TIMP1

TIMP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1D2B, 1OO9, 1UEA, 2J0T, 3MA2, 3V96
Dynodwyr
Cyfenwau	TIMP1, CLGI, EPA, EPO, HCI, TIMP, TIMP-1, TIMP metallopeptidase inhibitor 1
Dynodwyr allanol	OMIM: 305370 HomoloGene: 36321 GeneCards: TIMP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • GO:0048551 enzyme inhibitor activity • cytokine activity • metal ion binding • protease binding • GO:0001948, GO:0016582 protein binding • metalloendopeptidase inhibitor activity • growth factor activity • zinc ion binding Cydrannau o'r gell • GO:0005578 extracellular matrix • extracellular region • basement membrane • extracellular exosome • platelet alpha granule lumen • extracellular space • endoplasmic reticulum lumen • collagen Prosesau biolegol • response to cytokine • negative regulation of peptidase activity • GO:0010260 heneiddio • response to peptide hormone • platelet degranulation • wound healing • negative regulation of apoptotic process • extracellular matrix disassembly • negative regulation of trophoblast cell migration • response to organic substance • cell activation • cartilage development • regulation of integrin-mediated signaling pathway • positive regulation of cell population proliferation • response to hormone • negative regulation of membrane protein ectodomain proteolysis • negative regulation of endopeptidase activity • GO:0048553 negative regulation of catalytic activity • negative regulation of metallopeptidase activity • post-translational protein modification • regulation of signaling receptor activity • connective tissue replacement involved in inflammatory response wound healing • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7076	n/a
Ensembl	ENSG00000102265	n/a
UniProt	P01033 Q6FGX5	n/a
RefSeq (mRNA)	NM_003254	n/a
RefSeq (protein)	NP_003245 NP_003245.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TIMP1 yw TIMP1 a elwir hefyd yn TIMP metallopeptidase inhibitor 1, isoform CRA_a a TIMP metallopeptidase inhibitor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TIMP1.

• EPA
• EPO
• HCI
• CLGI
• TIMP
• TIMP-1

Llyfryddiaeth

• "Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer. ". Mol Cancer. 2016. PMID 27130446.
• "Aldosterone Induces Tissue Inhibitor of Metalloproteinases-1 Expression and Further Contributes to Collagen Accumulation: From Clinical to Bench Studies. ". Hypertension. 2016. PMID 27113051.
• "Tissue inhibitor of metalloproteinases 1, a novel biomarker of tuberculosis. ". Mol Med Rep. 2017. PMID 27959391.
• "TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway. ". J Exp Clin Cancer Res. 2016. PMID 27644693.
• "Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients.". J Neurooncol. 2016. PMID 27619981.