TP53

TP53
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4X34, 4ZZJ, 5AOL, 5ABA, 5AOK, 2MWY, 5A7B, 5AOJ, 5AOI, 5ECG, 5AB9, 4FZ3, 4RP6, 4XR8, 5AOM, 4RP7, 5HOU, 5HP0, 5HPD, 5LGY, 5G4M, 5G4O, 5G4N, 5BUA
Dynodwyr
Cyfenwau	TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
Dynodwyr allanol	OMIM: 191170 HomoloGene: 460 GeneCards: TP53
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein N-terminus binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • protein self-association; • core promoter sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • protein phosphatase binding; • ATP binding; • transcription factor binding; • metal ion binding; • protein phosphatase 2A binding; • enzyme binding; • zinc ion binding; • chromatin binding; • protease binding; • damaged DNA binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase binding; • copper ion binding; • protein kinase binding; • chaperone binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • receptor tyrosine kinase binding; • p53 binding; • identical protein binding; • protein heterodimerization activity; • ubiquitin protein ligase binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • DNA binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • TFIID-class transcription factor complex binding; • mRNA 3'-UTR binding; • histone deacetylase binding; • disordered domain specific binding; • promoter-specific chromatin binding; • histone deacetylase regulator activity; • protein homodimerization activity; • MDM2/MDM4 family protein binding;
Cydrannau o'r gell	• cytoplasm; • mitocondria; • cnewyllyn cell; • nuclear body; • transcription factor TFIID complex; • nuclear matrix; • replication fork; • nucleolus; • Reticwlwm endoplasmig; • nucleoplasm; • mitochondrial matrix; • PML body; • cytosol; • intracellular anatomical structure; • transcription regulator complex; • GO:0009327 protein-containing complex; • site of double-strand break;
Prosesau biolegol	• positive regulation of histone deacetylation; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • proses rythmig; • replicative senescence; • negative regulation of telomerase activity; • oligodendrocyte apoptotic process; • cellular response to DNA damage stimulus; • intrinsic apoptotic signaling pathway; • positive regulation of neuron apoptotic process; • regulation of mitochondrial membrane permeability; • positive regulation of reactive oxygen species metabolic process; • cellular response to ionizing radiation; • positive regulation of thymocyte apoptotic process; • negative regulation of helicase activity; • cell cycle; • Ras protein signal transduction; • cell population proliferation; • cellular response to hypoxia; • negative regulation of cell population proliferation; • nucleotide-excision repair; • cellular response to glucose starvation; • GO:0009373 regulation of transcription, DNA-templated; • GO:1904576 response to antibiotic; • transcription, DNA-templated; • ER overload response; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of cell growth; • intrinsic apoptotic signaling pathway by p53 class mediator; • positive regulation of peptidyl-tyrosine phosphorylation; • GO:0022415 viral process; • response to gamma radiation; • negative regulation of fibroblast proliferation; • positive regulation of intrinsic apoptotic signaling pathway; • cell differentiation; • determination of adult lifespan; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • cellular response to UV; • DNA damage response, signal transduction by p53 class mediator; • negative regulation of apoptotic process; • protein tetramerization; • oxidative stress-induced premature senescence; • positive regulation of release of cytochrome c from mitochondria; • circadian behavior; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0034613 protein localization; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • positive regulation of execution phase of apoptosis; • multicellular organism development; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • GO:1901313 positive regulation of gene expression; • mitotic G1 DNA damage checkpoint signaling; • positive regulation of protein oligomerization; • positive regulation of apoptotic process; • entrainment of circadian clock by photoperiod; • response to X-ray; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • base-excision repair; • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; • regulation of cell cycle G2/M phase transition; • proteasome-mediated ubiquitin-dependent protein catabolic process; • regulation of signal transduction by p53 class mediator; • GO:0097285 apoptotic process; • transcription by RNA polymerase II; • positive regulation of protein export from nucleus; • GO:0010703, GO:0010702 programmed cell death; • regulation of apoptotic process; • protein deubiquitination; • phosphatidylinositol-mediated signaling; • GO:1901227 negative regulation of transcription by RNA polymerase II; • autophagy; • mRNA transcription; • cytokine-mediated signaling pathway; • positive regulation of RNA polymerase II transcription preinitiation complex assembly; • RNA polymerase II preinitiation complex assembly; • protein homotetramerization; • GO:0034622 protein-containing complex assembly; • cellular response to gamma radiation; • signal transduction by p53 class mediator; • cellular response to actinomycin D; • positive regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • in utero embryonic development; • somitogenesis; • release of cytochrome c from mitochondria; • hematopoietic progenitor cell differentiation; • T cell proliferation involved in immune response; • B cell lineage commitment; • T cell lineage commitment; • response to ischemia; • double-strand break repair; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • protein import into nucleus; • GO:0001306 response to oxidative stress; • transforming growth factor beta receptor signaling pathway; • gastrulation; • negative regulation of neuroblast proliferation; • central nervous system development; • heart development; • Rhythm circadaidd; • negative regulation of DNA replication; • rRNA transcription; • response to UV; • response to salt stress; • embryo development ending in birth or egg hatching; • negative regulation of gene expression; • positive regulation of cardiac muscle cell apoptotic process; • cerebellum development; • negative regulation of transforming growth factor beta receptor signaling pathway; • T cell differentiation in thymus; • regulation of tissue remodeling; • multicellular organism growth; • positive regulation of mitochondrial membrane permeability; • positive regulation of transcription from RNA polymerase II promoter in response to stress; • regulation of cell population proliferation; • mitochondrial DNA repair; • regulation of DNA damage response, signal transduction by p53 class mediator; • regulation of neuron apoptotic process; • negative regulation of proteolysis; • negative regulation of mitotic cell cycle; • bone marrow development; • embryonic organ development; • protein stabilization; • GO:0051312, GO:0007083 chromosome organization; • neuron apoptotic process; • regulation of cell cycle; • hematopoietic stem cell differentiation; • interferon-gamma-mediated signaling pathway; • cardiac septum morphogenesis; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of programmed necrotic cell death; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • regulation of thymocyte apoptotic process; • GO:0060554, GO:0060555 necroptosis; • cellular response to UV-C; • negative regulation of mitophagy; • regulation of mitochondrial membrane permeability involved in apoptotic process; • regulation of intrinsic apoptotic signaling pathway by p53 class mediator; • negative regulation of production of miRNAs involved in gene silencing by miRNA; • negative regulation of glucose catabolic process to lactate via pyruvate; • intrinsic apoptotic signaling pathway in response to hypoxia; • regulation of fibroblast apoptotic process; • negative regulation of reactive oxygen species metabolic process; • regulation of cellular senescence;
	Sources:Amigo / QuickGO
Orthologau
	7157
	n/a
	ENSG00000141510
	n/a
	P04637
	n/a
NM_001276761; NM_000546; NM_001126112; NM_001126113; NM_001126114;
	NM_001126115; NM_001126116; NM_001126117; NM_001126118; NM_001276695; NM_001276696; NM_001276697; NM_001276698; NM_001276699; NM_001276760
	n/a
NP_000537; NP_001119584; NP_001119585; NP_001119586; NP_001119587;
	NP_001119588; NP_001119589; NP_001119590; NP_001263624; NP_001263625; NP_001263626; NP_001263627; NP_001263628; NP_001263689; NP_001263690
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP53 yw TP53 a elwir hefyd yn Tumor protein p53 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP53.

P53
BCC7
LFS1
TRP53

Llyfryddiaeth

"Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. ". PLoS One. 2017. PMID 29211796.
"TP53Mutation Status of Tubo-ovarian and Peritoneal High-grade Serous Carcinoma with a Wild-type p53 Immunostaining Pattern. ". Anticancer Res. 2017. PMID 29187446.
"Expression of p53 protein in high-grade gastroenteropancreatic neuroendocrine carcinoma. ". PLoS One. 2017. PMID 29112960.
"Partially Purified Gloriosa superba Peptides Inhibit Colon Cancer Cell Viability by Inducing Apoptosis Through p53 Upregulation. ". Am J Med Sci. 2017. PMID 29078848.
"Identification of Clinical and Biologic Correlates Associated With Outcome in Children With Adrenocortical Tumors Without Germline TP53 Mutations: A St Jude Adrenocortical Tumor Registry and Children's Oncology Group Study.". J Clin Oncol. 2017. PMID 29058986.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] TP53 - Cronfa NCBI

[1]

[2]