NTRK3

NTRK3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1WWC, 3V5Q, 4YMJ
Dynodwyr
Cyfenwau	NTRK3, GP145-TrkC, TRKC, gp145(trkC), neurotrophic receptor tyrosine kinase 3
Dynodwyr allanol	OMIM: 191316 HomoloGene: 49183 GeneCards: NTRK3
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • protein tyrosine kinase activity; • neurotrophin binding; • protein kinase activity; • transferase activity; • transmembrane receptor protein tyrosine kinase activity; • kinase activity; • neurotrophin receptor activity; • GPI-linked ephrin receptor activity; • ATP binding; • p53 binding; • GO:0001948, GO:0016582 protein binding; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • receptor complex; • integral component of plasma membrane; • Cellbilen; • glutamatergic synapse; • integral component of postsynaptic membrane; • axon;
Prosesau biolegol	• Rhythm circadaidd; • positive regulation of peptidyl-serine phosphorylation; • ephrin receptor signaling pathway; • response to ethanol; • activation of protein kinase B activity; • positive regulation of synapse assembly; • multicellular organism development; • positive regulation of actin cytoskeleton reorganization; • positive regulation of cell migration; • response to corticosterone; • protein autophosphorylation; • negative regulation of cell death; • heart development; • positive regulation of apoptotic process; • peptidyl-tyrosine phosphorylation; • cochlea development; • nervous system development; • GO:1901313 positive regulation of gene expression; • GO:0033128 negative regulation of protein phosphorylation; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • protein phosphorylation; • neurotrophin signaling pathway; • cellular response to retinoic acid; • neuron fate specification; • positive regulation of axon extension involved in regeneration; • positive regulation of cell population proliferation; • modulation by virus of host transcription; • lens fiber cell differentiation; • mechanoreceptor differentiation; • response to axon injury; • positive regulation of positive chemotaxis; • cell differentiation; • negative regulation of astrocyte differentiation; • positive regulation of protein phosphorylation; • neuron migration; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • regulation of postsynaptic density assembly; • regulation of presynapse assembly; • negative regulation of signal transduction; • positive regulation of neuron projection development; • neuronal action potential propagation; • myelination in peripheral nervous system; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • cellular response to nerve growth factor stimulus; • regulation of MAPK cascade; • positive regulation of MAPK cascade; • positive regulation of neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	4916
	n/a
	ENSG00000140538
	n/a
	Q16288
	n/a
NM_001007156; NM_001012338; NM_001243101; NM_002530; NM_001320134;
	NM_001320135; NM_001375810; NM_001375811; NM_001375812; NM_001375813; NM_001375814
	n/a
NP_001007157; NP_001012338; NP_001230030; NP_001307063; NP_001307064;
	NP_002521; NP_001362739; NP_001362740; NP_001362741; NP_001362742; NP_001362743; NP_002521.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NTRK3 yw NTRK3 a elwir hefyd yn Tyrosine-protein kinase receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q25.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NTRK3.

TRKC
GP145-TrkC
gp145(trkC)

Llyfryddiaeth

"Copy number variations of neurotrophic tyrosine receptor kinase 3 (NTRK3) may predict prognosis of ovarian cancer. ". Medicine (Baltimore). 2017. PMID 28746220.
"A novel microRNA located in the TrkCgene regulates the Wnt signaling pathway and is differentially expressed in colorectal cancer specimens. ". J Biol Chem. 2017. PMID 28100780.
"Targeted exome sequencing for the identification of a protective variant against Internet gaming disorder at rs2229910 of neurotrophic tyrosine kinase receptor, type 3 (NTRK3): A pilot study. ". J Behav Addict. 2016. PMID 27826991.
"Experimental verification of a conserved intronic microRNA located in the human TrkC gene with a cell type-dependent apoptotic function. ". Cell Mol Life Sci. 2015. PMID 25772499.
"NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.". PLoS Genet. 2013. PMID 23874207.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] NTRK3 - Cronfa NCBI

[1]

[2]