LIG1

LIG1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1X9N
Dynodwyr
Cyfenwau	LIG1, DNA ligase 1, LIGI, hLig1, IMD96
Dynodwyr allanol	OMIM: 126391 HomoloGene: 197 GeneCards: LIG1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nucleotide binding; • DNA ligase (ATP) activity; • metal ion binding; • ligase activity; • ATP binding; • DNA ligase activity;
Cydrannau o'r gell	• intracellular membrane-bounded organelle; • nucleoplasm; • mitocondria; • cnewyllyn cell; • cytoplasm;
Prosesau biolegol	• nucleotide-excision repair, DNA gap filling; • DNA recombination; • DNA biosynthetic process; • anatomical structure morphogenesis; • Okazaki fragment processing involved in mitotic DNA replication; • cellular response to DNA damage stimulus; • Cellraniad; • DNA replication; • V(D)J recombination; • DNA mismatch repair; • DNA ligation involved in DNA repair; • cell cycle; • transcription-coupled nucleotide-excision repair; • GO:0100026 DNA repair; • base-excision repair; • DNA ligation; • lagging strand elongation;
	Sources:Amigo / QuickGO
Orthologau
	3978
	n/a
	ENSG00000105486
	n/a
	P18858
	n/a
	NM_000234; NM_001289063; NM_001289064; NM_001320970; NM_001320971
	n/a
	NP_000225; NP_001275992; NP_001275993; NP_001307899; NP_001307900
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIG1 yw LIG1 a elwir hefyd yn DNA ligase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.33.^[2]

Llyfryddiaeth

"Association Between the LIG1 Polymorphisms and Lung Cancer Risk: A Meta-analysis of Case-Control Studies. ". Cell Biochem Biophys. 2015. PMID 27352326.
"Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. ". PLoS One. 2015. PMID 26151554.
"Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity. ". Genet Mol Res. 2015. PMID 26125914.
"LIG1 polymorphisms: the Indian scenario. ". J Genet. 2014. PMID 25189241.
"Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women.". Exp Oncol. 2013. PMID 24084463.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LIG1 - Cronfa NCBI

[1]

[2]