ITGA2B

ITGA2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N
Dynodwyr
Cyfenwau	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
Dynodwyr allanol	OMIM: 607759 HomoloGene: 37304 GeneCards: ITGA2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • fibrinogen binding • extracellular matrix binding • identical protein binding • metal ion binding Cydrannau o'r gell • focal adhesion • integrin complex • integral component of plasma membrane • platelet alpha granule membrane • integral component of membrane • bilen • external side of plasma membrane • extracellular exosome • Cellbilen • blood microparticle • cell surface Prosesau biolegol • extracellular matrix organization • cell-matrix adhesion • positive regulation of leukocyte migration • platelet aggregation • platelet degranulation • cell adhesion • integrin-mediated signaling pathway • regulation of megakaryocyte differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3674	n/a
Ensembl	ENSG00000005961	n/a
UniProt	P08514	n/a
RefSeq (mRNA)	NM_000419	n/a
RefSeq (protein)	NP_000410	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGA2B yw ITGA2B a elwir hefyd yn Integrin subunit alpha 2b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGA2B.

• GT
• GTA
• CD41
• GP2B
• HPA3
• CD41B
• GPIIb
• BDPLT2
• BDPLT16
• PPP1R93

Llyfryddiaeth

• "Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3. ". Biochemistry. 2017. PMID 28277676.
• "The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. ". J Biol Chem. 2014. PMID 24338009.
• "PlA(1)/PlA(2) polymorphism does not influence response to Gp IIb-IIIa inhibitors in patients undergoing coronary angioplasty. ". Blood Coagul Fibrinolysis. 2013. PMID 23412353.
• "PLA2 polymorphism of platelet glycoprotein IIb/IIIa but not Factor V Leiden and prothrombin G20210A polymorphisms is associated with venous thromboembolism and more recurrent events in central Iran. ". Blood Coagul Fibrinolysis. 2013. PMID 23358226.
• "A V740L mutation in glycoprotein IIb defines a novel epitope (War) associated with fetomaternal alloimmune thrombocytopenia.". Transfusion. 2013. PMID 23305224.