Wikipedia

Acylation stimulating protein

Complement 3 (C3) through its interaction with factors B and D (adipsin) generates C3a. In the human body, C3a is rapidly cleaved by carboxypeptidase B or carbxyopeptidase N, that remove the carboxyl-terminal arginine to generate C3adesArg.[1] Thus, most of plasmatic C3a is present in C3adesArg form. C3adesArg is more commonly named ASP or acylation-stimulating-protein due to its marked stimulating action on triacylglycerol synthesis in human adipocytes and skin fibroblasts.[2] ASP is also known for its augmentation of glucose transport and inhibiting action on hormone-sensitive lipase. Because of these actions, it is linked to the pathogenesis of obesity,[3] having been demonstrated to be present at increased levels in patients with obesity,[4] diabetes mellitus type 2[5] and coronary artery disease.[6]

ASP lis a ligand for C5L2, a G-protein-coupled receptor.[7]

The view of C3a/C3adesArg as an acylation stimulating activity is not universally accepted. The evidence is discussed in a recent review.[8]

References

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  1. ^ Baldo et al. 1993, pp. 1543–1547
  2. ^ Cianflone et al., pp. 426–430
  3. ^ (Sniderman, Maslowska & Cianflone 2000, pp. 291–296)
  4. ^ Maslowska et al. 1999, pp. 679–686
  5. ^ Koistinen et al. 2001, pp. 1034–1039
  6. ^ Cianflone et al. 1997, pp. 1239–1244
  7. ^ Cui et al. 2009, pp. 3207–3217
  8. ^ Klos A, Wende E, Wareham KJ, Monk PN (2013). "International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacol. Rev. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.500-43&rft.date=2013&rft_id=info:doi/10.1124/pr.111.005223&rft_id=info:pmid/23383423&rft.aulast=Klos&rft.aufirst=A&rft.au=Wende, E&rft.au=Wareham, KJ&rft.au=Monk, PN&rft_id=https://doi.org/10.1124%2Fpr.111.005223&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">

Further reading

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  • Baldo, A; Sniderman, A D; St-Luce, S; Avramoglu, R K; Maslowska, M; Hoang, B; Monge, J C; Bell, A; Mulay, S; Cianflone, K (1993). "The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis". Journal of Clinical Investigation. 92 (3): 1543–1547. doi:10.1172/JCI116733. PMC 288301. PMID 8376604.1543-1547&rft.date=1993&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC288301#id-name=PMC&rft_id=info:pmid/8376604&rft_id=info:doi/10.1172/JCI116733&rft.aulast=Baldo&rft.aufirst=A&rft.au=Sniderman, A D&rft.au=St-Luce, S&rft.au=Avramoglu, R K&rft.au=Maslowska, M&rft.au=Hoang, B&rft.au=Monge, J C&rft.au=Bell, A&rft.au=Mulay, S&rft.au=Cianflone, K&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC288301&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Cianflone, Katherine M.; Sniderman, Allan D.; Walsh, Mark J.; Vu, Hai T.; Gagnon, Jean; Rodriguez, Miguel A. (1989). "Purification and Characterization of Acylation Stimulating Protein". The Journal of Biological Chemistry. 264 (1): 426–30. doi:10.1016/S0021-9258(17)31275-9. PMID 2909530.426-30&rft.date=1989&rft_id=info:doi/10.1016/S0021-9258(17)31275-9&rft_id=info:pmid/2909530&rft.aulast=Cianflone&rft.aufirst=Katherine M.&rft.au=Sniderman, Allan D.&rft.au=Walsh, Mark J.&rft.au=Vu, Hai T.&rft.au=Gagnon, Jean&rft.au=Rodriguez, Miguel A.&rft_id=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2909530&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Cianflone, K.; Zhang, XJ; Genest Jr, J; Sniderman, A (July 1997). "Plasma acylation-stimulating protein in coronary artery disease". Arterioscler Thromb Vasc Biol. 17 (7): 1239–44. doi:10.1161/ATVB.17v07.1239. PMID 9261252.1239-44&rft.date=1997-07&rft_id=info:doi/10.1161/ATVB.17v07.1239&rft_id=info:pmid/9261252&rft.aulast=Cianflone&rft.aufirst=K.&rft.au=Zhang, XJ&rft.au=Genest Jr, J&rft.au=Sniderman, A&rft_id=https://doi.org/10.1161%2FATVB.17v07.1239&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Cui, Wei; Lapointe, Marc; Gauvreau, Danny; Kalant, David; Cianflone, Katherine (October 2009). "Recombinant C3adesArg/acylation stimulating protein (ASP) is highly bioactive: a critical evaluation of C5L2 binding and 3T3-L1 adipocyte activation". Mol Immunol. 46 (16): 3207–17. doi:10.1016/j.molimm.2009.08.013. PMID 19767107.3207-17&rft.date=2009-10&rft_id=info:doi/10.1016/j.molimm.2009.08.013&rft_id=info:pmid/19767107&rft.aulast=Cui&rft.aufirst=Wei&rft.au=Lapointe, Marc&rft.au=Gauvreau, Danny&rft.au=Kalant, David&rft.au=Cianflone, Katherine&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Sniderman, Allan D.; Maslowska, Magdalena; Cianflone, Katherine (2000). "Of mice and men (and women) and the acylation-stimulating protein pathway". Current Opinion in Lipidology. 11 (3): 291–6. doi:10.1097/00041433-200006000-00010. PMID 10882345.291-6&rft.date=2000&rft_id=info:doi/10.1097/00041433-200006000-00010&rft_id=info:pmid/10882345&rft.aulast=Sniderman&rft.aufirst=Allan D.&rft.au=Maslowska, Magdalena&rft.au=Cianflone, Katherine&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Maslowska, M; Vu, H; Phelis, S; Sniderman, AD; Rhode, BM; Blank, D; Cianflone, K (1999). "Plasma acylation stimulating protein, adipsin and lipids in non-obese and obese populations". European Journal of Clinical Investigation. 29 (8): 679–86. doi:10.1046/j.1365-2362.1999.00514.x. PMID 10457151. S2CID 19694467.679-86&rft.date=1999&rft_id=https://api.semanticscholar.org/CorpusID:19694467#id-name=S2CID&rft_id=info:pmid/10457151&rft_id=info:doi/10.1046/j.1365-2362.1999.00514.x&rft.aulast=Maslowska&rft.aufirst=M&rft.au=Vu, H&rft.au=Phelis, S&rft.au=Sniderman, AD&rft.au=Rhode, BM&rft.au=Blank, D&rft.au=Cianflone, K&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
  • Koistinen, Heikki A.; Vidal, Hubert; Karonen, Sirkka-Liisa; Dusserre, Eric; Vallier, Paulette; Koivisto, Veikko A.; Ebeling, Pertti (2001). "Plasma Acylation Stimulating Protein Concentration and Subcutaneous Adipose Tissue C3 mRNA Expression in Nondiabetic and Type 2 Diabetic Men". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (6): 1034–9. doi:10.1161/01.atv.21.6.1034. PMID 11397716.1034-9&rft.date=2001&rft_id=info:doi/10.1161/01.atv.21.6.1034&rft_id=info:pmid/11397716&rft.aulast=Koistinen&rft.aufirst=Heikki A.&rft.au=Vidal, Hubert&rft.au=Karonen, Sirkka-Liisa&rft.au=Dusserre, Eric&rft.au=Vallier, Paulette&rft.au=Koivisto, Veikko A.&rft.au=Ebeling, Pertti&rft_id=https://doi.org/10.1161%2F01.atv.21.6.1034&rfr_id=info:sid/en.wikipedia.org:Acylation stimulating protein" class="Z3988">
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