FGFR2

FGFR2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1
Dynodwyr
Cyfenwau	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
Dynodwyr allanol	OMIM: 176943 HomoloGene: 22566 GeneCards: FGFR2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • kinase activity; • transmembrane receptor protein tyrosine kinase activity; • fibroblast growth factor binding; • ATP binding; • protein kinase activity; • fibroblast growth factor-activated receptor activity; • transferase activity; • protein homodimerization activity; • GO:0001948, GO:0016582 protein binding; • nucleotide binding; • protein tyrosine kinase activity; • 1-phosphatidylinositol-3-kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • identical protein binding; • receptor tyrosine kinase; • transmembrane signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • bilen; • extracellular region; • cnewyllyn cell; • cell surface; • integral component of membrane; • Golgi apparatus; • intracellular membrane-bounded organelle; • GO:0005578 extracellular matrix; • Cellbilen; • nucleoplasm; • cell cortex; • integral component of plasma membrane; • excitatory synapse; • GO:0016023 cytoplasmic vesicle; • receptor complex; • collagen-containing extracellular matrix;
Prosesau biolegol	• fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; • ureteric bud development; • organ growth; • limb bud formation; • embryonic pattern specification; • bud elongation involved in lung branching; • positive regulation of canonical Wnt signaling pathway; • membranous septum morphogenesis; • fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; • embryonic organ morphogenesis; • post-embryonic development; • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; • branching morphogenesis of a nerve; • reproductive structure development; • fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; • ventricular cardiac muscle tissue morphogenesis; • protein phosphorylation; • positive regulation of cardiac muscle cell proliferation; • mesenchymal cell differentiation; • positive regulation of mesenchymal cell proliferation; • regulation of osteoblast differentiation; • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; • angiogenesis; • prostate gland morphogenesis; • positive regulation of ERK1 and ERK2 cascade; • orbitofrontal cortex development; • negative regulation of epithelial cell proliferation; • animal organ morphogenesis; • embryonic digestive tract morphogenesis; • hair follicle morphogenesis; • morphogenesis of embryonic epithelium; • branch elongation involved in salivary gland morphogenesis; • GO:0097285 apoptotic process; • branching involved in salivary gland morphogenesis; • cell fate commitment; • lung development; • embryonic organ development; • fibroblast growth factor receptor signaling pathway involved in hemopoiesis; • in utero embryonic development; • lateral sprouting from an epithelium; • positive regulation of Wnt signaling pathway; • gland morphogenesis; • positive regulation of cell cycle; • branching involved in labyrinthine layer morphogenesis; • branching involved in prostate gland morphogenesis; • regulation of ERK1 and ERK2 cascade; • protein autophosphorylation; • mammary gland bud formation; • pyramidal neuron development; • lacrimal gland development; • positive regulation of MAPK cascade; • regulation of smooth muscle cell differentiation; • regulation of cell fate commitment; • bone mineralization; • regulation of branching involved in prostate gland morphogenesis; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • epithelial cell differentiation; • phosphorylation; • multicellular organism growth; • positive regulation of epithelial cell proliferation; • ventricular zone neuroblast division; • epidermis morphogenesis; • skeletal system morphogenesis; • regulation of morphogenesis of a branching structure; • GO:1901227 negative regulation of transcription by RNA polymerase II; • outflow tract septum morphogenesis; • odontogenesis; • epithelial to mesenchymal transition; • lung alveolus development; • lung lobe morphogenesis; • midbrain development; • positive regulation of smooth muscle cell proliferation; • fibroblast growth factor receptor signaling pathway involved in mammary gland specification; • mesenchymal cell proliferation involved in lung development; • prostate epithelial cord elongation; • mesenchymal cell differentiation involved in lung development; • axonogenesis; • regulation of multicellular organism growth; • otic vesicle formation; • epithelial cell proliferation involved in salivary gland morphogenesis; • cell-cell signaling; • regulation of fibroblast growth factor receptor signaling pathway; • bone morphogenesis; • MAPK cascade; • regulation of osteoblast proliferation; • positive regulation of phospholipase activity; • fibroblast growth factor receptor signaling pathway; • regulation of smoothened signaling pathway; • inner ear morphogenesis; • positive regulation of cell population proliferation; • mesodermal cell differentiation; • peptidyl-tyrosine phosphorylation; • digestive tract development; • lung-associated mesenchyme development; • bone development; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • phosphatidylinositol phosphate biosynthetic process; • phosphatidylinositol-3-phosphate biosynthetic process; • endochondral bone growth; • response to lipopolysaccharide; • wound healing; • cellular response to fibroblast growth factor stimulus; • response to ethanol; • cellular response to retinoic acid; • cellular response to transforming growth factor beta stimulus; • embryonic cranial skeleton morphogenesis; • positive regulation of protein kinase B signaling; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	2263
	n/a
	ENSG00000066468
	n/a
	P21802
	n/a
NM_000141; NM_001144913; NM_001144914; NM_001144915; NM_001144916;
	NM_001144917; NM_001144918; NM_001144919; NM_022970; NM_022971; NM_022972; NM_022973; NM_022974; NM_022975; NM_022976; NM_023028; NM_023029; NM_023030; NM_001320654; NM_001320658; NM_023031
	n/a
NP_000132; NP_001138385; NP_001138386; NP_001138387; NP_001138388;
	NP_001138389; NP_001138390; NP_001138391; NP_001307583; NP_001307587; NP_075259; NP_075418
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGFR2 yw FGFR2 a elwir hefyd yn Fibroblast growth factor receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q26.13.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGFR2.

BEK
JWS
BBDS
CEK3
CFD1
ECT1
KGFR
TK14
TK25
BFR-1
CD332
K-SAM

Llyfryddiaeth

"Prognostic role of fibroblast growth factor receptor 2 in human solid tumors: A systematic review and meta-analysis. ". Tumour Biol. 2017. PMID 28618942.
"FGFR2 mutations are associated with poor outcomes in endometrioid endometrial cancer: An NRG Oncology/Gynecologic Oncology Group study. ". Gynecol Oncol. 2017. PMID 28314589.
"Effects of FGFR2 kinase activation loop dynamics on catalytic activity. ". PLoS Comput Biol. 2017. PMID 28151998.
"Investigation of G-quadruplex formation in the FGFR2 promoter region and its transcriptional regulation by liensinine. ". Biochim Biophys Acta. 2017. PMID 28132898.
"Acquired resistance to LY2874455 in FGFR2-amplified gastric cancer through an emergence of novel FGFR2-ACSL5 fusion.". Oncotarget. 2017. PMID 28122360.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] FGFR2 - Cronfa NCBI

[1]

[2]