EGR2

EGR2
Dynodwyr
Cyfenwau	EGR2, AT591, CMT1D, CMT4E, KROX20, early growth response 2, CHN1
Dynodwyr allanol	OMIM: 129010 HomoloGene: 20123 GeneCards: EGR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • HMG box domain binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • ubiquitin protein ligase binding • transferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • SUMO ligase activity Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm • intracellular membrane-bounded organelle Prosesau biolegol • cellular response to organic substance • rhythmic behavior • peripheral nervous system development • GO:0009373 regulation of transcription, DNA-templated • rhombomere 3 development • brain segmentation • transcription by RNA polymerase II • protein sumoylation • rhombomere 3 formation • transcription, DNA-templated • response to insulin • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • brain development • rhombomere 5 formation • protein export from nucleus • learning or memory • skeletal muscle cell differentiation • Schwann cell differentiation • regulation of neuronal synaptic plasticity • myelination • facial nerve structural organization • regulation of ossification • motor neuron axon guidance • fat cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1959	n/a
Ensembl	ENSG00000122877	n/a
UniProt	P11161	n/a
RefSeq (mRNA)	NM_000399 NM_001136177 NM_001136178 NM_001136179 NM_001321037	n/a
RefSeq (protein)	NP_000390 NP_001129649 NP_001129650 NP_001129651 NP_001307966	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EGR2 yw EGR2 a elwir hefyd yn Early growth response 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EGR2.

• AT591
• CMT1D
• CMT4E
• KROX20

Llyfryddiaeth

• "Identification of zinc finger transcription factor EGR2 as a novel acetylated protein. ". Biochem Biophys Res Commun. 2017. PMID 28576496.
• "Expression of Early Growth Response Gene-2 and Regulated Cytokines Correlates with Recovery from Guillain-Barré Syndrome. ". J Immunol. 2016. PMID 26718337.
• "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. ". Nat Genet. 2015. PMID 26214589.
• "The EGR2 gene is involved in axonal Charcot-Marie-Tooth disease. ". Eur J Neurol. 2015. PMID 26204789.
• "Resequencing of early growth response 2 (EGR2) gene revealed a recurrent patient-specific mutation in schizophrenia.". Psychiatry Res. 2015. PMID 26119399.