CXCL10

CXCL10
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1O80, 1LV9, 1O7Y, 1O7Z
Dynodwyr
Cyfenwau	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
Dynodwyr allanol	OMIM: 147310 HomoloGene: 1203 GeneCards: CXCL10
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • GO:0001948, GO:0016582 protein binding; • cAMP-dependent protein kinase regulator activity; • signaling receptor binding; • chemoattractant activity;
Cydrannau o'r gell	• extracellular region; • external side of plasma membrane; • extracellular space; • intracellular anatomical structure;
Prosesau biolegol	• regulation of endothelial tube morphogenesis; • negative regulation of myoblast differentiation; • cellular response to heat; • response to vitamin D; • positive regulation of cell migration; • T cell chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • response to virus; • muscle organ development; • positive regulation of monocyte chemotaxis; • positive regulation of release of sequestered calcium ion into cytosol; • endothelial cell activation; • positive regulation of cAMP-mediated signaling; • regulation of T cell chemotaxis; • blood circulation; • chemotaxis; • positive regulation of leukocyte chemotaxis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • negative regulation of myoblast fusion; • defense response to virus; • regulation of cell population proliferation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive regulation of cell population proliferation; • response to auditory stimulus; • negative regulation of angiogenesis; • response to cold; • cellular response to lipopolysaccharide; • response to gamma radiation; • positive regulation of T cell migration; • GO:0072468 signal transduction; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of protein kinase activity; • defense response; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • response to bacterium; • neutrophil chemotaxis; • leukocyte chemotaxis; • positive chemotaxis; • regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologau
	3627
	n/a
	ENSG00000169245
	n/a
	P02778
	n/a
	NM_001565
	n/a
	NP_001556
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CXCL10 yw CXCL10 a elwir hefyd yn C-X-C motif chemokine ligand 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q21.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CXCL10.

C7
IFI10
INP10
IP-10
crg-2
mob-1
SCYB10
gIP-10

Llyfryddiaeth

"Plasma Interferon-Gamma-Inducible Protein 10 Level Associates With Abnormal Memory B Cells Phenotypes in Perinatal HIV Infection. ". Pediatr Infect Dis J. 2017. PMID 28419006.
"The association of urinary interferon-gamma inducible protein-10 (IP10/CXCL10) levels with kidney allograft rejection. ". Inflamm Res. 2017. PMID 28246678.
"Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker. ". Arthritis Res Ther. 2017. PMID 28148302.
"Staphylococcus aureusDownregulates IP-10 Production and Prevents Th1 Cell Recruitment. ". J Immunol. 2017. PMID 28122962.
"Elevated serum interferon Î³-inducible protein-10 in women with polycystic ovary syndrome.". Gynecol Endocrinol. 2017. PMID 28051885.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CXCL10 - Cronfa NCBI

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[2]