Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]
Structure
editThe protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]
- N-terminus – PHD finger (C4HC3 zinc finger)
- WAKZ motif
- LH (leucine-rich helical domain) motif
- C-terminus – bromodomain
Function
editBAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]
The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]
Interactions
editBAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]
References
edit- ^ a b Jones MH, Hamana N, Nezu J, Shimane M (Apr 2000). "A novel family of bromodomain genes". Genomics. 63 (1): 40–5. doi:10.1006/geno.1999.6071. PMID 10662543.
- ^ "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A".
- ^ a b Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (February 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi:10.1073/pnas.97.3.1038. PMC 15513. PMID 10655480.
- ^ a b c Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (July 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450.
- ^ Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (December 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID 12434153. S2CID 22545162.
- ^ Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. 21 (9). England: 2231–41. doi:10.1093/emboj/21.9.2231. ISSN 0261-4189. PMC 125993. PMID 11980720.
- ^ a b Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907). England: 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. ISSN 0028-0836. PMID 12374985. S2CID 25822700.
- ^ Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. 418 (6901). England: 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550. S2CID 4344470.
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