PEX14

PEX14
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2W84, 2W85, 4BXU
Dynodwyr
Cyfenwau	PEX14, NAPP2, PBD13A, Pex14p, dJ734G22.2, peroxisomal biogenesis factor 14
Dynodwyr allanol	OMIM: 601791 HomoloGene: 37936 GeneCards: PEX14
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001106 transcription corepressor activity • protein N-terminus binding • microtubule binding • GO:0001948, GO:0016582 protein binding • beta-tubulin binding • signaling receptor binding Cydrannau o'r gell • integral component of membrane • bilen • peroxisomal membrane • peroxisome • intracellular anatomical structure • cnewyllyn cell • fibrillar center • peroxisomal importomer complex • GO:0009327 protein-containing complex Prosesau biolegol • peroxisome organization • negative regulation of protein homotetramerization • peroxisome transport along microtubule • negative regulation of protein binding • negative regulation of DNA-binding transcription factor activity • microtubule anchoring • protein import into peroxisome matrix • protein import into peroxisome matrix, substrate release • protein transport • GO:0045996 negative regulation of transcription, DNA-templated • protein homooligomerization • protein import into peroxisome matrix, translocation • GO:0015915 transport • protein targeting to peroxisome • protein import into peroxisome matrix, docking • protein ubiquitination • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5195	n/a
Ensembl	ENSG00000142655	n/a
UniProt	O75381	n/a
RefSeq (mRNA)	NM_004565	n/a
RefSeq (protein)	NP_004556	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PEX14 yw PEX14 a elwir hefyd yn Peroxisomal biogenesis factor 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PEX14.

• NAPP2
• PBD13A
• Pex14p
• dJ734G22.2

Llyfryddiaeth

• "Identification of a new complementation group of the peroxisome biogenesis disorders and PEX14 as the mutated gene. ". Hum Mutat. 2004. PMID 15146459.
• "Mammalian Pex14p: membrane topology and characterisation of the Pex14p-Pex14p interaction. ". Biochim Biophys Acta. 2002. PMID 12488033.
• "First Japanese case of Zellweger syndrome with a mutation in PEX14. ". Pediatr Int. 2015. PMID 26627464.
• "Identification of a novel PEX14 mutation in Zellweger syndrome. ". J Med Genet. 2008. PMID 18285423.
• "A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.". J Biol Chem. 2014. PMID 24235149.