CEACAM1

CEACAM1
Strwythurau
PDB	Human UniProt search: P13688 or M0R2K4 PDBe P13688,M0R2K4 RCSB
Rhestr o ddynodwyr PDB
	2GK2, 4QXW, 5DZL, 4WHD
Dynodwyr
Cyfenwau	CEACAM1, BGP, BGP1, BGPI, carcinoembryonic antigen related cell adhesion molecule 1, CEA cell adhesion molecule 1
Dynodwyr allanol	OMIM: 109770 HomoloGene: 128630 GeneCards: CEACAM1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • kinase binding; • protein homodimerization activity; • protein phosphatase binding; • protein tyrosine kinase binding; • filamin binding; • bile acid transmembrane transporter activity; • protein dimerization activity; • actin binding; • calmodulin binding; • molecular function; • identical protein binding;
Cydrannau o'r gell	• bilen; • integral component of membrane; • extracellular region; • integral component of plasma membrane; • extracellular exosome; • T cell receptor complex; • cell-cell junction; • cell surface; • Cellbilen; • adherens junction; • basal plasma membrane; • apical plasma membrane; • lateral plasma membrane; • cell junction; • transport vesicle membrane; • GO:0016023 cytoplasmic vesicle; • microvillus membrane; • specific granule membrane; • cell projection; • tertiary granule membrane;
Prosesau biolegol	• integrin-mediated signaling pathway; • cell migration; • angiogenesis; • leukocyte migration; • insulin catabolic process; • positive regulation of vasculogenesis; • cellular response to insulin stimulus; • negative regulation of cytotoxic T cell degranulation; • regulation of ERK1 and ERK2 cascade; • regulation of homophilic cell adhesion; • negative regulation of vascular permeability; • regulation of endothelial cell migration; • negative regulation of interleukin-1 production; • homophilic cell adhesion via plasma membrane adhesion molecules; • granulocyte colony-stimulating factor signaling pathway; • wound healing, spreading of cells; • negative regulation of hepatocyte proliferation; • negative regulation of granulocyte differentiation; • negative regulation of platelet aggregation; • blood vessel development; • negative regulation of lipid biosynthetic process; • bile acid and bile salt transport; • regulation of blood vessel remodeling; • negative regulation of T cell receptor signaling pathway; • negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; • regulation of cell growth; • insulin receptor internalization; • negative regulation of T cell mediated cytotoxicity; • regulation of sprouting angiogenesis; • negative regulation of protein kinase activity; • negative regulation of fatty acid biosynthetic process; • regulation of cell migration; • regulation of phosphatidylinositol 3-kinase signaling; • common myeloid progenitor cell proliferation; • regulation of epidermal growth factor receptor signaling pathway; • regulation of endothelial cell differentiation; • cell adhesion; • neutrophil degranulation; • cell-cell adhesion via plasma-membrane adhesion molecules;
	Sources:Amigo / QuickGO
Orthologau
	634
	n/a
	ENSG00000079385
	n/a
	Q3KRG8
	n/a
NM_001024912; NM_001184813; NM_001184815; NM_001184816; NM_001205344;
	NM_001712
	n/a
NP_001020083.1; NP_001020083; NP_001171742; NP_001171744; NP_001171745;
	NP_001192273; NP_001703
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CEACAM1 yw CEACAM1 a elwir hefyd yn Carcinoembryonic antigen related cell adhesion molecule 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CEACAM1.

BGP
BGP1
BGPI

Llyfryddiaeth

"CEACAM1 is associated with recurrence after hepatectomy for colorectal liver metastasis. ". J Surg Res. 2017. PMID 29180203.
"CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells. ". Cancer Med. 2017. PMID 28332308.
"Elevated Preoperative Serum CEA Level Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma Through the Epithelial-Mesenchymal Transition. ". Anticancer Res. 2017. PMID 28314278.
"Glycosylation Alters Dimerization Properties of a Cell-surface Signaling Protein, Carcinoembryonic Antigen-related Cell Adhesion Molecule 1 (CEACAM1). ". J Biol Chem. 2016. PMID 27471271.
"CEACAM1 is overexpressed in oral tumors and related to tumorigenesis.". Med Mol Morphol. 2017. PMID 27464654.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CEACAM1 - Cronfa NCBI

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[2]