File:Patterns of p53 expression.png

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Patterns of p53 expression

Summary

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Description
English: Different patterns of p53 expression in endometrial cancers on chromogenic immunohistochemistry:
  • Wild-type, upper left: Endometrial endometrioid carcinoma showing normal wild-type pattern of p53 expression with variable proportion of tumor cell nuclei staining with variable intensity. Note, this wild-type pattern should not be reported as “positive,” because this is ambiguous reporting language.
  • Overexpression, upper right: Endometrial endometrioid carcinoma, grade 3, with overexpression, showing strong staining in virtually all tumor cell nuclei, much stronger compared with the internal control of fibroblasts in the center. Note, there is some cytoplasmic background indicating that this staining is quite strong but this should not be interpreted as abnormal cytoplasmic pattern.
  • Complete absence, lower left: Endometrial serous carcinoma showing complete absence of p53 expression with internal control showing moderate to strong but variable staining. Note, wild-type pattern in normal atrophic glands at 12 and 6 o’clock.
  • Both cytoplasmic and nuclear, lower right: Endometrial endometrioid carcinoma showing cytoplasmic p53 expression with internal control (stroma and normal endometrial glands) showing nuclear wild-type pattern. The cytoplasmic pattern is accompanied by nuclear staining of similar intensity.
Date
Source

Köbel M, Ronnett BM, Singh N, Soslow RA, Gilks CB, McCluggage WG (2019). "Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility.". Int J Gynecol Pathol 38 Suppl 1: S123-S131. DOI:10.1097/PGP.0000000000000488. PMID 29517499. PMC: 6127005.
- "This is an open access article distributed under the Creative Commons Attribution License 4.0"

Mikael Häggström, M.D.
Author Köbel M, Ronnett BM, Singh N, Soslow RA, Gilks CB, McCluggage WG, Häggström M
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Date/TimeThumbnailDimensionsUserComment
current20:51, 21 September 2022Thumbnail for version as of 20:51, 21 September 2022945 × 711 (1.36 MB)Mikael Häggström (talk | contribs)Uploaded a work by Köbel M, Ronnett BM, Singh N, Soslow RA, Gilks CB, McCluggage WG from {{cite journal| author=Köbel M, Ronnett BM, Singh N, Soslow RA, Gilks CB, McCluggage WG| title=Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility. | journal=Int J Gynecol Pathol | year= 2019 | volume= 38 Suppl 1 | issue= | pages= S123-S131 | pmid=29517499 | doi=10.1097/PGP.0000000000000488 | pmc=6127005 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/e...

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