PPARD Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GWX , 1Y0S , 2AWH , 2B50 , 2BAW , 2ENV , 2GWX , 2J14 , 2Q5G , 2XYJ , 2XYW , 2XYX , 2ZNP , 2ZNQ , 3D5F , 3DY6 , 3ET2 , 3GWX , 3GZ9 , 3OZ0 , 3PEQ , 3SP9 , 3TKM
Dynodwyr Cyfenwau PPARD Dynodwyr allanol OMIM: 600409 HomoloGene: 4544 GeneCards: PPARD Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • fatty acid binding • GO:0001948, GO:0016582 protein binding • linoleic acid binding • protein heterodimerization activity • lipid binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • NF-kappaB binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • nuclear receptor coactivator activity • signaling receptor activity Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • RNA polymerase II transcription regulator complex Prosesau biolegol • fatty acid catabolic process • positive regulation of myoblast proliferation • positive regulation of epidermis development • cell differentiation • negative regulation of smooth muscle cell proliferation • negative regulation of myoblast differentiation • GO:0009373 regulation of transcription, DNA-templated • placenta development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of smooth muscle cell migration • wound healing • mRNA transcription • cholesterol metabolic process • negative regulation of apoptotic process • response to glucose • response to activity • response to organic substance • generation of precursor metabolites and energy • regulation of fat cell differentiation • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • response to vitamin A • heart development • cell-substrate adhesion • keratinocyte proliferation • GO:1901313 positive regulation of gene expression • proteoglycan metabolic process • regulation of cell population proliferation • negative regulation of cell growth • fatty acid oxidation • positive regulation of cell population proliferation • glucose metabolic process • phospholipid biosynthetic process • negative regulation of epithelial cell proliferation • positive regulation of skeletal muscle tissue regeneration • apoptotic signaling pathway • vitamin A metabolic process • positive regulation of phosphatidylinositol 3-kinase signaling • keratinocyte migration • adipose tissue development • transcription initiation from RNA polymerase II promoter • regulation of skeletal muscle satellite cell proliferation • positive regulation of fat cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of inflammatory response • cellular response to lipopolysaccharide • cellular response to hypoxia • negative regulation of collagen biosynthetic process • positive regulation of insulin secretion • steroid hormone mediated signaling pathway • GO:0097285 apoptotic process • cell population proliferation • GO:1901227 negative regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • axon ensheathment • decidualization • fatty acid transport • embryo implantation • negative regulation of pri-miRNA transcription by RNA polymerase II • lipid metabolism • fatty acid beta-oxidation • glucose transmembrane transport • fatty acid metabolic process • multicellular organism development • hormone-mediated signaling pathway • negative regulation of cholesterol storage • regulation of lipid metabolic process • response to lipid • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARD yw PPARD a elwir hefyd yn Peroxisome proliferator activated receptor delta (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.31.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPARD.
FAAR
NUC1
NUCI
NR1C2
NUCII
PPARB
"Circulating "LncPPARδ" From Monocytes as a Novel Biomarker for Coronary Artery Diseases. ". Medicine (Baltimore) . 2016. PMID 26871769 . "Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. ". Eur J Pharmacol . 2016. PMID 26852954 . "Association of peroxisome proliferator-activated receptor delta and additional gene-smoking interaction on cardiovascular disease. ". Clin Exp Hypertens . 2017. PMID 28287878 . "PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions. ". Leukemia . 2017. PMID 28050012 . "PPARD rs2016520 polymorphism is associated with metabolic traits in a large population of Chinese adults. ". Gene . 2016. PMID 26915488 . 
