PLAT

PLAT
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A5H, 1BDA, 1PK2, 1PML, 1RTF, 1TPG, 1TPK, 1TPM, 1TPN, 5BRR
Dynodwyr
Cyfenwau	PLAT, T-PA, TPA, plasminogen activator, tissue type
Dynodwyr allanol	OMIM: 173370 HomoloGene: 717 GeneCards: PLAT
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • phosphoprotein binding • serine-type peptidase activity • serine-type endopeptidase activity • signaling receptor binding • hydrolase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • GO:0005578 extracellular matrix • apical part of cell • secretory granule • extracellular region • cell surface • extracellular exosome • extracellular space • collagen-containing extracellular matrix • Schaffer collateral - CA1 synapse • glutamatergic synapse Prosesau biolegol • negative regulation of proteolysis • response to hypoxia • fibrinolysis • blood coagulation • smooth muscle cell migration • proteolysis • platelet-derived growth factor receptor signaling pathway • plasminogen activation • trans-synaptic signaling by BDNF, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5327	n/a
Ensembl	ENSG00000104368	n/a
UniProt	P00750	n/a
RefSeq (mRNA)	NM_033011 NM_000930 NM_000931 NM_001319189	n/a
RefSeq (protein)	NP_000921 NP_001306118 NP_127509	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLAT yw PLAT a elwir hefyd yn Plasminogen activator, tissue type (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLAT.

• TPA
• T-PA

Llyfryddiaeth

• "Endurance exercise per se reduces the cardiovascular risk marker t-PA antigen in healthy, younger, overweight men. ". Thromb Res. 2017. PMID 28254694.
• "Induction of Amnion Epithelial Apoptosis by Cortisol via tPA/Plasmin System. ". Endocrinology. 2016. PMID 27690691.
• "A lethal phenotype associated with tissue plasminogen deficiency in humans. ". Hum Genet. 2016. PMID 27417437.
• "Plasma tPA-Activity and Progression of Cerebral White Matter Hyperintensities in Lacunar Stroke Patients. ". PLoS One. 2016. PMID 26942412.
• "Interferons Induce STAT1-Dependent Expression of Tissue Plasminogen Activator, a Pathogenicity Factor in Puumala Hantavirus Disease.". J Infect Dis. 2016. PMID 26704613.