CAND1

CAND1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1U6G, 4A0C
Dynodwyr
Cyfenwau	CAND1, TIP120, TIP120A, cullin associated and neddylation dissociated 1
Dynodwyr allanol	OMIM: 607727 HomoloGene: 10202 GeneCards: CAND1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • TBP-class protein binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cullin-RING ubiquitin ligase complex • Golgi apparatus • extracellular exosome • bilen • cnewyllyn cell • ubiquitin ligase complex • extracellular region • secretory granule lumen • ficolin-1-rich granule lumen • nucleoplasm • cytosol Prosesau biolegol • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • SCF complex assembly • cell differentiation • positive regulation of RNA polymerase II transcription preinitiation complex assembly • GO:0048553 negative regulation of catalytic activity • protein ubiquitination • neutrophil degranulation • cellular iron ion homeostasis • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55832	n/a
Ensembl	ENSG00000111530	n/a
UniProt	Q86VP6	n/a
RefSeq (mRNA)	NM_001329674 NM_001329675 NM_001329676 NM_018448	n/a
RefSeq (protein)	NP_001316603 NP_001316604 NP_001316605 NP_060918	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CAND1 yw CAND1 a elwir hefyd yn Cullin-associated NEDD8-dissociated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q14.3-q15.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CAND1.

• TIP120
• TIP120A

Llyfryddiaeth

• "Induced expression, localization, and chromosome mapping of a gene for the TBP-interacting protein 120A. ". Biochem Biophys Res Commun. 1999. PMID 10581176.
• "CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis. ". Int J Biochem Cell Biol. 2015. PMID 26219975.
• "Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements. ". ACS Chem Biol. 2017. PMID 28388044.
• "CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis. ". Biochim Biophys Acta. 2013. PMID 23328082.
• "miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.". Prostate Cancer Prostatic Dis. 2010. PMID 20820187.