ASAH2

Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.

ASAH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WGK
Identifiers
Aliases	ASAH2, BCDase, HNAC1, LCDase, N-CDase, NCDase, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2, N-acylsphingosine amidohydrolase 2
External IDs	OMIM: 611202; MGI: 1859310; HomoloGene: 10310; GeneCards: ASAH2; OMA:ASAH2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q11.23 Start 50,182,778 bp End 50,279,720 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C1 Start 31,959,997 bp End 32,085,611 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum gonad testicle stromal cell of endometrium islet of Langerhans smooth muscle tissue ganglionic eminence muscle of thigh tonsil skeletal muscle tissue Top expressed in epithelium of small intestine intestinal villus jejunum lacrimal gland duodenum esophagus parotid gland Epithelium of choroid plexus deep cerebellar nuclei motor neuron More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity ceramidase activity calcium ion binding zinc ion binding N-acylsphingosine amidohydrolase activity metal ion binding Cellular component integral component of membrane plasma membrane membrane mitochondrion extracellular region Biological process lipid metabolism sphingolipid metabolic process apoptotic process sphingosine metabolic process ceramide metabolic process response to organic substance long-chain fatty acid biosynthetic process sphingosine biosynthetic process ceramide catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56624 54447 Ensembl ENSG00000188611 ENSMUSG00000024887 UniProt Q9NR71 Q9JHE3 RefSeq (mRNA) NM_001143974 NM_019893 NM_018830 RefSeq (protein) NP_001137446 NP_063946 NP_061300 Location (UCSC) Chr 10: 50.18 – 50.28 Mb Chr 19: 31.96 – 32.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

External links

• Human ASAH2 genome location and ASAH2 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9NR71 (Neutral ceramidase; ASAH2) at the PDBe-KB.

Further reading

• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Tani M, Okino N, Mori K, et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases". J. Biol. Chem. 275 (15): 11229–34. doi:10.1074/jbc.275.15.11229. PMID 10753931.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Choi MS, Anderson MA, Zhang Z, et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene. 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Monick MM, Mallampalli RK, Bradford M, et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity". J. Immunol. 173 (1): 123–35. doi:10.4049/jimmunol.173.1.123. PMID 15210766.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hwang YH, Tani M, Nakagawa T, et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
• Osawa Y, Uchinami H, Bielawski J, et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 18636935.
• Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
• Galadari S, Wu BX, Mao C, et al. (2006). "Identification of a novel amidase motif in neutral ceramidase". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686.
• Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. S2CID 20973940.
• Avramopoulos D, Wang R, Valle D, et al. (2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805. S2CID 20156514.
• Ohlsson L, Palmberg C, Duan RD, et al. (2007). "Purification and characterization of human intestinal neutral ceramidase". Biochimie. 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390.