RPA2

RPA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DPU, 1L1O, 1QUQ, 1Z1D, 2PI2, 2PQA, 2Z6K, 3KDF, 4MQV, 4OU0
Dynodwyr
Cyfenwau	RPA2, REPA2, RP-A p32, RP-A p34, RPA32, replication protein A2
Dynodwyr allanol	OMIM: 179836 HomoloGene: 37712 GeneCards: RPA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • protein N-terminus binding • single-stranded DNA binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • enzyme binding • protein phosphatase binding • ubiquitin protein ligase binding • G-rich strand telomeric DNA binding • double-stranded DNA binding • sequence-specific DNA binding Cydrannau o'r gell • site of double-strand break • PML body • nucleoplasm • telomere • DNA replication factor A complex • chromatin • cnewyllyn cell • nuclear body • condensed nuclear chromosome Prosesau biolegol • nucleotide-excision repair, DNA gap filling • DNA recombination • interstrand cross-link repair • regulation of double-strand break repair via homologous recombination • error-free translesion synthesis • G1 phase • error-prone translesion synthesis • cellular response to DNA damage stimulus • DNA replication • mitotic G1 DNA damage checkpoint signaling • regulation of DNA damage checkpoint • regulation of cellular response to heat • DNA mismatch repair • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • base-excision repair • nucleotide-excision repair • nucleotide-excision repair, preincision complex stabilization • regulation of signal transduction by p53 class mediator • GO:0100026 DNA repair • double-strand break repair via homologous recombination • nucleotide-excision repair, preincision complex assembly • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA incision, 3'-to lesion • protein localization to chromosome • telomere maintenance • telomere maintenance via semi-conservative replication • G1/S transition of mitotic cell cycle • telomere maintenance via recombination • DNA topological change • DNA unwinding involved in DNA replication • mitotic recombination • telomere maintenance via telomerase • reciprocal meiotic recombination • heteroduplex formation • positive regulation of helicase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6118	n/a
Ensembl	ENSG00000117748	n/a
UniProt	P15927	n/a
RefSeq (mRNA)	NM_001286076 NM_001297558 NM_002946 NM_001355128 NM_001355129	n/a
RefSeq (protein)	NP_001273005 NP_001284487 NP_002937 NP_001342057 NP_001342058	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RPA2 yw RPA2 a elwir hefyd yn Replication protein A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p35.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RPA2.

• REPA2
• RPA32
• RP-A*p32
• RP-A*p34

Llyfryddiaeth

• "Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis. ". Nucleic Acids Res. 2009. PMID 19671522.
• "Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. ". J Biol Chem. 2007. PMID 17928296.
• "Proteomic analysis of BRCA1-depleted cell line reveals a putative role for replication protein A2 up-regulation in BRCA1 breast tumor development. ". Proteomics Clin Appl. 2010. PMID 21137066.
• "Identification of proteins that may directly interact with human RPA. ". J Biochem. 2010. PMID 20679368.
• "The role of RPA2 phosphorylation in homologous recombination in response to replication arrest.". Carcinogenesis. 2010. PMID 20130019.