We are excited to announce 📣 the launch of our new DynamicOrgan System! The open organ-on-chip platform You can now build human in vitro disease and infection models with the DynamicOrgan System. A system that includes pumps, biochips, consumables, and the freedom to keep using standard laboratory equipment. / No capex spending / No need for specialized equipment / Work with equipment you already have / Works with established standards / Easy access to training / Scalable sample number & tissue complexity Learn more here: https://lnkd.in/gVFF3UiW #DynamicOrgan #organonchip
Dynamic42 GmbH
Biotechnologieforschung
Jena, Thüringen 2.306 Follower:innen
Develop human organ models with true physiological complexity
Info
We are specialized in the production and development of human, immunocompetent Organ-on-Chip technology for in vitro disease and infection modelling.
- Website
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http://www.dynamic42.com
Externer Link zu Dynamic42 GmbH
- Branche
- Biotechnologieforschung
- Größe
- 11–50 Beschäftigte
- Hauptsitz
- Jena, Thüringen
- Art
- Privatunternehmen
- Gegründet
- 2018
- Spezialgebiete
- Organ-on-Chip, Human Cell Biology, Infection, Infectious disease, Toxicity profiling, Immune Cell Interactions, Inflammatory Diseases, Antibody recycling und Uptake / Transport studies
Orte
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Primär
Winzerlaer Straße 2
Jena, Thüringen 07745, DE
Beschäftigte von Dynamic42 GmbH
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Alexander Mosig
Cell biologist dedicated to engineering
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Dr. Juliane Fischer
Marketing Manager / Scientist by training / With a passion for Marketing in Biotech
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Dr. Japhette E. Kembou-Ringert
Molecular Virologist | Senior Scientist | Passionate about Fundamental Virology and its Principles | Recent interests also include Organ-On-Chip and…
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Andreas Pöbel
Working in the field of Organ on Chip | Liver on Chip | Change Drug Testing
Updates
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Dynamic42 GmbH hat dies direkt geteilt
Following a constructive kick-off meeting with the German Federal Institute for Drugs and Medical Devices (BfArM), the largest drug regulatory authority in Europe, PRAMOMOLECULAR is proud to now enter preclinical development together with the Charité Comprehensive Cancer Center (CCCC) of PRAMO's first drug candidate against a form of non-small cell lung cancer (#NSCLC) that is currently not amenable to targeted therapy.
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Why does the adsorption of compounds by the biochip materials we use matter? In a recent webinar, we discussed in depth why the materials used for organ-on-chip models matter so much. This graph nicely illustrates, that in comparison to classical 2D-cell-culture, OoC technology has a surface area that is a magnitude higher. This is not just due to the body area of the biochip itself, but also due to the tubing needed for perfusion and the reservoirs. So, if you are testing novel compounds in your organ model, pay close attention to the adsorption rates of the materials used. Watch this short sequence from our webinar to learn more and understand which materials are best for compound testing: https://lnkd.in/epXZAkgg
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We’ve recently published a guest blog by Viraj Mehta on his proposed organ on chip classification system. Here's a breakdown of the four primary types of organ-on-chip technologies mentioned, based on their unique designs and functionalities: 1. Membrane-Based 2. Capillary Pinning or Micro-Compartmentalization 3. Sacrificial or Non-Sacrificial Materials-Based 4. Milli-Compartments (Milli-Wells) or Micro-Compartments (Micro-Wells) Based Understanding these categories helps in the effective application and standardization of organ-on-chip technologies, driving innovation and industrial adoption in drug discovery and disease modeling.
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Integrated multiorgan-on-chip model combining a gut- and liver-on-chip platform. Researchers from the Systems Ecology group, Alexander Mosig lab and Elisabeth Letellier lab have developed a multiorgan model combining the HuMiX gut-on-chip and Dynamic42 liver-on-chip to mimic the gut-liver axis. Additionally, to mimicking the bidirectional interconnection between the gut and the liver, their gut model also contains a human microbiome, known to influence drug responses and potential toxicity. In a proof-of-concept study, the model was initially tested with the colorectal cancer drug irinotecan. You can find the complete study here: https://lnkd.in/epkK_g_s Additionally, their work is featured with a beautiful frontispiece designed by Valentina Galata, which stunningly captured the essence of the multiorgan model. #microbiome #drugdevelopment #organonchip #3R #preclinical Universitätsklinikum Jena, Luxembourg Centre for Systems Biomedicine (LCSB) - University of Luxembourg
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We are curious. Organ-on-chip models replicate human biology extremely well and are therefore suitable for a wealth of applications in pharma and biomedical research. We would like to hear from you what you are using organ models for, or if you're not using them yet, what you would like to use them for in the future.
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The RUBIN alliance "ATHANA" (Antifungal Therapy Approaches with Nanoparticle-Based Targeting of Drugs) just held its first strategy workshop, marking one year since the project kicked off last summer. Hosted at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, the meeting was attended by key alliance members and Projektträger Jülich, Forschungszentrum Jülich GmbH. It was inspiring to see the progress we've made - hitting milestones on time and fostering a vibrant exchange of ideas among partners. We were also excited to see the redesign of the ATHANA homepage, enhancing transparency and communication. A big thank you to all our partners - SmartDyeLivery GmbH, Dyomics Shop, BioControl Jena GmbH, Jena Bioscience GmbH, Universitätsklinikum Jena, HAPILA GmbH - and the Thüringer ClusterManagement, represented by Dr. Britta Wlotzka, for their continued support!
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[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Guest article by Viraj Mehta - Organ on chip classification system (OoCCS): Benefits and limitations The growth of microphysiological systems (MPS), especially organ-on-chips, has been significant over the past decade. However, widespread industrial adoption is hindered by a lack of regulatory guidelines and standardization. The proposed classification system aims to address these issues by categorizing organ-on-chips based on design and functionality, thus facilitating clearer regulatory guidelines, fostering innovation, and improving educational resources. You can read it here: https://zurl.co/wtTh
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Dynamic42 GmbH hat dies direkt geteilt
Erster ATHANA Strategieworkshop Nach einem Jahr seit Projektbeginn fand diese Woche der erste Strategieworkshop des ATHANA Konsortiums in den Räumlichkeiten des Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut Jena statt. Unter Anwesenheit des Projektträger Jülich (PtJ) präsentierten die acht Bündnispartner ihren Stand der Forschung und Entwicklungsarbeit und diskutierten den weiteren Verlauf der geplanten Arbeitsschritte. Laut Meilensteinplanung liegt das Projekt aktuell genau im Zeitplan und motiviert uns für die weitere Zusammenarbeit mit Dyomics, Dynamic42 GmbH, BioControl Jena GmbH, Jena Bioscience GmbH, Universitätsklinikum Jena, HAPILA GmbH und dem Thüringer ClusterManagement. Weitere Infos unter www.athana.net
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[Guest article] Organ-on-chip technology transforms infectious disease modelling Our most recent guest article, published in SelectScience, talks about how organ-on-chip technology can improve the understanding of host-pathogen interactions and the evaluation of antimicrobial treatments. You can find the article here: https://zurl.co/JEmT
A possible game-changer: infectious disease modelling with organ-on-chip technology
selectscience.net