Yan Kugel
Illertissen, Bayern, Deutschland
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🚀𝐄𝐧𝐝 𝐭𝐡𝐞 𝐘𝐞𝐚𝐫 𝐨𝐧 𝐚 𝐇𝐢𝐠𝐡! 📢 🔔Missed any of our webinars, this year? Fret Not! 🎙Now, you can access all our past…
🚀𝐄𝐧𝐝 𝐭𝐡𝐞 𝐘𝐞𝐚𝐫 𝐨𝐧 𝐚 𝐇𝐢𝐠𝐡! 📢 🔔Missed any of our webinars, this year? Fret Not! 🎙Now, you can access all our past…
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🎤 Excited for PharmaLab Congress 2024, where I'll be presenting on Risk-Based Qualification of HPLC Systems! Join us to explore how risk-based…
🎤 Excited for PharmaLab Congress 2024, where I'll be presenting on Risk-Based Qualification of HPLC Systems! Join us to explore how risk-based…
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Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Nanotechnology holds great promise for a plethora of potential applications. The interaction of engineered nanomaterials with living cells, tissues, and organisms is, however, only partly understood. Microscopic investigations of nano-bio interactions are mostly performed with a few model nanoparticles (NPs) which are easy to visualize, such as fluorescent quantum dots. Here the possibility to visualize nonfluorescent NPs with multiphoton excitation is investigated. Signals from silver (Ag)…
Nanotechnology holds great promise for a plethora of potential applications. The interaction of engineered nanomaterials with living cells, tissues, and organisms is, however, only partly understood. Microscopic investigations of nano-bio interactions are mostly performed with a few model nanoparticles (NPs) which are easy to visualize, such as fluorescent quantum dots. Here the possibility to visualize nonfluorescent NPs with multiphoton excitation is investigated. Signals from silver (Ag), titanium dioxide (TiO2), and silica (SiO2) NPs in nonbiological environments are characterized to determine signal dependency on excitation wavelength and intensity as well as their signal stability over time. Ag NPs generate plasmon-induced luminescence decaying over time. TiO2 NPs induce photoluminescent signals of variable intensities and in addition strong third harmonic generation (THG). Optimal settings for microscopic detection are determined and then applied for visualization of these two particle types in living cells, in murine muscle tissue, and in the murine blood stream. Silica NPs produce a THG signal, but in living cells it cannot be discriminated sufficiently from endogenous cellular structures. It is concluded that multiphoton excitation is a viable option for studies of nano-bio interactions not only for fluorescent but also for some types of nonfluorescent NPs.
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Weitere Aktivitäten von Yan Kugel
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🚀𝐑𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐞𝐱𝐩𝐞𝐫𝐭𝐬 𝐈 𝐦𝐞𝐭 𝐚𝐭 𝐚 𝐫𝐞𝐜𝐞𝐧𝐭 𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐝𝐢𝐬𝐜𝐮𝐬𝐬𝐞𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐚…
🚀𝐑𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐞𝐱𝐩𝐞𝐫𝐭𝐬 𝐈 𝐦𝐞𝐭 𝐚𝐭 𝐚 𝐫𝐞𝐜𝐞𝐧𝐭 𝐜𝐨𝐧𝐟𝐞𝐫𝐞𝐧𝐜𝐞 𝐝𝐢𝐬𝐜𝐮𝐬𝐬𝐞𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐜𝐞 𝐨𝐟 𝐚…
Veröffentlicht von Yan Kugel
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Getting ready here at #RQA2024! Looking forward to a great conference! 🤩 If you are here come and say hi!👋…
Getting ready here at #RQA2024! Looking forward to a great conference! 🤩 If you are here come and say hi!👋…
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So I learned a new phrase at the RQA conference to describe what we do! Apparently we are “Fractional QPs” Feel free to call to stand 20 and meet…
So I learned a new phrase at the RQA conference to describe what we do! Apparently we are “Fractional QPs” Feel free to call to stand 20 and meet…
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We are live from Gulfood Manufacturing! Day 2 is underway. Don't miss the chance to meet our Sales Team and know more in detail our latest…
We are live from Gulfood Manufacturing! Day 2 is underway. Don't miss the chance to meet our Sales Team and know more in detail our latest…
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We are traveling to the RQA international conference in Brighton. Our first stop is central London for a lovely lunch and strategy session with our…
We are traveling to the RQA international conference in Brighton. Our first stop is central London for a lovely lunch and strategy session with our…
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𝐃𝐨 𝐲𝐨𝐮 𝐤𝐧𝐨𝐰 𝐰𝐡𝐲 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐨𝐯𝐢𝐠𝐢𝐥𝐚𝐧𝐜𝐞 𝐢𝐬 𝐬𝐨 𝐜𝐫𝐢𝐭𝐢𝐜𝐚𝐥? 👇 Check out what all it entails 🔜…
𝐃𝐨 𝐲𝐨𝐮 𝐤𝐧𝐨𝐰 𝐰𝐡𝐲 𝐏𝐡𝐚𝐫𝐦𝐚𝐜𝐨𝐯𝐢𝐠𝐢𝐥𝐚𝐧𝐜𝐞 𝐢𝐬 𝐬𝐨 𝐜𝐫𝐢𝐭𝐢𝐜𝐚𝐥? 👇 Check out what all it entails 🔜…
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Looking forward to delivering our Advanced Autoclave Validation course next week!
Looking forward to delivering our Advanced Autoclave Validation course next week!
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