RARB

RARB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI
Dynodwyr
Cyfenwau	RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta
Dynodwyr allanol	OMIM: 180220 HomoloGene: 68100 GeneCards: RARB
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001948, GO:0016582 protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding; • retinoid X receptor binding; • GO:0000975 transcription cis-regulatory region binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity;
Cydrannau o'r gell	• cytoplasm; • nucleoplasm; • cnewyllyn cell; • RNA polymerase II transcription regulator complex;
Prosesau biolegol	• growth plate cartilage development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • neurogenesis; • ureteric bud development; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cartilage development; • multicellular organism growth; • embryonic eye morphogenesis; • positive regulation of programmed cell death; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • retinal pigment epithelium development; • transcription, DNA-templated; • outflow tract septum morphogenesis; • negative regulation of chondrocyte differentiation; • retinoic acid receptor signaling pathway; • regulation of myelination; • retina development in camera-type eye; • positive regulation of neuron differentiation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • ventricular cardiac muscle cell differentiation; • transcription initiation from RNA polymerase II promoter; • bone development; • embryonic digestive tract development; • striatum development; • GO:0072468 signal transduction; • negative regulation of cell population proliferation; • glandular epithelial cell development; • steroid hormone mediated signaling pathway; • embryonic hindlimb morphogenesis; • liver development; • multicellular organism development; • hormone-mediated signaling pathway; • cell differentiation; • response to retinoic acid; • response to lipid; • gland development; • bone morphogenesis; • epithelium development; • cellular response to retinoic acid;
	Sources:Amigo / QuickGO
Orthologau
	5915
	n/a
	ENSG00000077092
	n/a
	P10826; Q5QHG3
	n/a
NM_000965; NM_001290216; NM_001290217; NM_001290266; NM_001290276;
	NM_001290277; NM_001290300; NM_016152
	n/a
NP_000956; NP_001277145; NP_001277146; NP_001277195; NP_001277205;
	NP_001277206; NP_001277229; NP_057236; NP_001277146.1; NP_001277205.1; NP_057236.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RARB yw RARB a elwir hefyd yn Retinoic acid receptor beta 5 a Retinoic acid receptor beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p24.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RARB.

HAP
RRB2
NR1B2
MCOPS12
RARbeta1

Llyfryddiaeth

"Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation. ". Phytother Res. 2015. PMID 25981383.
"Association of methylation of the RAR-β gene with cigarette smoking in non-small cell lung cancer with Southern-Central Chinese population. ". Asian Pac J Cancer Prev. 2014. PMID 25605205.
"Gain-of-Function Mutations in RARB Cause Intellectual Disability with Progressive Motor Impairment. ". Hum Mutat. 2016. PMID 27120018.
"Promoter Methylation of the Retinoic Acid Receptor Beta2 (RARβ2) Is Associated with Increased Risk of Breast Cancer: A PRISMA Compliant Meta-Analysis. ". PLoS One. 2015. PMID 26451736.
"Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation.". Proc Natl Acad Sci U S A. 2015. PMID 26080448.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RARB - Cronfa NCBI

[1]

[2]