ENPP2

ENPP2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4ZGA, 4ZG6, 4ZG9, 4ZG7
Dynodwyr
Cyfenwau	ENPP2, ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
Dynodwyr allanol	OMIM: 601060 HomoloGene: 4526 GeneCards: ENPP2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide diphosphatase activity; • phosphodiesterase I activity; • transcription factor binding; • polysaccharide binding; • metal ion binding; • scavenger receptor activity; • catalytic activity; • alkylglycerophosphoethanolamine phosphodiesterase activity; • nucleic acid binding; • hydrolase activity; • calcium ion binding; • lysophospholipase activity; • zinc ion binding;
Cydrannau o'r gell	• Cellbilen; • integral component of plasma membrane; • extracellular region; • extracellular space; • cytoplasm; • Golgi apparatus;
Prosesau biolegol	• G protein-coupled receptor signaling pathway; • regulation of cell migration; • positive regulation of lamellipodium morphogenesis; • lipid metabolism; • positive regulation of epithelial cell migration; • regulation of angiogenesis; • receptor-mediated endocytosis; • lipid catabolic process; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • phospholipid catabolic process; • positive regulation of peptidyl-tyrosine phosphorylation; • phosphate-containing compound metabolic process; • metabolaeth; • chemotaxis; • phosphatidylcholine catabolic process; • nucleic acid phosphodiester bond hydrolysis; • cell motility; • phospholipid metabolic process; • negative regulation of cell-matrix adhesion; • positive regulation of cell population proliferation; • diencephalon development; • forebrain development; • midbrain development; • positive regulation of oligodendrocyte differentiation; • positive regulation of focal adhesion assembly; • cell chemotaxis; • cellular response to cadmium ion; • cellular response to estradiol stimulus; • positive regulation of substrate adhesion-dependent cell spreading; • response to polycyclic arene; • vesicle-mediated transport; • endocytosis;
	Sources:Amigo / QuickGO
Orthologau
	5168
	n/a
	ENSG00000136960
	n/a
	Q13822
	n/a
	NM_001040092; NM_001130863; NM_006209; NM_001330600
	n/a
	NP_001035181; NP_001124335; NP_001317529; NP_006200
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ENPP2 yw ENPP2 a elwir hefyd yn Ectonucleotide pyrophosphatase/phosphodiesterase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ENPP2.

ATX
NPP2
ATX-X
PDNP2
LysoPLD
AUTOTAXIN
PD-IALPHA

Llyfryddiaeth

"The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer. ". Tumour Biol. 2017. PMID 28347252.
"Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia. ". PLoS One. 2017. PMID 28052132.
"Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression. ". Med Oncol. 2016. PMID 27757783.
"During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy. ". J Infect Dis. 2016. PMID 27540113.
"Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.". J Struct Biol. 2016. PMID 27268273.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ENPP2 - Cronfa NCBI

[1]

[2]