HLA-E

HLA-E
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG
Dynodwyr
Cyfenwau	HLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
Dynodwyr allanol	OMIM: 143010 HomoloGene: 134018 GeneCards: HLA-E
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• beta-2-microglobulin binding; • MHC class I protein binding; • signaling receptor binding; • natural killer cell lectin-like receptor binding; • peptide antigen binding; • T cell receptor binding;
Cydrannau o'r gell	• integral component of membrane; • phagocytic vesicle membrane; • early endosome membrane; • bilen; • MHC class Ib protein complex; • Golgi membrane; • Cellbilen; • cell surface; • MHC class I protein complex; • ER to Golgi transport vesicle membrane; • integral component of lumenal side of endoplasmic reticulum membrane; • extracellular exosome; • recycling endosome membrane;
Prosesau biolegol	• antigen processing and presentation; • adaptive immune response; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • CD8-positive, alpha-beta T cell activation; • interferon-gamma-mediated signaling pathway; • immune system process; • antigen processing and presentation of peptide antigen via MHC class I; • positive regulation of T cell mediated cytotoxicity; • positive regulation of TRAIL production; • positive regulation of interleukin-4 production; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; • protection from natural killer cell mediated cytotoxicity; • positive regulation of interleukin-13 production; • type I interferon signaling pathway; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • regulation of natural killer cell mediated immunity; • positive regulation of natural killer cell mediated immunity; • regulation of immune response; • positive regulation of tumor necrosis factor production; • innate immune response; • positive regulation of CD8-positive, alpha-beta T cell proliferation; • antigen processing and presentation of endogenous peptide antigen via MHC class Ib;
	Sources:Amigo / QuickGO
Orthologau
	3133
	n/a
ENSG00000204592; ENSG00000225201; ENSG00000236632; ENSG00000230254; ENSG00000206493;
	ENSG00000233904; ENSG00000229252
	n/a
	P13747
	n/a
	NM_005516
	n/a
	NP_005507
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-E yw HLA-E a elwir hefyd yn Major histocompatibility complex, class I, E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-E.

QA1
HLA-6.2

Llyfryddiaeth

"The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment. ". Eur J Cancer. 2017. PMID 29059634.
"HLA-E regulatory and coding region variability and haplotypes in a Brazilian population sample. ". Mol Immunol. 2017. PMID 28946074.
"Association of high HLA-E expression during acute cellular rejection and numbers of HLA class I leader peptide mismatches with reduced renal allograft survival. ". Immunobiology. 2017. PMID 27871782.
"HLA-E allelic genotype correlates with HLA-E plasma levels and predicts early progression in chronic lymphocytic leukemia. ". Cancer. 2017. PMID 27859015.
"Is HLA-E a possible genetic marker relevant for natural conception?". Am J Reprod Immunol. 2016. PMID 27714943.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HLA-E - Cronfa NCBI

[1]

[2]