Ari Massoudi
Neuenburg, Neuenburg, Schweiz
18.071 Follower:innen
500 Kontakte
Neuenburg, Neuenburg, Schweiz
18.071 Follower:innen
500 Kontakte
Info
To solve our Global challenges and insure us a brilliant future, I believe we have to…
Artikel von Ari Massoudi
Beiträge
Aktivitäten
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Storytime : une conversation que j'ai eu avec une fondatrice. Cette femme dirige une startup dans la tech et elle se fait solliciter par un collège…
Storytime : une conversation que j'ai eu avec une fondatrice. Cette femme dirige une startup dans la tech et elle se fait solliciter par un collège…
Veröffentlicht von Ari Massoudi
Berufserfahrung
Ausbildung
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Université Côte d'Azur
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Specialization : Stem Cells – Cell therapy
Elucidation of the mechanism by which Stem Cells derived from human fat contribute to muscle formation -
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Specialization : Somatic Transgenesis – Gene therapy
Screening of genetically-modified virus to express efficiently proteins of interest in human muscles -
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This training sets out to give those who hold a PhD in Hard Science (Formal, Natural and Engineering Sciences), the managerial competencies and other skills required by innovative companies and technology transfer organizations, in the corporate, market and project management areas.
The fields studied during this training:
- Economics, Finance, Management and Marketing of innovation processes
- Knowledge Management, Industrial Property, Technology Scouting and Forecasting
-…This training sets out to give those who hold a PhD in Hard Science (Formal, Natural and Engineering Sciences), the managerial competencies and other skills required by innovative companies and technology transfer organizations, in the corporate, market and project management areas.
The fields studied during this training:
- Economics, Finance, Management and Marketing of innovation processes
- Knowledge Management, Industrial Property, Technology Scouting and Forecasting
- Business Model and Value-Proposition Design, TRIZ, Design Thinking
Veröffentlichungen
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Biologie Des Cellules Souches Humaines
Editions Universitaires Europeennes
Les cellules souches et la thérapie cellulaire génèrent un engouement certain aussi bien pour les biologistes que pour les cliniciens et le grand public. La recherche fondamentale en biologie du développement, en utilisant les cellules souches comme modèle d'étude permet d'aborder les régulations et mécanismes tant cellulaires que moléculaire impliquées au cours de l'embryogenèse, de l'histogenèse foetale et de l'histogenèse adulte au cours du renouvellement tissulaire normal ou après une…
Les cellules souches et la thérapie cellulaire génèrent un engouement certain aussi bien pour les biologistes que pour les cliniciens et le grand public. La recherche fondamentale en biologie du développement, en utilisant les cellules souches comme modèle d'étude permet d'aborder les régulations et mécanismes tant cellulaires que moléculaire impliquées au cours de l'embryogenèse, de l'histogenèse foetale et de l'histogenèse adulte au cours du renouvellement tissulaire normal ou après une nécrose tissulaire. Le nombre de laboratoires s'intéressant à l'étude des cellules souches ne cesse de croître, il y a d'ores et déjà une répercutions sur l'enseignement supérieure et la formation au niveau des filières des sciences de le vie et de la santé. Ce présent manuel présentera les cellules souches et leurs applications actuelles et futures en thérapie chez l'Homme. L'ensemble des connaissances, définitions, concepts et théories autour de ces cellules, parfois fortement en contradiction sur la scène de la recherche sera également abordé et discuté.
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Human adipose tissue-derived multipotent stem cells differentiate in vitro and in vivo into osteocyte-like cells
Biochemical and Biophysical Research Communications
Cell-based therapies are used to treat bone defects. We recently described that human multipotent adipose-derived stem (hMADS) cells, which exhibit a normal karyotype, self renewal, and the maintenance of their differentiation properties, are able to differentiate into different lineages. Herein, we show that hMADS cells can differentiate into osteocyte-like cells. In the presence of a low amount of serum and EGF, hMADS cells express specific molecular markers, among which alkaline phosphatase,…
Cell-based therapies are used to treat bone defects. We recently described that human multipotent adipose-derived stem (hMADS) cells, which exhibit a normal karyotype, self renewal, and the maintenance of their differentiation properties, are able to differentiate into different lineages. Herein, we show that hMADS cells can differentiate into osteocyte-like cells. In the presence of a low amount of serum and EGF, hMADS cells express specific molecular markers, among which alkaline phosphatase, CBFA-1, osteocalcin, DMP1, PHEX, and podoplanin and develop functional gap-junctions. When loaded on a hardening injectable bone substitute (HIBS) biomaterial and injected subcutaneously into nude mice, hMADS cells develop mineralized woven bone 4 weeks after implantation. Thus hMADS cells represent a valuable tool for pharmacological and biological studies of osteoblast differentiation in vitro and bone development in vivo.
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Human adipose tissue-derived mesenchymal stem cells acquire muscle identity only after spontaneous fusion with myoblasts
HAL
Mesenchymal stem cells have an intrinsic capacity to differentiate into various cell types in culture or after transplantation. Previously we have shown that multipotent stem cells derived from human adipose tissue (hMADS cells) were able to restore dystrophin expression after transplantation in mdx mice. In the current study, we investigated the mechanism of skeletal muscle phenotype acquisition by hMADS cells. We first tested various culture conditions to induce an intrinsic myogenic program…
Mesenchymal stem cells have an intrinsic capacity to differentiate into various cell types in culture or after transplantation. Previously we have shown that multipotent stem cells derived from human adipose tissue (hMADS cells) were able to restore dystrophin expression after transplantation in mdx mice. In the current study, we investigated the mechanism of skeletal muscle phenotype acquisition by hMADS cells. We first tested various culture conditions to induce an intrinsic myogenic program in hMADS cells. Neither myotube formation nor Pax7, myf-5, MyoD and myogenin expression could be detected under these conditions. In contrast, when co-cultured with myoblasts, hMADS cells reproducibly contributed to hybrid myotube formation, expressed several muscle differentiation markers and had the ability to restore dystrophin expression in human dystrophic background. Interestingly, this myogenic conversion was not associated with the expression of key transcription factors for muscle determination/differentiation. Therefore, our results clearly demonstrated that acquisition of myogenic identity by hMADS cells did not occur via a bona fide determination/differentiation process. We propose a model of myogenic conversion of human mesenchymal stem cells derived from adipose tissue in which, only after fusion, transcription factors of myoblasts were able to program hMADS genome toward the skeletal muscle lineage.
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English
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French
Muttersprache oder zweisprachig
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Persian
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