SORBS3

SORBS3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CT3, 2DLM, 2NWM, 2YUP
Dynodwyr
Cyfenwau	SORBS3, SCAM-1, SCAM1, SH3D4, sorbin and SH3 domain containing 3
Dynodwyr allanol	OMIM: 610795 HomoloGene: 4218 GeneCards: SORBS3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • vinculin binding • transcription factor binding • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • cell junction • Cytosgerbwd • cnewyllyn cell • focal adhesion Prosesau biolegol • cell-substrate adhesion • cell adhesion • muscle contraction • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of stress fiber assembly • positive regulation of cytoskeleton organization • positive regulation of MAPK cascade • actin filament organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10174	n/a
Ensembl	ENSG00000120896	n/a
UniProt	O60504	n/a
RefSeq (mRNA)	NM_001018003 NM_005775	n/a
RefSeq (protein)	NP_001018003 NP_005766	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SORBS3 yw SORBS3 a elwir hefyd yn Sorbin and SH3 domain containing 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SORBS3.

• SCAM1
• SH3D4
• SCAM-1

Llyfryddiaeth

• "Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation. ". J Virol. 2015. PMID 25972535.
• "Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. ". Exp Cell Res. 2010. PMID 20361963.
• "Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes. ". Clin Epigenetics. 2016. PMID 27437034.
• "Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth. ". Oncogene. 2007. PMID 17486060.
• "Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities.". J Biol Chem. 1999. PMID 10585480.