CDKN1A Dynodwyr Cyfenwau CDKN1A , CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1ADynodwyr allanol OMIM: 116899 HomoloGene: 333 GeneCards: CDKN1A Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • ubiquitin protein ligase binding • cyclin binding • cyclin-dependent protein kinase activating kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein kinase inhibitor activity • protein kinase binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytoplasm • cytosol • cyclin-dependent protein kinase holoenzyme complex • PCNA-p21 complex • perinuclear region of cytoplasm • cnewyllyn cell • nucleoplasm • nucleolus • nuclear body • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to extracellular stimulus • signal transduction by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to heat • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell death • GO:1904578 response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • stress-induced premature senescence • positive regulation of fibroblast proliferation • replicative senescence • response to hyperoxia • response to corticosterone • cellular response to amino acid starvation • positive regulation of programmed cell death • negative regulation of apoptotic process • response to glucocorticoid • response to arsenic-containing substance • regulation of DNA biosynthetic process • response to organic substance • negative regulation of gene expression • cellular response to DNA damage stimulus • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of cell cycle • intrinsic apoptotic signaling pathway • cellular senescence • positive regulation of reactive oxygen species metabolic process • cellular response to UV-B • G2/M transition of mitotic cell cycle • positive regulation of B cell proliferation • negative regulation of cell growth • response to organonitrogen compound • animal organ regeneration • regulation of mitotic cell cycle • intestinal epithelial cell maturation • cellular response to ionizing radiation • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • response to toxic substance • response to UV • response to X-ray • negative regulation of cell population proliferation • protein stabilization • positive regulation of cyclin-dependent protein kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein kinase activity • cellular response to gamma radiation • negative regulation of cyclin-dependent protein kinase activity • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • negative regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN1A yw CDKN1A a elwir hefyd yn Cyclin dependent kinase inhibitor 1A (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN1A.
P21
CIP1
SDI1
WAF1
CAP20
CDKN1
MDA-6
p21CIP1
"Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer. ". J Pharmacol Sci . 2017. PMID 28757172 .
"p21: A Two-Faced Genome Guardian. ". Trends Mol Med . 2017. PMID 28279624 .
"Immunohistochemical study of p21 and Bcl-2 in leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. ". J Exp Ther Oncol . 2016. PMID 27849339 .
"Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells. ". Elife . 2016. PMID 27740454 .
"Modification of p21 level and cell cycle distribution by 50 Hz magnetic fields in human SH-SY5Y neuroblastoma cells. ". Int J Radiat Biol . 2017. PMID 27646005 .