Great to see this published!! Congrats to our collaborators at Bayer and the DKFZ, in particular Gabriele Leder, Jeffrey Mowat and Rienk Offringa! MAP4K1 (also known as HPK1) is a an attractive immune-oncology target for inducing therapeutic T-cell responses in cancer patients! OmicScouts is proud of contributing to this excellent study, in which our KinomeScout™ technology enabled selectivity profiling of the lead compound BAY-405 across cellular kinases of relevant biological systems! Read more about our KinomeScout assay here: https://lnkd.in/dgpTRvGr #Bayer #DrugDiscovery #Proteomics
Our publication on the discovery of BAY-405, an azaindole-based MAP4K1 inhibitor for the enhancement of T-cell immunity against cancer is out now! This work covers our journey from initial screening through to comprehensive in-vivo profiling, showcasing the SAR and optimization of a unique oxazine motif. Thanks to Rienk Offringa, Gabriele Leder, Rafael Carretero, Judith Günther, and Hideki Miyatake for their hard work and perseverance on this manuscript. https://lnkd.in/eSjCfjDx