CALCRL

CALCRL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3AQF, 3N7P, 3N7R, 3N7S, 4RWF
Dynodwyr
Cyfenwau	CALCRL, CGRPR, CRLR, calcitonin receptor like receptor, LMPHM8
Dynodwyr allanol	OMIM: 114190 HomoloGene: 21179 GeneCards: CALCRL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • calcitonin receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity • adrenomedullin receptor activity • calcitonin gene-related peptide receptor activity • adrenomedullin binding Cydrannau o'r gell • integral component of membrane • endosome • bilen • Cellbilen • integral component of plasma membrane • Reticwlwm endoplasmig • lysosome • cytoplasm • adrenomedullin receptor complex • CGRP receptor complex Prosesau biolegol • negative regulation of smooth muscle contraction • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor internalization • cellular response to sucrose stimulus • heart development • cell surface receptor signaling pathway • angiogenesis • positive regulation of cell population proliferation • protein transport • negative regulation of inflammatory response • calcium ion transport • GO:0072468 signal transduction • positive regulation of smooth muscle cell proliferation • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • calcitonin gene-related peptide receptor signaling pathway • adrenomedullin receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10203	n/a
Ensembl	ENSG00000064989	n/a
UniProt	Q16602	n/a
RefSeq (mRNA)	NM_001271751 NM_005795 NM_001369434 NM_001369435	n/a
RefSeq (protein)	NP_001258680 NP_005786 NP_001356363 NP_001356364	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALCRL yw CALCRL a elwir hefyd yn Calcitonin receptor like receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALCRL.

• CRLR
• CGRPR

Llyfryddiaeth

• "Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. ". Mol Vis. 2009. PMID 19898635.
• "Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteins. ". Biochem Biophys Res Commun. 2009. PMID 19394311.
• "The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach. ". J R Soc Interface. 2013. PMID 24047872.
• "The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling. ". Br J Pharmacol. 2012. PMID 22142144.
• "Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor.". Peptides. 2011. PMID 20946927.