CYP1A2

CYP1A2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2HI4
Dynodwyr
Cyfenwau	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
Dynodwyr allanol	OMIM: 124060 HomoloGene: 68082 GeneCards: CYP1A2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• iron ion binding; • demethylase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; • metal ion binding; • caffeine oxidase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • enzyme binding; • oxidoreductase activity; • aromatase activity; • electron transfer activity; • monooxygenase activity;
Cydrannau o'r gell	• organelle membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • bilen; • Reticwlwm endoplasmig;
Prosesau biolegol	• response to immobilization stress; • toxin metabolic process; • steroid metabolic process; • response to estradiol; • alkaloid metabolic process; • GO:1904578 response to organic cyclic compound; • lung development; • lipid metabolism; • epoxygenase P450 pathway; • cellular response to cadmium ion; • post-embryonic development; • monocarboxylic acid metabolic process; • response to organic substance; • oxidative demethylation; • response to lipopolysaccharide; • methylation; • steroid catabolic process; • omega-hydroxylase P450 pathway; • dibenzo-p-dioxin metabolic process; • heterocycle metabolic process; • Resbiradaeth cellog; • cellular aromatic compound metabolic process; • regulation of gene expression; • hydrogen peroxide biosynthetic process; • monoterpenoid metabolic process; • xenobiotic metabolic process; • porphyrin-containing compound metabolic process; • toxin biosynthetic process; • cellular response to copper ion; • electron transport chain; • long-chain fatty acid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	1544
	n/a
	ENSG00000140505
	n/a
	P05177
	n/a
	NM_000761
	n/a
	NP_000752
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP1A2 yw CYP1A2 a elwir hefyd yn Cytochrome P450 family 1 subfamily A member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP1A2.

CP12
CYPIA2
P3-450
P450(PA)

Llyfryddiaeth

"Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. ". PLoS One. 2017. PMID 28934216.
"CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study. ". Nutrients. 2017. PMID 28287486.
"Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. ". Genet Mol Res. 2016. PMID 27323197.
"Dose validation of PhIP hair level as a biomarker of heterocyclic aromatic amines exposure: a feeding study. ". Carcinogenesis. 2016. PMID 27207666.
"Cigarette smoking has a differential effect on the plasma level of clozapine in Taiwanese schizophrenic patients associated with the CYP1A2 gene -163A/C single nucleotide polymorphism.". Psychiatr Genet. 2016. PMID 27203225.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CYP1A2 - Cronfa NCBI

[1]

[2]