 139–48. doi:10.1016/0002-9394(86)90134-0. PMID 2426947.
• Siebold B, Deutzmann R, Kühn K (1988). "The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen". Eur. J. Biochem. 176 (3): 617–24. doi:10.1111/j.1432-1033.1988.tb14321.x. PMID 2844531.
• Pöschl E, Pollner R, Kühn K (1988). "The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure". EMBO J. 7 (9): 2687–95. doi:10.1002/j.1460-2075.1988.tb03122.x. PMC 457057. PMID 2846280.
• Murata K, Motayama T, Kotake C (1986). "Collagen types in various layers of the human aorta and their changes with the atherosclerotic process". Atherosclerosis. 60 (3): 251–62. doi:10.1016/0021-9150(86)90172-3. PMID 3089234.
• Soininen R, Huotari M, Hostikka SL, et al. (1988). "The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region". J. Biol. Chem. 263 (33): 17217–20. doi:10.1016/S0021-9258(19)77818-1. PMID 3182844.
• Hostikka SL, Tryggvason K (1989). "The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain". J. Biol. Chem. 263 (36): 19488–93. doi:10.1016/S0021-9258(19)77660-1. PMID 3198637.
• Brazel D, Pollner R, Oberbäumer I, Kühn K (1988). "Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain". Eur. J. Biochem. 172 (1): 35–42. doi:10.1111/j.1432-1033.1988.tb13852.x. PMID 3345760.
• Hostikka SL, Kurkinen M, Tryggvason K (1987). "Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region". FEBS Lett. 216 (2): 281–6. doi:10.1016/0014-5793(87)80706-8. PMID 3582677.
• Killen PD, Francomano CA, Yamada Y, et al. (1988). "Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2)". Hum. Genet. 77 (4): 318–24. doi:10.1007/BF00291418. PMID 3692475. S2CID 11387376.
• Glant TT, Hadházy C, Mikecz K, Sipos A (1985). "Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II". Histochemistry. 82 (2): 149–58. doi:10.1007/bf00708199. PMID 3997552. S2CID 19401258.
• Uscanga L, Kennedy RH, Stocker S, et al. (1984). "Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas". Digestion. 30 (3): 158–64. doi:10.1159/000199100. PMID 6389236.