CEBPG

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene. This gene has no introns.

CEBPG
Identifiers
Aliases	CEBPG, GPE1BP, IG/EBP-1, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein gamma
External IDs	OMIM: 138972; MGI: 104982; HomoloGene: 1368; GeneCards: CEBPG; OMA:CEBPG - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.11 Start 33,373,685 bp End 33,382,686 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B2 Start 34,745,847 bp End 34,755,998 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte mucosa of colon mucosa of sigmoid colon muscle of thigh middle temporal gyrus mucosa of transverse colon body of tongue gingival epithelium jejunum jejunal mucosa Top expressed in olfactory epithelium condyle parotid gland zygote conjunctival fornix lacrimal gland secondary oocyte seminal vesicula fossa left colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein homodimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding sequence-specific DNA binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific double-stranded DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Cellular component nucleoplasm nucleus Biological process regulation of transcription, DNA-templated positive regulation of DNA repair positive regulation of DNA-binding transcription factor activity negative regulation of DNA-binding transcription factor activity transcription, DNA-templated enucleate erythrocyte differentiation immune response mRNA metabolic process B cell differentiation positive regulation of DNA binding positive regulation of transcription by RNA polymerase II natural killer cell mediated cytotoxicity transcription by RNA polymerase II liver development regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1054 12611 Ensembl ENSG00000153879 ENSMUSG00000056216 UniProt P53567 P53568 RefSeq (mRNA) NM_001806 NM_001252296 NM_009884 RefSeq (protein) NP_001239225 NP_001797 NP_034014 Location (UCSC) Chr 19: 33.37 – 33.38 Mb Chr 7: 34.75 – 34.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPζ, and C/EBPε, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind the positive regulatory element-I (PRE-I) enhancer elements.

C/EBPγ forms heterodimer with ATF4 for transcriptional activation of target genes in autophagy specifically to amino acid starvation.

C/EBPγ along with its regulator, the trauma-induced transcription factor EGR1, plays an important role in the development of chronic pain and mechanical hypersensitivity after some types of injury or surgery.

Further reading

• Nishizawa M, Nagata S (March 1992). "cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein". FEBS Letters. 299 (1): 36–38. Bibcode:1992FEBSL.299...36N. doi:10.1016/0014-5793(92)80094-W. PMID 1371974. S2CID 34097395.
• Thomassin H, Hamel D, Bernier D, Guertin M, Belanger L (June 1992). "Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma". Nucleic Acids Research. 20 (12): 3091–3098. doi:10.1093/nar/20.12.3091. PMC 312443. PMID 1377818.
• Nishizawa M, Wakabayashi-Ito N, Nagata S (April 1991). "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1". FEBS Letters. 282 (1): 95–97. Bibcode:1991FEBSL.282...95N. doi:10.1016/0014-5793(91)80452-9. PMID 1709121. S2CID 948618.
• Cooper C, Henderson A, Artandi S, Avitahl N, Calame K (November 1995). "Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators". Nucleic Acids Research. 23 (21): 4371–4377. doi:10.1093/nar/23.21.4371. PMC 307392. PMID 7501458.
• Lundgren M, Larsson C, Femino A, Xu M, Stavnezer J, Severinson E (October 1994). "Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site". Journal of Immunology. 153 (7): 2983–2995. doi:10.4049/jimmunol.153.7.2983. PMID 8089482. S2CID 24982598.
• Martin ML, Lieberman PM, Curran T (May 1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF". Molecular and Cellular Biology. 16 (5): 2110–2118. doi:10.1128/mcb.16.5.2110. PMC 231198. PMID 8628277.
• Gao H, Parkin S, Johnson PF, Schwartz RC (October 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–38837. doi:10.1074/jbc.M206224200. PMID 12177065.
• Hattori T, Ohoka N, Inoue Y, Hayashi H, Onozaki K (March 2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer". Oncogene. 22 (9): 1273–1280. doi:10.1038/sj.onc.1206204. PMID 12618752. S2CID 1351748.
• Newman JR, Keating AE (June 2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–2101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mullins DN, Crawford EL, Khuder SA, Hernandez DA, Yoon Y, Willey JC (October 2005). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma". BMC Cancer. 5: 141. doi:10.1186/1471-2407-5-141. PMC 1310620. PMID 16255782.

External links

• CEBPG protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CEBPG genome location and CEBPG gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.