RAN

RAN
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1I2M, 1IBR, 1K5D, 1K5G, 1QBK, 1RRP, 2MMC, 2MMG, 3CH5, 3EA5, 3GJ0, 3GJ3, 3GJ4, 3GJ5, 3GJ6, 3GJ7, 3GJ8, 3GJX, 3NBY, 3NBZ, 3NC0, 3NC1, 3ZJY, 4C0Q, 4GMX, 4GPT, 4HAT, 4HAU, 4HAV, 4HAW, 4HAX, 4HAY, 4HAZ, 4HB0, 4HB2, 4HB3, 4HB4, 4OL0, 4WVF, 5CIQ, 5CIT, 5CIW, 5CJ2, 5CLL, 5CLQ, 5DH9, 5DHA, 5DHF, 5DI9, 5DIF, 3A6P, 1A2K, 5DIS, 5BXQ, 5DLQ, 5FYQ, 2N1B, 5JLJ
Dynodwyr
Cyfenwau	RAN, ARA24, Gsp1, TC4, Ran, member RAS oncogene family
Dynodwyr allanol	OMIM: 601179 HomoloGene: 68143 GeneCards: RAN
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • GO:0001105 transcription coactivator activity; • pre-miRNA binding; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • androgen receptor binding; • GO:0006184 GTPase activity; • GTP binding; • RNA binding; • cadherin binding; • magnesium ion binding; • GO:0005487 structural constituent of nuclear pore; • GDP binding; • protein heterodimerization activity; • nuclear export signal receptor activity; • metal ion binding; • protein domain specific binding; • GO:0032403 protein-containing complex binding; • dynein intermediate chain binding; • importin-alpha family protein binding;
Cydrannau o'r gell	• recycling endosome; • cytosol; • Flemming body; • melanosome; • nucleoplasm; • midbody; • RNA nuclear export complex; • nucleolus; • centriole; • chromatin; • extracellular exosome; • bilen; • cytoplasm; • cnewyllyn cell; • GO:0005578 extracellular matrix; • nuclear pore; • host cell; • nuclear envelope; • GO:0009327 protein-containing complex; • male germ cell nucleus; • manchette; • sperm flagellum;
Prosesau biolegol	• ribosomal small subunit export from nucleus; • GO:0046795 intracellular transport of virus; • androgen receptor signaling pathway; • protein localization to nucleolus; • GO:0043148 mitotic spindle organization; • DNA metabolic process; • pre-miRNA export from nucleus; • Cellraniad; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • nucleocytoplasmic transport; • protein export from nucleus; • protein transport; • ribosomal large subunit export from nucleus; • cell cycle; • positive regulation of protein binding; • GO:0022415 viral process; • tRNA export from nucleus; • GO:0007067 Mitosis; • protein import into nucleus; • GO:0061715 miRNA metabolic process; • regulation of cholesterol biosynthetic process; • GO:1905616 regulation of gene silencing by miRNA; • GO:0015915 transport; • mitotic sister chromatid segregation; • GTP metabolic process; • snRNA import into nucleus; • positive regulation of protein import into nucleus; • spermatid development; • GO:1904578 response to organic cyclic compound; • hippocampus development; • actin cytoskeleton organization; • regulation of protein binding; • cellular response to mineralocorticoid stimulus;
	Sources:Amigo / QuickGO
Orthologau
	5901
	n/a
	ENSG00000132341
	n/a
	P62826
	n/a
	NM_006325; NM_001300796; NM_001300797
	n/a
	NP_001287725; NP_001287726; NP_006316
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn RAN yw RAN a elwir hefyd yn GTP-binding nuclear protein Ran a RAN, member RAS oncogene family (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn RAN.

TC4
Gsp1
ARA24

Llyfryddiaeth

"Ran signaling in melanoma: implications for the development of alternative therapeutic strategies. ". Cancer Lett. 2015. PMID 25444926.
"Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase. ". Proc Natl Acad Sci U S A. 2014. PMID 25331866.
"Repeat-associated non-AUG translation from antisense CCG repeats in fragile X tremor/ataxia syndrome. ". Ann Neurol. 2016. PMID 27761921.
"The GTPase RAN regulates multiple steps of the centrosome life cycle. ". Chromosome Res. 2016. PMID 26725228.
"Inter-cellular transport of ran GTPase.". PLoS One. 2015. PMID 25894517.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] RAN - Cronfa NCBI

[1]

[2]