TPX2

TPX2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OL5, 3E5A, 3HA6, 4C3P
Dynodwyr
Cyfenwau	TPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, microtubule nucleation factor, TPX2 microtubule nucleation factor
Dynodwyr allanol	OMIM: 605917 HomoloGene: 8107 GeneCards: TPX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GTP binding • importin-alpha family protein binding • ATP binding • GO:0001948, GO:0016582 protein binding • protein kinase binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • spindle pole • microtubule • microtubule cytoskeleton • axon hillock • Cytosgerbwd • spindle • cytosol • nucleoplasm • mitotic spindle • microtubule organizing center • intercellular bridge Prosesau biolegol • regulation of mitotic spindle organization • cell cycle • Cellraniad • GO:0097285 apoptotic process • mitotic spindle assembly • cell population proliferation • activation of protein kinase activity • regulation of signal transduction by p53 class mediator • GO:0007067 Mitosis • regulation of G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	22974	n/a
Ensembl	ENSG00000088325	n/a
UniProt	Q9ULW0	n/a
RefSeq (mRNA)	NM_012112	n/a
RefSeq (protein)	NP_036244	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TPX2 yw TPX2 a elwir hefyd yn TPX2, microtubule nucleation factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TPX2.

• DIL2
• p100
• DIL-2
• HCTP4
• FLS353
• HCA519
• REPP86
• C20orf1
• C20orf2
• GD:C20orf1

Llyfryddiaeth

• "Therapeutic potential of targeting protein for Xklp2 silencing for pancreatic cancer. ". Cancer Med. 2015. PMID 25914189.
• "TPX2 impacts acetylation of histone H4 at lysine 16: implications for DNA damage response. ". PLoS One. 2014. PMID 25365214.
• "TPX2 expression is associated with poor survival in gastric cancer. ". World J Surg Oncol. 2017. PMID 28069036.
• "Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer. ". Cancer Biol Ther. 2016. PMID 27314162.
• "TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.". J Cell Biol. 2015. PMID 26240182.