Olav Zilian, MD, PhD, EMBA
Lausanne, Waadt, Schweiz
2661 Follower:innen
500 Kontakte
Info
06/2021 - present, Executive Director at Pictet Investment Office:
In my role as…
Aktivitäten
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Just launched. Check out the website. https://lnkd.in/d_4z_RX3
Just launched. Check out the website. https://lnkd.in/d_4z_RX3
Beliebt bei Olav Zilian, MD, PhD, EMBA
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I am pleased to inform that due to growing demand I have launched Basel Biotech Consulting GmbH. Feel free to get in contact for a non-binding…
I am pleased to inform that due to growing demand I have launched Basel Biotech Consulting GmbH. Feel free to get in contact for a non-binding…
Beliebt bei Olav Zilian, MD, PhD, EMBA
Berufserfahrung
Ausbildung
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Rochester-Bern Executive Programs
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Activities and Societies: CAS - Certificate of Advanced Studies in General Management. Rochester-Bern alumnus
Legal ground and obligations of BoD, best practice of corporate governance, risk management, strategy, finance and valuation, leadership, fair processes, innovation, change management, prevention and handling of crisis
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Activities and Societies: Training modules included expeditions to Mumbai/India, Chengdu/China and Silicon Valley/USA. Hands-on coaching of a start-up company developing a drug/nutraceutical for diabetes/overweight. IMD Alumnus
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Executive training in general business management
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–Heute
Pharma, biotech and medtech ventures
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–Heute
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Certificate as prerequiste to begin PhD thesis
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MD thesis in collaboration with Roche Diagnostics on an anti-HIV IGM test to identify people being in the early phase of HIV infection before traditional serological tests turn positive, i.e. before anti-HIV IgG would be detectable [test later succeeded by another, more direct test, i.e. based on PCR on HIV sequences]
Bescheinigungen und Zertifikate
Ehrenamt
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Vice President - Former Member of the Executive Board
NBIA Suisse - Philanthropic patient association, searching for therapeutics for NBIA patients
–Heute 9 Jahre 3 Monate
Health
NBIA Suisse: Oversight and sponsorship of a research project on potential therapeutics for MPAN, a NBIA-type of neurodegenerative disorders (NBIA: Neurodegeneration with Brain Iron Accumulation; MPAN: Mitochondrial membrane protein-associated neurodegeneration).
Contact of NBIA Suisse, President Fatemeh Mollet: [email protected]
Contact for further information, support and donations: [email protected] -
Trainer in summer and winter alpinism for members of the SAC Youth Organization
Swiss Alpine Club (SAC)
– 9 Jahre
Education
Veröffentlichungen
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The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells
J Cell Biol. 2015 Nov 23;211(4):845-62
The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains unclear. Here, by exploiting an ex vivo system, we show that at mitosis of purified mammary stem cells (SCs), Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the SC…
The cell fate determinant Numb orchestrates tissue morphogenesis and patterning in developmental systems. In the human mammary gland, Numb is a tumor suppressor and regulates p53 levels. However, whether this function is linked to its role in fate determination remains unclear. Here, by exploiting an ex vivo system, we show that at mitosis of purified mammary stem cells (SCs), Numb ensures the asymmetric outcome of self-renewing divisions by partitioning into the progeny that retains the SC identity, where it sustains high p53 activity. Numb also controls progenitor maturation. At this level, Numb loss associates with the epithelial-to-mesenchymal transition and results in differentiation defects and reacquisition of stemness features. The mammary gland of Numb-knockout mice displays an expansion of the SC compartment, associated with morphological alterations and tumorigenicity in orthotopic transplants. This is because of low p53 levels and can be inhibited by restoration of Numb levels or p53 activity, which results in successful SC-targeted treatment.
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Scope for innovation in immunotherapy from the financial market's point of view: Phacilitate Immunotherapy Leaders' Forum 2012.
Hum Vaccin Immunother. 2012 Oct;8(10):1370-2
In the vast area of immunotherapies, the development of monoclonal antibodies as a therapeutic concept emerged as a quantum leap out of the area of traditional vaccines (Köhler and Milstein) in vitro selection and optimisation made it possible to elaborate a single biological molecule from the molecular plethora of an individual adaptive immune response and to utilize such a cloned antibody repeatedly in a generalized fashion whenever the therapeutic indication is given to humans. At present…
In the vast area of immunotherapies, the development of monoclonal antibodies as a therapeutic concept emerged as a quantum leap out of the area of traditional vaccines (Köhler and Milstein) in vitro selection and optimisation made it possible to elaborate a single biological molecule from the molecular plethora of an individual adaptive immune response and to utilize such a cloned antibody repeatedly in a generalized fashion whenever the therapeutic indication is given to humans. At present, some 25 therapeutic monoclonal antibodies are currently being marketed in oncology, exceeding sales of USD20bn in 2011. A total of about 270 antibodies are currently in Phase II and III clinical development. Working on the assumption of usually lower attrition rates for antibody candidates, we expect approximately 120 of these 270 antibodies to be finally approved. This poses some key questions. What level of differentiation is required so that the coming new antibody drugs can command premium pricing when members of the founding generation become generic and inexpensive? What will global demand for antibody drugs be in view of the rising buying power in emerging pharmaceutical ('pharmerging') markets, but which is still not comparable with that of developed ones? What would the next quantum leaps be that might potentially push antibody technology on to a next level by disruptive innovation? Presentations given at the Phacilitate Immunotherapy Leaders' Forum 2012 (9-11 May in Barcelona) reflected on these questions and provided some stimulating perspectives.
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Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas
Cancer Res. 2010 Aug 15;70(16):6619-28
Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is required for Armadillo/beta-catenin signaling. Conditional ablation of Bcl9/Bcl9l in the intestinal epithelium, where the essential role of Wnt signaling in epithelial homeostasis and stem cell maintenance is well documented, resulted in…
Canonical Wnt signaling plays a critical role in stem cell maintenance in epithelial homeostasis and carcinogenesis. Here, we show that in the mouse this role is critically mediated by Bcl9/Bcl9l, the mammalian homologues of Legless, which in Drosophila is required for Armadillo/beta-catenin signaling. Conditional ablation of Bcl9/Bcl9l in the intestinal epithelium, where the essential role of Wnt signaling in epithelial homeostasis and stem cell maintenance is well documented, resulted in decreased expression of intestinal stem cell markers and impaired regeneration of ulcerated colon epithelium. Adenocarcinomas with aberrant Wnt signaling arose with similar incidence in wild-type and mutant mice. However, transcriptional profiles were vastly different: Whereas wild-type tumors displayed characteristics of epithelial-mesenchymal transition (EMT) and stem cell-like properties, these properties were largely abrogated in mutant tumors. These findings reveal an essential role for Bcl9/Bcl9l in regulating a subset of Wnt target genes involved in controlling EMT and stem cell-related features and suggest that targeting the Bcl9/Bcl9l arm of Wnt signaling in Wnt-activated cancers might attenuate these traits, which are associated with tumor invasion, metastasis, and resistance to therapy.
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Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike
J Immunol. 2007 Jun 1;178(11):6746-51
The mammalian ortholog of the conserved Drosophila adaptor protein Numb (Nb) and its homolog Numblike (Nbl) modulate neuronal cell fate determination at least in part by antagonizing Notch signaling. Because the Notch pathway has been implicated in regulating hemopoietic stem cell self-renewal and T cell fate specification in mammals, we investigated the role of Nb and Nbl in hemopoiesis using conditional gene targeting. Surprisingly simultaneous deletion of both Nb and Nbl in murine bone…
The mammalian ortholog of the conserved Drosophila adaptor protein Numb (Nb) and its homolog Numblike (Nbl) modulate neuronal cell fate determination at least in part by antagonizing Notch signaling. Because the Notch pathway has been implicated in regulating hemopoietic stem cell self-renewal and T cell fate specification in mammals, we investigated the role of Nb and Nbl in hemopoiesis using conditional gene targeting. Surprisingly simultaneous deletion of both Nb and Nbl in murine bone marrow precursors did not affect the ability of stem cells to self-renew or to give rise to differentiated myeloid or lymphoid progeny, even under competitive conditions in mixed chimeras. Furthermore, T cell fate specification and intrathymic T cell development were unaffected in the combined absence of Nb and Nbl. Collectively our data indicate that the Nb family of adaptor proteins is dispensable for hemopoiesis and lymphopoiesis in mice, despite their proposed role in neuronal stem cell development.
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Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense
PLoS Comput Biol. 2005 Nov;1(6):e63. Epub 2005 Nov 18
There are a variety of bacterial defense strategies to survive in a hostile environment. Generation of extracellular polysaccharides has proved to be a simple but effective strategy against the host's innate immune system. A comparative genomics approach led us to identify a new protein family termed Stealth, most likely involved in the synthesis of extracellular polysaccharides. This protein family is characterized by a series of domains conserved across phylogeny from bacteria to eukaryotes…
There are a variety of bacterial defense strategies to survive in a hostile environment. Generation of extracellular polysaccharides has proved to be a simple but effective strategy against the host's innate immune system. A comparative genomics approach led us to identify a new protein family termed Stealth, most likely involved in the synthesis of extracellular polysaccharides. This protein family is characterized by a series of domains conserved across phylogeny from bacteria to eukaryotes. In bacteria, Stealth (previously characterized as SacB, XcbA, or WefC) is encoded by subsets of strains mainly colonizing multicellular organisms, with evidence for a protective effect against the host innate immune defense. More specifically, integrating all the available information about Stealth proteins in bacteria, we propose that Stealth is a D-hexose-1-phosphoryl transferase involved in the synthesis of polysaccharides. In the animal kingdom, Stealth is strongly conserved across evolution from social amoebas to simple and complex multicellular organisms, such as Dictyostelium discoideum, hydra, and human. Based on the occurrence of Stealth in most Eukaryotes and a subset of Prokaryotes together with its potential role in extracellular polysaccharide synthesis, we propose that metazoan Stealth functions to regulate the innate immune system. Moreover, there is good reason to speculate that the acquisition and spread of Stealth could be responsible for future epidemic outbreaks of infectious diseases caused by a large variety of eubacterial pathogens. Our in silico identification of a homologous protein in the human host will help to elucidate the causes of Stealth-dependent virulence. At a more basic level, the characterization of the molecular and cellular function of Stealth proteins may shed light on fundamental mechanisms of innate immune defense against microbial invasion.
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Murine numb regulates granule cell maturation in the cerebellum
Dev Biol. 2004 Feb 1;266(1):161-77
Notch is a key regulator of vertebrate neurogenesis and the cytoplasmic adaptor protein Numb is a modulator of the Notch signaling pathway. To address the role of murine Numb in development of the central nervous system, we used a conditional gene ablation approach. We show that Numb is involved in the maturation of cerebellar granule cells. Although the specification of neural cell fates in the cerebellum is not affected in the absence of Numb, the transition from a mitotic progenitor to a…
Notch is a key regulator of vertebrate neurogenesis and the cytoplasmic adaptor protein Numb is a modulator of the Notch signaling pathway. To address the role of murine Numb in development of the central nervous system, we used a conditional gene ablation approach. We show that Numb is involved in the maturation of cerebellar granule cells. Although the specification of neural cell fates in the cerebellum is not affected in the absence of Numb, the transition from a mitotic progenitor to a mature granule cell is aberrant and migration of postmitotic granule cells to the internal granule cell layer is delayed. In some animals, this results in a complete agenesis of granule cells and a strong ataxia. We confirmed these findings in vitro and found that Numb-deficient cerebellar progenitor cells show a marked delay in granule cell maturation. Our results suggest that Numb plays a role in the transition of a mitotic progenitor to a fully differentiated granule cell in the cerebellum. In addition, the maturation of Purkinje cells is also delayed in Numb-deficient mice.
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Multiple roles of mouse Numb in tuning developmental cell fates
Curr Biol. 2001 Apr 3;11(7):494-501
BACKGROUND:
Notch signaling regulates multiple differentiation processes and cell fate decisions during both invertebrate and vertebrate development. Numb encodes an intracellular protein that was shown in Drosophila to antagonize Notch signaling at binary cell fate decisions of certain cell lineages. Although overexpression experiments suggested that Numb might also antagonize some Notch activity in vertebrates, the developmental processes in which Numb is involved remained…BACKGROUND:
Notch signaling regulates multiple differentiation processes and cell fate decisions during both invertebrate and vertebrate development. Numb encodes an intracellular protein that was shown in Drosophila to antagonize Notch signaling at binary cell fate decisions of certain cell lineages. Although overexpression experiments suggested that Numb might also antagonize some Notch activity in vertebrates, the developmental processes in which Numb is involved remained elusive.
RESULTS:
We generated mice with a homozygous inactivation of Numb. These mice died before embryonic day E11.5, probably because of defects in angiogenic remodeling and placental dysfunction. Mutant embryos had an open anterior neural tube and impaired neuronal differentiation within the developing cranial central nervous system (CNS). In the developing spinal cord, the number of differentiated motoneurons was reduced. Within the peripheral nervous system (PNS), ganglia of cranial sensory neurons were formed. Trunk neural crest cells migrated and differentiated into sympathetic neurons. In contrast, a selective differentiation anomaly was observed in dorsal root ganglia, where neural crest--derived progenitor cells had migrated normally to form ganglionic structures, but failed to differentiate into sensory neurons.
CONCLUSIONS:
Mouse Numb is involved in multiple developmental processes and required for cell fate tuning in a variety of lineages. In the nervous system, Numb is required for the generation of a large subset of neuronal lineages. The restricted requirement of Numb during neural development in the mouse suggests that in some neuronal lineages, Notch signaling may be regulated independently of Numb. -
double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs
Development. 1999 Dec;126(23):5409-20
We have isolated the discs overgrown gene of Drosophila and shown that it encodes a homolog of the Casein kinase I(delta)/(epsilon) subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs…
We have isolated the discs overgrown gene of Drosophila and shown that it encodes a homolog of the Casein kinase I(delta)/(epsilon) subfamily and is identical to the double-time gene. However, in contrast to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs overgrown protein is a crucial component in the mechanism that links cell survival during proliferation to growth arrest in imaginal discs. This work provides the first analysis in a multicellular organism of Casein kinase I(delta)/(epsilon) functions necessary for survival. Since the amino acid sequences and three-dimensional structures of Casein kinase I(delta)/(epsilon) enzymes are highly conserved, the results suggest that these proteins may also function in controlling cell growth and survival in other organisms.
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Embryonic expression and characterization of a Ptx1 homolog in Drosophila
Mech Dev. 1997 Nov;68(1-2):139-47
We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the third alpha-helix of the homeodomain. D-Ptx1 is expressed at various restricted locations throughout embryogenesis. Initial expression of D-Ptx1 in the posterior-most region of the blastoderm embryo is controlled by fork head activity in response to the…
We describe the molecular characterization of the paired-type homeobox gene D-Ptx1 of Drosophila, a close homolog of the mouse pituitary homeobox gene Ptx1 and the unc-30 gene of C. elegans, characterized by a lysine residue at position 9 of the third alpha-helix of the homeodomain. D-Ptx1 is expressed at various restricted locations throughout embryogenesis. Initial expression of D-Ptx1 in the posterior-most region of the blastoderm embryo is controlled by fork head activity in response to the activated Ras/Raf signaling pathway. During later stages of embryonic development. D-Ptx1 transcripts and protein accumulate in the posterior portion of the midgut, in the developing Malpighian tubules, in a subset of ventral somatic muscles, and in neural cells. Phenotypic analysis of gain-of-function and lack-of-function mutant embryos show that the D-Ptx1 gene is not involved in morphologically apparent differentiation processes. We conclude that D-Ptx1 is more likely to control physiological cell functions than pattern formation during Drosophila embryogenesis
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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
Genes Dev. 1995 Mar 1;9(5):534-46
Homozygous loss of the warts (wts) gene of Drosophila, caused by mitotic recombination in somatic cells, leads to the formation of cell clones that are fragmented, rounded, and greatly overgrown compared with normal controls. Therefore, the gene is required for the control of the amount and direction of cell proliferation as well as for normal morphogenesis. The absence of wts function also results in apical hypertrophy of imaginal disc epithelial cells. Secretion of cuticle over and between…
Homozygous loss of the warts (wts) gene of Drosophila, caused by mitotic recombination in somatic cells, leads to the formation of cell clones that are fragmented, rounded, and greatly overgrown compared with normal controls. Therefore, the gene is required for the control of the amount and direction of cell proliferation as well as for normal morphogenesis. The absence of wts function also results in apical hypertrophy of imaginal disc epithelial cells. Secretion of cuticle over and between the domed apical surfaces of these cells leads to a honeycomb-like structure and gives the superficial wart-like phenotype of mitotic clones on the adult. One wts allele allows survival of homozygotes to the late larval stage, and these larvae show extensive imaginal disc overgrowth. Because of the excess growth and abnormalities of differentiation that follow homozygous loss, we consider wts to be a tumor suppressor gene. The wts gene is defined by the breakpoints of overlapping deficiencies in the right telomeric region of chromosome 3, region 100A, and by lethal P-element insertions and excisions. It encodes a protein kinase that is most similar to human myotonic dystrophy kinase, the Neurospora cot-1 protein kinase, two cell-cycle regulated kinases of yeast, and several putative kinases from plants. These proteins define a new subfamily of protein kinases that are closely related to but distinct from the cyclic AMP-dependent kinases. Although myotonic dystrophy is defined by a neuromuscular disorder, it is sometimes associated with multiple pilomatrixomas, which are otherwise rare epithelial tumors, and with other tumors including neurofibromas and parathyroid adenomas. Our results raise the possibility that homozygous loss of the myotonic dystrophy kinase may contribute to the development of these tumors.
Patente
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Conditional Gene Expression in Xenografts
CH Withdrawn
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Stem Cell Expansion in Genetically Modified Tissues
CH Withdrawn
Auszeichnungen/Preise
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Europe No.1 Stock Picker in Biotechnology
StarMine
StarMine Analyst Award based on performance
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Best Swiss equity sell-side analyst
AQ Research
Selected best Swiss equity sell-side analyst based on performance evaluated by AQ Research
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Helvea best brokerage firm in biotech
Thomson Extel
Helvea voted best brokerage firm in biotech in Thomson Extel’s pan-EU survey of companies
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Best Swiss equity sell-side analyst
Thomson Extel
Voted best Swiss equity sell-side analyst in Thomson Extel’s pan-European survey of investors
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Best Swiss equity sell-side analyst
AQ Research
Selected best Swiss equity sell-side analyst based on performance evaluated by AQ Research
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Research Grant by Swiss Cancer League
Swiss Cancer League
Research Grant by Swiss Cancer League – Analysis of Stealth, a Notch-related protein
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Var. PhD training grants for MD at Biocenter Basel
Various foundations
Various training grants for PhD-related post-MD education at Biocenter Basel
Sprachen
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German
Muttersprache oder zweisprachig
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English
Verhandlungssicher
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French
Fließend
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Italian
Grundkenntnisse
Organisationen
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SAC, Swiss Alpine Club
Member
–Heute
Weitere Aktivitäten von Olav Zilian, MD, PhD, EMBA
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What a journey! October 1st marks two important milestones in my career journey. It is the 20th anniversary of my joining Novartis, and it is also…
What a journey! October 1st marks two important milestones in my career journey. It is the 20th anniversary of my joining Novartis, and it is also…
Beliebt bei Olav Zilian, MD, PhD, EMBA
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𝗕𝗲𝘆𝗼𝗻𝗱 𝗖𝗵𝗼𝗰𝗼𝗹𝗮𝘁𝗲, 𝗣𝗶𝗹𝗹𝘀, 𝗮𝗻𝗱 𝗕𝗮𝗻𝗸𝗶𝗻𝗴: 𝗥𝗲𝗯𝗼𝗼𝘁𝗶𝗻𝗴 𝗦𝘄𝗶𝘁𝘇𝗲𝗿𝗹𝗮𝗻𝗱 𝘄𝗶𝘁𝗵 𝗗𝗲𝗲𝗽𝗧𝗲𝗰𝗵 Title of a…
𝗕𝗲𝘆𝗼𝗻𝗱 𝗖𝗵𝗼𝗰𝗼𝗹𝗮𝘁𝗲, 𝗣𝗶𝗹𝗹𝘀, 𝗮𝗻𝗱 𝗕𝗮𝗻𝗸𝗶𝗻𝗴: 𝗥𝗲𝗯𝗼𝗼𝘁𝗶𝗻𝗴 𝗦𝘄𝗶𝘁𝘇𝗲𝗿𝗹𝗮𝗻𝗱 𝘄𝗶𝘁𝗵 𝗗𝗲𝗲𝗽𝗧𝗲𝗰𝗵 Title of a…
Beliebt bei Olav Zilian, MD, PhD, EMBA
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Sachs Life Sciences and Biotechnology Forum - Global Foresights and Trends China Sachs Associates - September 25-26, Basel Chinese Science &…
Sachs Life Sciences and Biotechnology Forum - Global Foresights and Trends China Sachs Associates - September 25-26, Basel Chinese Science &…
Beliebt bei Olav Zilian, MD, PhD, EMBA
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𝐅𝐫𝐨𝐦 𝐊𝐧𝐨𝐜𝐤𝐨𝐮𝐭 𝐭𝐨 𝐂𝐨𝐦𝐞𝐛𝐚𝐜𝐤: 𝐇𝐨𝐰 Boston Scientific 𝐏𝐮𝐥𝐥𝐞𝐝 𝐚 𝐑𝐨𝐜𝐤𝐲! 𝐓𝐡𝐞 𝐊𝐧𝐨𝐜𝐤𝐨𝐮𝐭 𝐏𝐮𝐧𝐜𝐡 In Jan…
𝐅𝐫𝐨𝐦 𝐊𝐧𝐨𝐜𝐤𝐨𝐮𝐭 𝐭𝐨 𝐂𝐨𝐦𝐞𝐛𝐚𝐜𝐤: 𝐇𝐨𝐰 Boston Scientific 𝐏𝐮𝐥𝐥𝐞𝐝 𝐚 𝐑𝐨𝐜𝐤𝐲! 𝐓𝐡𝐞 𝐊𝐧𝐨𝐜𝐤𝐨𝐮𝐭 𝐏𝐮𝐧𝐜𝐡 In Jan…
Beliebt bei Olav Zilian, MD, PhD, EMBA
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For this first Publication Spotlight, we come back to a recent tour de force study on spatial 3D #multiomics data integration and analysis led by Dr…
For this first Publication Spotlight, we come back to a recent tour de force study on spatial 3D #multiomics data integration and analysis led by Dr…
Beliebt bei Olav Zilian, MD, PhD, EMBA