LRRK2 Dynodwyr Cyfenwau LRRK2 Dynodwyr allanol OMIM: 609007 HomoloGene: 18982 GeneCards: LRRK2 EC number 2.7.11.1 Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • signaling receptor complex adaptor activity • clathrin binding • co-receptor binding • transferase activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • protein kinase activity • protein kinase A binding • peroxidase inhibitor activity • SNARE binding • nucleotide binding • identical protein binding • GO:0006184 GTPase activity • syntaxin-1 binding • protein serine/threonine kinase activity • tubulin binding • transmembrane transporter binding • microtubule binding • MAP kinase kinase activity • GTP binding • ATP binding • GTP-dependent protein kinase activity • beta-catenin destruction complex binding • GO:0001948, GO:0016582 protein binding • kinase activity • actin binding • magnesium ion binding Cydrannau o'r gell • GO:0016023 cytoplasmic vesicle • endosome • extracellular exosome • Wnt signalosome • soma • trans-Golgi network • mitochondrial membranes • synapse • cytoplasm • mitochondrial outer membrane • synaptic vesicle membrane • perikaryon • Reticwlwm endoplasmig • Cellbilen • microvillus • mitochondrial matrix • dendrite cytoplasm • growth cone • cell projection • dendrite • lysosome • neuron projection • Golgi-associated vesicle • mitocondria • mitochondrial inner membrane • autolysosome • terminal bouton • intracellular anatomical structure • bilen • membrane raft • axon • amphisome • multivesicular body, internal vesicle • synaptic vesicle • inclusion body • cell junction • cytoplasmic side of mitochondrial outer membrane • cytosol • Golgi apparatus • postsynapse • extracellular space • cnewyllyn cell • intracellular membrane-bounded organelle • caveola neck • endoplasmic reticulum exit site • glutamatergic synapse • presynaptic cytosol • ribonucleoprotein complex Prosesau biolegol • lysosome organization • GO:0001306 response to oxidative stress • cellular response to dopamine • regulation of autophagy • positive regulation of autophagy • positive regulation of dopamine receptor signaling pathway • regulation of neuroblast proliferation • intracellular distribution of mitochondria • negative regulation of protein processing • negative regulation of protein processing involved in protein targeting to mitochondrion • protein localization to mitochondrion • positive regulation of canonical Wnt signaling pathway • autophagy • neuromuscular junction development • phosphorylation • positive regulation of protein binding • regulation of branching morphogenesis of a nerve • mitochondrion localization • positive regulation of protein autoubiquitination • regulation of synaptic vesicle transport • positive regulation of protein phosphorylation • regulation of kidney size • regulation of synaptic vesicle exocytosis • positive regulation of MAP kinase activity • peptidyl-threonine phosphorylation • MAPK cascade • Wnt signalosome assembly • protein phosphorylation • regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • negative regulation of hydrogen peroxide-induced cell death • regulation of dopamine receptor signaling pathway • regulation of membrane potential • protein autophosphorylation • regulation of mitochondrial fission • regulation of neuron maturation • reactive oxygen species metabolic process • positive regulation of programmed cell death • regulation of neuron death • regulation of mitochondrial depolarization • cellular response to oxidative stress • negative regulation of late endosome to lysosome transport • GO:0007243 intracellular signal transduction • regulation of lysosomal lumen pH • GO:0034259 negative regulation of GTPase activity • locomotory exploration behavior • Golgi organization • canonical Wnt signaling pathway • neuron projection morphogenesis • positive regulation of protein ubiquitination • regulation of canonical Wnt signaling pathway • exploration behavior • GO:1904579 cellular response to organic cyclic compound • tangential migration from the subventricular zone to the olfactory bulb • regulation of protein kinase A signaling • calcium-mediated signaling • negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of neuron death • negative regulation of protein targeting to mitochondrion • GO:0035404 peptidyl-serine phosphorylation • determination of adult lifespan • negative regulation of excitatory postsynaptic potential • GO:0033128 negative regulation of protein phosphorylation • neuron death • GTP metabolic process • negative regulation of autophagosome assembly • olfactory bulb development • cellular response to starvation • regulation of dendritic spine morphogenesis • cell differentiation • endocytosis • negative regulation of protein binding • mitochondrion organization • cellular response to manganese ion • negative regulation of macroautophagy • regulation of locomotion • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • regulation of retrograde transport, endosome to Golgi • regulation of CAMKK-AMPK signaling cascade • positive regulation of histone deacetylase activity • endoplasmic reticulum organization • spermatogenesis • regulation of gene expression • negative regulation of neuron projection development • striatum development • regulation of protein stability • positive regulation of nitric-oxide synthase biosynthetic process • regulation of ER to Golgi vesicle-mediated transport • protein localization to endoplasmic reticulum exit site • neuron projection arborization • regulation of synaptic vesicle endocytosis • positive regulation of synaptic vesicle endocytosis • positive regulation of microglial cell activation • protein import into nucleus Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn LRRK2 yw LRRK2 a elwir hefyd yn Leucine-rich repeat serine/threonine-protein kinase 2 a Leucine rich repeat kinase 2 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q12.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LRRK2.
PARK8
RIPK7
ROCO2
AURA17
DARDARIN
"Evidence for prehistoric origins of the G2019S mutation in the North African Berber population. ". PLoS One . 2017. PMID 28723952 . "Prospective clinical and DaT-SPECT imaging in premotor LRRK2G2019S-associated Parkinson disease. ". Neurology . 2017. PMID 28679601 . "DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers. ". PLoS One . 2017. PMID 28406934 . "Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology. ". eNeuro . 2017. PMID 28321439 . "LRRK2 detection in human biofluids: potential use as a Parkinson's disease biomarker?". Biochem Soc Trans. 2017. PMID 28202674 . 
