SPEN

SPEN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OW1, 2RT5, 4P6Q
Dynodwyr
Cyfenwau	SPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor, RATARS
Dynodwyr allanol	OMIM: 613484 HomoloGene: 124461 GeneCards: SPEN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA binding • GO:0001106 transcription corepressor activity Cydrannau o'r gell • transcription repressor complex • extracellular exosome • cnewyllyn cell • nucleoplasm Prosesau biolegol • Notch signaling pathway • positive regulation of neurogenesis • mRNA splicing, via spliceosome • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23013	n/a
Ensembl	ENSG00000065526	n/a
UniProt	Q96T58	n/a
RefSeq (mRNA)	NM_015001	n/a
RefSeq (protein)	NP_055816	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SPEN yw SPEN a elwir hefyd yn Msx2-interacting protein a Spen family transcriptional repressor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.21-p36.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SPEN.

• MINT
• SHARP
• RBM15C
• HIAA0929

Llyfryddiaeth

• "Identification of a quantitative MINT locus methylation profile predicting local regional recurrence of rectal cancer. ". Clin Cancer Res. 2010. PMID 20460484.
• "[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons]. ". Antibiotiki. 1976. PMID 1020939.
• "The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers. ". Cancer Res. 2015. PMID 26297734.
• "The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs. ". Nucleic Acids Res. 2014. PMID 24748666.
• "RNA steady-state defects in myotonic dystrophy are linked to nuclear exclusion of SHARP.". EMBO Rep. 2011. PMID 21637295.