BMPR1A

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).

BMPR1A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QB4, 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH7
Identifiers
Aliases	BMPR1A, 10q23del, ACVRLK3, ALK3, CD292, SKR5, bone morphogenetic protein receptor type 1A
External IDs	OMIM: 601299; MGI: 1338938; HomoloGene: 20911; GeneCards: BMPR1A; OMA:BMPR1A - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q23.2 Start 86,756,601 bp End 86,932,825 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 B|14 20.81 cM Start 34,132,691 bp End 34,225,298 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon saphenous vein parotid gland tail of epididymis biceps brachii seminal vesicula popliteal artery tibial arteries urethra Top expressed in ascending aorta aortic valve vas deferens vestibular sensory epithelium efferent ductule genital tubercle calvaria epithelium of lens iris vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein homodimerization activity metal ion binding kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding DNA-binding transcription factor activity, RNA polymerase II-specific SMAD binding ATP binding BMP receptor activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I growth factor binding Cellular component integral component of membrane HFE-transferrin receptor complex membrane plasma membrane soma dendrite caveola external side of plasma membrane integral component of plasma membrane receptor complex cell surface Biological process somitogenesis pattern specification process roof of mouth development cell differentiation pituitary gland development endoderm development chondrocyte differentiation neural crest cell development lateral mesoderm development lung development positive regulation of bone mineralization embryonic organ development paraxial mesoderm structural organization positive regulation of epithelial cell proliferation phosphorylation negative regulation of neurogenesis positive regulation of pathway-restricted SMAD protein phosphorylation mesoderm formation ectoderm development embryonic digit morphogenesis heart morphogenesis cellular response to BMP stimulus in utero embryonic development BMP signaling pathway hindlimb morphogenesis nervous system development dorsal/ventral axis specification regulation of lateral mesodermal cell fate specification stem cell population maintenance odontogenesis of dentin-containing tooth Mullerian duct regression endocardial cushion formation protein phosphorylation positive regulation of transcription, DNA-templated heart development cartilage development positive regulation of osteoblast differentiation developmental growth transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of mesenchymal cell proliferation heart formation neural plate pattern specification embryonic morphogenesis mesendoderm development immune response regulation of cellular senescence neural plate mediolateral regionalization dorsal/ventral pattern formation transforming growth factor beta receptor signaling pathway positive regulation of SMAD protein signal transduction anterior/posterior pattern specification paraxial mesoderm development positive regulation of pri-miRNA transcription by RNA polymerase II negative regulation of smooth muscle cell migration BMP signaling pathway involved in heart development regulation of cardiac muscle cell apoptotic process outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis dorsal aorta morphogenesis positive regulation of transcription by RNA polymerase II regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation pharyngeal arch artery morphogenesis positive regulation of cardiac ventricle development positive regulation of vascular associated smooth muscle cell proliferation fibrous ring of heart morphogenesis regulation of neural crest cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 657 12166 Ensembl ENSG00000107779 ENSMUSG00000021796 UniProt P36894 P36895 RefSeq (mRNA) NM_004329 NM_009758 RefSeq (protein) NP_004320 NP_033888 Location (UCSC) Chr 10: 86.76 – 86.93 Mb Chr 14: 34.13 – 34.23 Mb PubMed search
Wikidata
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Function

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF beta superfamily. TGF-betas and activins transduce their signals through the formation of heterodimeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embryonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation. It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development. Using constitutively active forms of BMPR1A, it has been shown that BMPR1A plays a role in cell differentiation. Signals transduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix deposition by osteoblasts. In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis.

Ligands

• Agonists: BMP2, BMP4, BMP6, BMP7, GDF6
• Antagonists: Noggin, Chordin

Diseases

BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.

Interactions

BMPR1A has been shown to interact with:

• BMP2,
• SF3B4, and
• ZMYND11.

Further reading

• Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Mol. Cell. Biol. 15 (7): 3479–86. doi:10.1128/mcb.15.7.3479. PMC 230584. PMID 7791754.
• ten Dijke P, Ichijo H, Franzén P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K (1993). "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". Oncogene. 8 (10): 2879–87. PMID 8397373.
• Ishidou Y, Kitajima I, Obama H, Maruyama I, Murata F, Imamura T, Yamada N, ten Dijke P, Miyazono K, Sakou T (1996). "Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation". J. Bone Miner. Res. 10 (11): 1651–9. doi:10.1002/jbmr.5650101107. PMID 8592941. S2CID 33345688.
• Yamada N, Kato M, ten Dijke P, Yamashita H, Sampath TK, Heldin CH, Miyazono K, Funa K (1996). "Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours". Br. J. Cancer. 73 (5): 624–9. doi:10.1038/bjc.1996.108. PMC 2074358. PMID 8605097.
• Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K (1996). "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 (35): 21345–52. doi:10.1074/jbc.271.35.21345. PMID 8702914.
• Wu X, Robinson CE, Fong HW, Gimble JM (1996). "Analysis of the native murine bone morphogenetic protein serine threonine kinase type I receptor (ALK-3)". J. Cell. Physiol. 168 (2): 453–61. doi:10.1002/(SICI)1097-4652(199608)168:2<453::AID-JCP24>3.0.CO;2-2. PMID 8707881. S2CID 22669576.
• Erlacher L, McCartney J, Piek E, ten Dijke P, Yanagishita M, Oppermann H, Luyten FP (1998). "Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis". J. Bone Miner. Res. 13 (3): 383–92. doi:10.1359/jbmr.1998.13.3.383. PMID 9525338. S2CID 25307046.
• Zhang D, Mehler MF, Song Q, Kessler JA (1998). "Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression". J. Neurosci. 18 (9): 3314–26. doi:10.1523/JNEUROSCI.18-09-03314.1998. PMC 6792660. PMID 9547239.
• Ide H, Saito-Ohara F, Ohnami S, Osada Y, Ikeuchi T, Yoshida T, Terada M (1998). "Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23→q24 byin situ hybridization and radiation hybrid map ping". Cytogenet. Cell Genet. 81 (3–4): 285–6. doi:10.1159/000015048. PMID 9730621. S2CID 46751090.
• Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P (1998). "Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors". J. Biol. Chem. 273 (39): 25364–70. doi:10.1074/jbc.273.39.25364. PMID 9738003.
• You L, Kruse FE, Pohl J, Völcker HE (1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Invest. Ophthalmol. Vis. Sci. 40 (2): 296–311. PMID 9950587.
• Aström AK, Jin D, Imamura T, Röijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G (1999). "Chromosomal localization of three human genes encoding bone morphogenetic protein receptors". Mamm. Genome. 10 (3): 299–302. doi:10.1007/s003359900990. PMID 10051328. S2CID 19132542.
• Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell Sci. 112 (20): 3519–27. doi:10.1242/jcs.112.20.3519. PMID 10504300.
• Kim IY, Lee DH, Ahn HJ, Tokunaga H, Song W, Devereaux LM, Jin D, Sampath TK, Morton RA (2000). "Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues". Cancer Res. 60 (11): 2840–4. PMID 10850425.
• Kirsch T, Sebald W, Dreyer MK (2000). "Crystal structure of the BMP-2-BRIA ectodomain complex". Nat. Struct. Biol. 7 (6): 492–6. doi:10.1038/75903. PMID 10881198. S2CID 19403233.
• Wan M, Shi X, Feng X, Cao X (2001). "Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression". J. Biol. Chem. 276 (13): 10119–25. doi:10.1074/jbc.M006918200. PMID 11139569.

External links

• GeneReviews/NCBI/NIH/UW entry on Juvenile Polyposis Syndrome
• BMPR1A protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human BMPR1A genome location and BMPR1A gene details page in the UCSC Genome Browser.