BIN1

BIN1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MUZ, 1MV0, 1MV3, 2FIC, 2RMY, 2RND, 5I22
Dynodwyr
Cyfenwau	BIN1, AMPH2, AMPHL, SH3P9, bridging integrator 1, CNM2
Dynodwyr allanol	OMIM: 601248 HomoloGene: 113707 GeneCards: BIN1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• GO:0001948, GO:0016582 protein binding; • RNA polymerase binding; • identical protein binding; • tau protein binding; • actin filament binding; • protease binding; • phospholipid binding; • clathrin binding; • chaperone binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • I band; • T-tubule; • lipid tube; • node of Ranvier; • axon; • Z discdkac; • actin cytoskeleton; • axon initial segment; • cnewyllyn cell; • nuclear envelope; • cytosol; • endosome; • Cytosgerbwd; • Cellbilen; • synaptic vesicle; • sarcolemma; • synapse;
Prosesau biolegol	• regulation of endocytosis; • regulation of neuron differentiation; • cell differentiation; • endocytosis; • positive regulation of astrocyte differentiation; • multicellular organism development; • muscle cell differentiation; • positive regulation of apoptotic process; • lipid tube assembly; • cell population proliferation; • GO:0022415 viral process; • nucleus localization; • nucleus organization; • membrane organization; • cytoskeleton organization; • endosome to lysosome transport; • positive regulation of actin filament polymerization; • T-tubule organization; • regulation of heart rate by cardiac conduction; • negative regulation of potassium ion transmembrane transport; • negative regulation of amyloid-beta formation; • negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; • negative regulation of ventricular cardiac muscle cell action potential; • negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;
	Sources:Amigo / QuickGO
Orthologau
	274
	n/a
	ENSG00000136717
	n/a
	O00499
	n/a
NM_004305; NM_139343; NM_139344; NM_139345; NM_139346;
	NM_139347; NM_139348; NM_139349; NM_139350; NM_139351; NM_001320632; NM_001320633; NM_001320634; NM_001320640; NM_001320641; NM_001320642
	n/a
NP_001307561; NP_001307562; NP_001307563; NP_001307569; NP_001307570;
	NP_001307571; NP_004296; NP_647593; NP_647863; NP_647595; NP_647596; NP_647597; NP_647598; NP_647599; NP_647600; NP_647601; NP_647601.1; NP_001307561.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIN1 yw BIN1 a elwir hefyd yn Bridging integrator 1, isoform CRA_g , Bridging integrator 1, isoform CRA_j a Bridging integrator 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q14.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIN1.

CNM2
AMPH2
AMPHL
SH3P9

Llyfryddiaeth

"The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations. ". Clin Chim Acta. 2017. PMID 28302384.
"The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment. ". Mol Neurodegener. 2016. PMID 27538496.
"Subcellular Changes in Bridging Integrator 1 Protein Expression in the Cerebral Cortex During the Progression of Alzheimer Disease Pathology. ". J Neuropathol Exp Neurol. 2016. PMID 27346750.
"Potential contribution of the Alzheimer's disease risk locus BIN1 to episodic memory performance in cognitively normal Type 2 diabetes elderly. ". Eur Neuropsychopharmacol. 2016. PMID 26947052.
"The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease.". J Neurol. 2015. PMID 26233692.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BIN1 - Cronfa NCBI

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[2]