IHH

IHH
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3K7G, 3K7H, 3K7I, 3K7J, 3N1F, 3N1M, 3N1O, 3N1P
Dynodwyr
Cyfenwau	IHH, BDA1, HHG2, indian hedgehog, Indian hedgehog signaling molecule
Dynodwyr allanol	OMIM: 600726 HomoloGene: 22586 GeneCards: IHH
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • metal ion binding; • GO:0070122 peptidase activity; • hydrolase activity; • patched binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• bilen; • Cellbilen; • extracellular region; • extracellular space; • GO:0005578 extracellular matrix;
Prosesau biolegol	• response to estradiol; • maternal process involved in female pregnancy; • positive regulation of epithelial cell proliferation; • cell-cell signaling; • negative regulation of apoptotic process; • proteolysis; • multicellular organism development; • intein-mediated protein splicing; • smoothened signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • skeletal system development; • ossification; • branching involved in blood vessel morphogenesis; • osteoblast differentiation; • in utero embryonic development; • cell fate specification; • morphogenesis of a branching structure; • vasculature development; • heart looping; • positive regulation of mesenchymal cell proliferation; • epithelial cell morphogenesis; • retinal pigment epithelium development; • chondrocyte differentiation involved in endochondral bone morphogenesis; • proteoglycan metabolic process; • pattern specification process; • positive regulation of cell population proliferation; • embryonic pattern specification; • cell differentiation; • vitelline membrane formation; • pancreas development; • positive regulation of collagen biosynthetic process; • negative regulation of T cell differentiation in thymus; • negative regulation of immature T cell proliferation in thymus; • positive regulation of T cell differentiation in thymus; • multicellular organism growth; • chondrocyte proliferation; • regulation of growth; • embryonic digit morphogenesis; • camera-type eye development; • bone resorption; • negative regulation of cell differentiation; • positive regulation of smoothened signaling pathway; • positive regulation of alpha-beta T cell differentiation; • negative regulation of alpha-beta T cell differentiation; • negative regulation of eye pigmentation; • cell maturation; • embryonic digestive tract morphogenesis; • embryonic camera-type eye morphogenesis; • neuron development; • smooth muscle tissue development; • cartilage development; • camera-type eye photoreceptor cell fate commitment; • head morphogenesis; • somite development; • embryonic skeletal joint development; • epithelial cell-cell adhesion; • response to mechanical stimulus; • liver regeneration; • regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologau
	3549
	n/a
	ENSG00000163501
	n/a
	Q14623
	n/a
	NM_002181
	n/a
	NP_002172
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IHH yw IHH a elwir hefyd yn Indian hedgehog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IHH.

BDA1
HHG2

Llyfryddiaeth

"Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. ". Arthritis Res Ther. 2015. PMID 26705100.
"Indian hedgehog contributes to human cartilage endplate degeneration. ". Eur Spine J. 2015. PMID 25958162.
"Identification of the fourth duplication of upstream IHH regulatory elements, in a family with craniosynostosis Philadelphia type, helps to define the phenotypic characterization of these regulatory elements. ". Am J Med Genet A. 2015. PMID 25692887.
"Endogenously produced Indian Hedgehog regulates TGFβ-driven chondrogenesis of human bone marrow stromal/stem cells. ". Stem Cells Dev. 2015. PMID 25519748.
"Indian hedgehog signaling promotes chondrocyte differentiation in enchondral ossification in human cervical ossification of the posterior longitudinal ligament.". Spine (Phila Pa 1976). 2013. PMID 23883825.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IHH - Cronfa NCBI

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[2]