EPHA3

EPHA3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2GSF, 2QO7, 2QO9, 2QOB, 2QOC, 2QOD, 2QOF, 2QOI, 2QOK, 2QOL, 2QON, 2QOO, 2QOQ, 3DZQ, 3FXX, 3FY2, 4G2F, 4GK2, 4GK3, 4GK4, 4L0P, 4P4C, 4P5Q, 4P5Z, 4TWN, 4TWO
Dynodwyr
Cyfenwau	EPHA3, Epha3, AW492086, Cek4, ETK1, End3, Hek, Hek4, Mek4, Tyro4, EK4, ETK, EPH receptor A3, HEK, HEK4, TYRO4
Dynodwyr allanol	OMIM: 179611 HomoloGene: 21083 GeneCards: EPHA3
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • GPI-linked ephrin receptor activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • receptor tyrosine kinase; • transmembrane signaling receptor activity; • transmembrane-ephrin receptor activity;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • integral component of plasma membrane; • extracellular region; • early endosome; • cytoplasm; • neuron projection; • receptor complex;
Prosesau biolegol	• cellular response to retinoic acid; • regulation of actin cytoskeleton organization; • fasciculation of motor neuron axon; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • regulation of epithelial to mesenchymal transition; • regulation of microtubule cytoskeleton organization; • protein phosphorylation; • cell adhesion; • positive regulation of neuron projection development; • regulation of focal adhesion assembly; • fasciculation of sensory neuron axon; • cell migration; • ephrin receptor signaling pathway; • peptidyl-tyrosine phosphorylation; • negative regulation of endocytosis; • positive regulation of protein localization to plasma membrane; • negative regulation of signal transduction; • cell differentiation; • negative regulation of apoptotic process; • positive regulation of ERK1 and ERK2 cascade; • axon guidance;
	Sources:Amigo / QuickGO
Orthologau
	2042
	n/a
	ENSG00000044524
	n/a
	P29320
	n/a
	NM_005233; NM_182644
	n/a
	NP_005224; NP_872585
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA3 yw EPHA3 a elwir hefyd yn EPH receptor A3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p11.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA3.

EK4
ETK
HEK
ETK1
HEK4
TYRO4

Llyfryddiaeth

"Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth. ". PLoS One. 2014. PMID 25420155.
"Genome-wide copy number variation in sporadic amyotrophic lateral sclerosis in the Turkish population: deletion of EPHA3 is a possible protective factor. ". PLoS One. 2013. PMID 23991104.
"Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma. ". Clin Genitourin Cancer. 2017. PMID 27591824.
"Germline copy number variation analysis in Finnish families with hereditary prostate cancer. ". Prostate. 2016. PMID 26552734.
"Unliganded EphA3 dimerization promoted by the SAM domain.". Biochem J. 2015. PMID 26232493.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPHA3 - Cronfa NCBI

[1]

[2]