WNK1

WNK1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4PWN
Dynodwyr
Cyfenwau	WNK1, HSAN2, HSN2, KDP, PPP1R167, PRKPSK, p65, WNK lysine deficient protein kinase 1
Dynodwyr allanol	OMIM: 605232 HomoloGene: 14253 GeneCards: WNK1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein serine/threonine kinase inhibitor activity; • transferase activity; • nucleotide binding; • potassium channel inhibitor activity; • phosphatase binding; • protein kinase inhibitor activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • chloride channel inhibitor activity; • magnesium ion binding; • protein serine/threonine kinase activity; • ATP binding; • protein kinase activity; • protein kinase binding; • protein kinase activator activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen;
Prosesau biolegol	• phosphorylation; • negative regulation of phosphatase activity; • neuron development; • positive regulation of systemic arterial blood pressure; • protein autophosphorylation; • negative regulation of protein serine/threonine kinase activity; • peptidyl-threonine phosphorylation; • negative regulation of pancreatic juice secretion; • negative regulation of kinase activity; • GO:0046999 regulation of cellular process; • cludo ïon; • GO:0007243 intracellular signal transduction; • negative regulation of protein kinase activity; • regulation of sodium ion transport; • protein phosphorylation; • negative regulation of sodium ion transport; • activation of protein kinase activity; • cellular response to calcium ion; • positive regulation of canonical Wnt signaling pathway; • positive regulation of T cell chemotaxis; • GO:0035404 peptidyl-serine phosphorylation; • positive regulation of ion transmembrane transporter activity; • negative regulation of cell-cell adhesion mediated by integrin; • negative regulation of heterotypic cell-cell adhesion; • GO:0034259 negative regulation of GTPase activity; • chemokine (C-C motif) ligand 21 signaling pathway; • homeostasis yr ïon; • T cell receptor signaling pathway; • lymphocyte migration into lymph node; • negative regulation of leukocyte cell-cell adhesion; • positive regulation of potassium ion import across plasma membrane; • cellular response to chemokine; • positive regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologau
	65125
	n/a
	ENSG00000060237
	n/a
	Q9H4A3
	n/a
	NM_001184985; NM_014823; NM_018979; NM_213655
	n/a
	NP_001171914; NP_055638; NP_061852; NP_998820
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WNK1 yw WNK1 a elwir hefyd yn Serine/threonine-protein kinase WNK1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12p13.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WNK1.

KDP
PSK
p65
HSN2
HSAN2
PRKWNK1
PPP1R167

Llyfryddiaeth

"Common variation in with no-lysine kinase 1 (WNK1) and blood pressure responses to dietary sodium or potassium interventions- family-based association study. ". Circ J. 2013. PMID 23059770.
"Novel missense mutations of WNK1 in patients with hypokalemic salt-losing tubulopathies. ". Clin Genet. 2013. PMID 22934535.
"Exome sequencing identifies a novel gene, WNK1, for susceptibility to pelvic organ prolapse (POP). ". PLoS One. 2015. PMID 25739019.
"Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing. ". Am J Physiol Renal Physiol. 2015. PMID 25477473.
"Lack of family-based association between common variations in WNK1 and blood pressure level.". Med Sci Monit. 2014. PMID 25321950.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] WNK1 - Cronfa NCBI

[1]

[2]