CHRNB2

CHRNB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2K58, 2K59, 2KSR, 2LM2
Dynodwyr
Cyfenwau	CHRNB2, EFNL3, nAChRB2, cholinergic receptor nicotinic beta 2 subunit
Dynodwyr allanol	OMIM: 118507 HomoloGene: 595 GeneCards: CHRNB2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• acetylcholine binding; • acetylcholine receptor activity; • ion channel activity; • GO:0001948, GO:0016582 protein binding; • ligand-gated ion channel activity; • protein heterodimerization activity; • extracellular ligand-gated ion channel activity; • acetylcholine-gated cation-selective channel activity; • transmembrane signaling receptor activity; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cydrannau o'r gell	• acetylcholine-gated channel complex; • integral component of membrane; • postsynaptic membrane; • bilen; • Cellbilen; • synapse; • cell junction; • external side of plasma membrane; • integral component of plasma membrane; • neuron projection; • plasma membrane raft; • dopaminergic synapse; • cholinergic synapse; • integral component of presynaptic membrane; • integral component of postsynaptic specialization membrane;
Prosesau biolegol	• visual learning; • regulation of synaptic transmission, dopaminergic; • adwaith i gocên; • smooth muscle contraction; • regulation of circadian sleep/wake cycle, REM sleep; • regulation of dopamine secretion; • response to hypoxia; • associative learning; • gwybyddiaeth; • locomotory behavior; • protein heterooligomerization; • central nervous system neuron axonogenesis; • optic nerve morphogenesis; • regulation of synapse assembly; • regulation of membrane potential; • response to nicotine; • membrane depolarization; • nervous system process; • synaptic transmission, cholinergic; • cludo ïon; • clyw; • learning; • Cof; • negative regulation of action potential; • regulation of dopamine metabolic process; • behavioral response to nicotine; • regulation of dendrite morphogenesis; • B cell activation; • neuromuscular synaptic transmission; • synaptic transmission involved in micturition; • positive regulation of dopamine secretion; • positive regulation of B cell proliferation; • regulation of circadian sleep/wake cycle, non-REM sleep; • vestibulocochlear nerve development; • conditioned taste aversion; • GO:0015915 transport; • social behavior; • action potential; • sensory perception of pain; • lateral geniculate nucleus development; • positive regulation of synaptic transmission, dopaminergic; • response to ethanol; • central nervous system projection neuron axonogenesis; • calcium ion transport; • GO:0072468 signal transduction; • golwg; • cludo transmembrane rhwng ïonau; • regulation of postsynaptic membrane potential; • excitatory postsynaptic potential; • acetylcholine receptor signaling pathway; • chemical synaptic transmission; • response to acetylcholine; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	1141
	n/a
	ENSG00000160716
	n/a
	P17787
	n/a
	NM_000748
	n/a
	NP_000739
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHRNB2 yw CHRNB2 a elwir hefyd yn Cholinergic receptor nicotinic beta 2 subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHRNB2.

EFNL3
nAChRB2

Llyfryddiaeth

"The possible role of maternal bonding style and CHRNB2 gene polymorphisms in nicotine dependence and related depressive phenotype. ". Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID 25640319.
"Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. ". Pharmacogenomics J. 2012. PMID 21606948.
"NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit. ". Biochim Biophys Acta. 2010. PMID 20441771.
"Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. ". Nicotine Tob Res. 2010. PMID 20371741.
"Nicotinic acetylcholine receptor beta2 subunit (CHRNB2) gene and short-term ability to quit smoking in response to nicotine patch.". Cancer Epidemiol Biomarkers Prev. 2009. PMID 19755656.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CHRNB2 - Cronfa NCBI

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[2]