RAP2A

RAP2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KAO, 2RAP, 3RAP
Dynodwyr
Cyfenwau	RAP2A, K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family
Dynodwyr allanol	OMIM: 179540 HomoloGene: 10875 GeneCards: RAP2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0001948, GO:0016582 protein binding • magnesium ion binding • GO:0006184 GTPase activity • GTP binding • GDP binding Cydrannau o'r gell • recycling endosome • cytosol • endosome • bilen • Cellbilen • recycling endosome membrane • midbody Prosesau biolegol • actin cytoskeleton reorganization • microvillus assembly • positive regulation of protein phosphorylation • establishment of protein localization • Rap protein signal transduction • regulation of dendrite morphogenesis • regulation of JNK cascade • negative regulation of cell migration • establishment of epithelial cell apical/basal polarity • positive regulation of protein autophosphorylation • protein localization to plasma membrane • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5911	n/a
Ensembl	ENSG00000125249	n/a
UniProt	P10114	n/a
RefSeq (mRNA)	NM_021033	n/a
RefSeq (protein)	NP_066361	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAP2A yw RAP2A a elwir hefyd yn RAP2A, member of RAS oncogene family (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAP2A.

• KREV
• RAP2
• K-REV
• RbBP-30

Llyfryddiaeth

• "Rap2 regulates androgen sensitivity in human prostate cancer cells. ". Prostate. 2007. PMID 17918750.
• "Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1. ". Oncol Rep. 2017. PMID 28405688.
• "Role of Rap2 and its Downstream Effectors in Tumorigenesis. ". Anticancer Agents Med Chem. 2015. PMID 25980814.
• "[Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells]. ". Zhongguo Fei Ai Za Zhi. 2014. PMID 25248704.
• "Constitutively active Rap2 transgenic mice display fewer dendritic spines, reduced extracellular signal-regulated kinase signaling, enhanced long-term depression, and impaired spatial learning and fear extinction.". J Neurosci. 2008. PMID 18701680.