MME

MME
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9, 4CTH, 5JMY
Dynodwyr
Cyfenwau	MME, CALLA, CD10, NEP, SFE, membrane metallo-endopeptidase, membrane metalloendopeptidase, CMT2T, SCA43
Dynodwyr allanol	OMIM: 120520 HomoloGene: 5275 GeneCards: MME
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • zinc ion binding; • exopeptidase activity; • hydrolase activity; • endopeptidase activity; • metal ion binding; • GO:0070122 peptidase activity; • peptide binding; • metalloendopeptidase activity; • metallopeptidase activity; • phosphatidylserine binding; • protein homodimerization activity; • oligopeptidase activity; • cardiolipin binding;
Cydrannau o'r gell	• brush border; • focal adhesion; • integral component of plasma membrane; • cytoplasm; • bilen; • extracellular exosome; • integral component of membrane; • synaptic vesicle; • Cellbilen; • synapse; • axon; • dendrite; • neuron projection terminus; • secretory granule membrane; • early endosome; • trans-Golgi network; • cell surface; • GO:0016023 cytoplasmic vesicle; • soma; • membrane raft; • presynapse;
Prosesau biolegol	• angiotensin maturation; • cellular response to UV-B; • cellular response to cytokine stimulus; • kidney development; • replicative senescence; • cellular response to UV-A; • creatinine metabolic process; • peptide metabolic process; • amyloid-beta metabolic process; • proteolysis; • sensory perception of pain; • neutrophil degranulation; • placenta development; • GO:0010260 heneiddio; • learning or memory; • lung development; • positive regulation of neurogenesis; • neuropeptide processing; • amyloid-beta clearance; • amyloid-beta clearance by cellular catabolic process; • positive regulation of long-term synaptic potentiation;
	Sources:Amigo / QuickGO
Orthologau
	4311
	n/a
	ENSG00000196549
	n/a
	P08473; Q3KQS6
	n/a
NM_000902; NM_007287; NM_007288; NM_007289; NM_001354642;
	NM_001354643; NM_001354644
	n/a
NP_000893; NP_009218; NP_009219; NP_009220; NP_001341571;
	NP_001341572; NP_001341573
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MME yw MME a elwir hefyd yn Neprilysin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q25.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MME.

NEP
SFE
CD10
CALLA
CMT2T
SCA43

Llyfryddiaeth

"CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine. ". Cancer Sci. 2016. PMID 27513891.
"Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2. ". Ann Neurol. 2016. PMID 26991897.
"CD10-Equipped Melanoma Cells Acquire Highly Potent Tumorigenic Activity: A Plausible Explanation of Their Significance for a Poor Prognosis. ". PLoS One. 2016. PMID 26881775.
"CD10 expression in the neuroendocrine carcinoma component of endometrial mixed carcinoma: association with long survival. ". Diagn Pathol. 2016. PMID 26830028.
"Haematological profile of 21 patients with hairy cell leukaemia in a tertiary care centre of north India.". Indian J Med Res. 2015. PMID 26609034.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] MME - Cronfa NCBI

[1]

[2]