LCN2

LCN2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DFV, 1L6M, 1NGL, 1QQS, 1X71, 1X89, 1X8U, 3BY0, 3CBC, 3CMP, 3DSZ, 3DTQ, 3FW4, 3FW5, 3HWD, 3HWE, 3HWF, 3HWG, 3I0A, 3K3L, 3PEC, 3PED, 3T1D, 3TF6, 3TZS, 3U03, 3U0D, 4GH7, 4IAW, 4IAX, 4K19, 4MVI, 4MVK, 4MVL, 4QAE, 4ZFX, 4ZHC, 4ZHD, 4ZHF, 4ZHG, 4ZHH
Dynodwyr
Cyfenwau	LCN2, 24p3, MSFI, NGAL, p25, lipocalin 2
Dynodwyr allanol	OMIM: 600181 HomoloGene: 4064 GeneCards: LCN2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transporter activity; • small molecule binding; • protease binding; • iron ion binding; • protein homodimerization activity; • enterobactin binding;
Cydrannau o'r gell	• extracellular exosome; • extracellular space; • cytosol; • specific granule lumen; • extracellular region; • GO:0016023 cytoplasmic vesicle; • cytoplasmic vesicle lumen;
Prosesau biolegol	• immune system process; • iron ion homeostasis; • cludo ïon; • innate immune response; • cellular iron ion homeostasis; • GO:0097285 apoptotic process; • GO:0001306 response to oxidative stress; • response to virus; • response to bacterium; • response to herbicide; • response to mycotoxin; • GO:1901313 positive regulation of gene expression; • siderophore transport; • antimicrobial humoral response; • positive regulation of cell projection organization; • response to nutrient levels; • cellular response to nutrient levels; • neutrophil degranulation; • protein homotrimerization; • cellular response to hydrogen peroxide; • cellular response to lipopolysaccharide; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • extrinsic apoptotic signaling pathway in absence of ligand; • GO:0015915 transport; • cytokine-mediated signaling pathway; • defense response to bacterium; • sequestering of iron ion; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologau
	3934
	n/a
	ENSG00000148346
	n/a
	P80188
	n/a
	NM_005564
	n/a
	NP_005555
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LCN2 yw LCN2 a elwir hefyd yn Lipocalin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.11.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LCN2.

p25
24p3
MSFI
NGAL

Llyfryddiaeth

"Ascites Neutrophil Gelatinase-Associated Lipocalin Identifies Spontaneous Bacterial Peritonitis and Predicts Mortality in Hospitalized Patients with Cirrhosis. ". Dig Dis Sci. 2017. PMID 29098551.
"Assessment of pN-GAL as a marker of renal function in elite cyclists during professional competitions. ". J Biol Regul Homeost Agents. 2017. PMID 28958144.
"Urinary RBP and NGAL Levels are Associated with Nephropathy in Patients with Type 2 Diabetes. ". Cell Physiol Biochem. 2017. PMID 28954270.
"Lipocalin 2 negatively regulates cell proliferation and epithelial to mesenchymal transition through changing metabolic gene expression in colorectal cancer. ". Cancer Sci. 2017. PMID 28859238.
"Serum neutrophil gelatinase-associated lipocalin the estimation of hospital prognosis in patients with ST-elevated myocardial infarction.". PLoS One. 2017. PMID 28742104.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] LCN2 - Cronfa NCBI

[1]

[2]