InSphero

3D Cell Culture Essentials, summarized by Darwin Microfluidics! Well said, Lise Voland 👏 🧐 Have you faced challenges when transitioning from 2D to 3D Cell Culture? Share your experience in the comments 👇 Jan Lichtenberg Frauke Greve Lisa Hoelting Olivier Frey Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD Paul Edgard Clémençon

🧐 WHAT! Tissue loss?? 🧐 😉 Of course, preventing tissue loss is not a fun and certainly not an easy task (contrary to filming this video)! That’s why we developed our Akura™ Plates with a special feature to make your life much easier:  The SureXchange well design enables optimal protection of the spheroids in a cavity at the bottom of the well during liquid exchange. 💪 Want to pipette like a pro? Our Senior Product Manager, Dr. Frauke Greve, asked our 3D in vitro experts about their tips and tricks on how to prevent tissue loss in Akura™ Spheroid Microplates. 👉 Read their insights via the link in comments Olivier Frey Lisa Hoelting Tamara Häfeli Karolina Kaczmarska Felix Forschler Ben Kodiyan Hajnalka Varga Tala Issa Tina Žel Rositsa Hadzhipetrova Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD #akuraplates #TheModelOfExcellence™ #pipetting #spheroids #organoids #microtissues

⭐️ Spotlight Series – HUMAIN Award Winners ⭐️ 🎥 In this fireside chat series we give the stage to the five winners of the HUMAIN Award – a joint initiative of InSphero and the Physicians Committee for Responsible Medicine for enabling and supporting researchers advancing non-animal drug discovery. Meet Dr. Burak Toprakhisar from the Vrije Universiteit Brussel, with whom we discussed his project, titled “Revealing the early cellular events in human liver inflammation by using HiPSC ”. ▶️ Watch the interview to learn: ✔️ What inspired Burak’s research on MASLD ✔️ How non-animal methods, such as human liver microtissues enable recreating the human liver microenvironment in vitro for reliable decision-making ✔️ How will InSphero’s assay-ready 3D InSight™Human Liver Microtissues and Akura™Twin #OoC platform will enable characterizing the #crosstalk between the liver spheroids and immune cells 🔜 Stay tuned for our next interview with Dr. Astrid Hofman from the University of Zurich 👉 Learn more about our reliable and scalable solutions for Liver Disease via the link in the comments. Are you planning your next study on #MASH? Learn more about our MASH CALL Initiative and join by September 6! Jan Lichtenberg Elizabeth Baker Janine McCarthy Lisa Hoelting Madhu Lal Nag, MBS PhD Olivier Frey Frauke Greve Francisco Verdeguer Radina Kostadinova, PhD Jesus Francisco Glaus Garzon Joel Zvick Rositsa Hadzhipetrova Tina Žel Wolfgang Moritz Paul Edgard Clémençon Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD #TheModelofExcellence™ #NAMs #3dinvitro #drugdiscovery #researchgrant #partnership #academia #liverdisease #mash #masld

🎶 It's summertime and the livin' is easy... 🎶 but fresh insights go with any weather, right? #TBT to Hamilton Bonaduz AG case study titled: “Enhancing Scalability and Quality of 3D In Vitro Cell Models Production through Automation” 🔔 This insightful resource describes the automated production and maintenance of spheroids via self-aggregation using our proprietary Akura™ microplate technology and Hamilton’s Microlab® STARlet. 👀 Read the Case Study and learn more about the: ✔️ Advantages of 3D in vitro cell models for drug discovery ✔️ Automation of the production of 3D in vitro cell models with the scalable Akura™ technology ✔️ Benefits of combining Akura™ technology and Hamilton’s pipetting technologies 👉 Link in comments Frauke Greve Gabriela Boza-Moran Carolina Elejalde Palmett Patrick Pfenninger Olivier Frey Lisa Hoelting Tamara Häfeli Agnieszka Pawlowska Ozlem Yavas Grining Judi Wardwell-Swanson Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD Tina Žel Rositsa Hadzhipetrova #3dinvitromodels #liquidhandling #automation #scalability #drugdiscovery #TheModelofExcellence™

🚀 Let's Go In Vitro for AI Drug Discovery 🚀   ⌨️“I’ve always been passionate about the benefits of #scalable 3D in vitro models. With #AI continuing to be incorporated into #drugdiscovery, I want to highlight how these models are indispensable building blocks”, remarked Dr. Jan Lichtenberg in his latest opinion piece for The Medicine Maker 👉 Read the full article, where our CEO and Co-founder highlights the crucial prerequisites of 3D in vitro models for AI-powered Drug Discovery https://lnkd.in/dxknjS4d 👀 We are curious to know your opinion: What is the future of 3D in vitro solutions in AI Drug Development? 👇Share your thoughts in the comments Jan Lichtenberg Paul Edgard Clémençon Madhu Lal Nag, MBS PhD Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD Wolfgang Moritz Bruno Filippi Burcak Yesildag Francisco Verdeguer Laure-Anne Ligeon Olivier Frey David Fluri Marion Bavand Stina Näslund Dr. Henriette Schneider Filip Henzler Rositsa Hadzhipetrova Tina Žel Karen Michailo #AI #Machinelearning #drugdiscovery #nonanimalmethods #NAMs #3dinvitromodels #drugdevelopment

Many researchers face problems with the reliability of 2D models and immune cell migration... These problems slow progress and lead to inconsistent data 🫤 To solve them, we're happy to share the Akura™ Twin microplate from InSphero with you! 🎉 This tool promotes robust handling and reliable culturing. The 384 conical well design aids high-throughput spheroid coculture and reduces losses! https://lnkd.in/eJNYnRyK You can now run up to 192 conditions with interconnected wells, enabling active crosstalk between tissues and immune cell migration 🦠 👩🔬👨🔬 #3Dcell #spheroids #microfluidics PS: It's even in the ANSI/SLAS standard format for quick implementation and automation 😉

📢 The MASH CALL Initiative – back by popular demand this 📆 September We at InSphero believe that there is a way to 🛑 #stopMASH, by joining forces with researchers and looking into new ways to investigate this unmet clinical need. After the successful first MASH CALL Initiative, we are launching a second round this 📆 September: 👩🔬 Is your research related to the complex, multi-faceted #liverdisease? ⭐️ Would you like to be at the forefront of finding an effective therapy, which will help over 115 million individuals worldwide? Within the MASH CALL Initiative, you will get valuable insights about the effects of your compounds related to: ✔️ anti-steatosis ✔️ anti-fibrosis ✔️ safety profile ✔️ comparison to clinical candidates 👉 Want to learn more? Click on the link in the comments and read the latest blog post by Dr. Francisco Verdeguer, VP of Liver Disease, who sheds light on the learnings from the first initiative and shares insights on the approach of the MASH CALL work-frame.   Francisco Verdeguer Radina Kostadinova, PhD Jesus Francisco Glaus Garzon Angelina Freitag Joel Zvick Philip Vonschallen Paul Edgard Clémençon Arumugham (Ragoo) Raghunathan Bärbel Ulmer Christine Schwenk Sue Grepper, PhD Madhu Lal Nag, MBS PhD Jan Lichtenberg Rositsa Hadzhipetrova Tina Žel PharmaNest Mathieu Petitjean #mashcallinitiative #liverdisease #mash #masld #3dcellculture #3dhumanliver #mashscreening

⭐️ Exciting day for InSpheros ⭐️ 🙏 We were honored to host our Scientific Advisory Board member, Prof. Matthias von Herrath, VP Chief Medical Office at Novo Nordisk and Director of the Diabetes Research Institute University of Miami, at our office yesterday!   Hearing about the complexities and challenges of battling #T1D reaffirms our dedication to supporting global efforts for a cure. ❗️Imagine making over 120 decisions daily to maintain balanced blood glucose levels - an insight highlighting the immense mental stress and potential for permanent damage from any missteps. 👋Stay tuned for more insights from Matthias, who discussed the recent advancements in T1D therapeutics with our VP of Islet Biology, Dr. Burcak Yesildag, and our CEO, Dr. Jan Lichtenberg.   🌍 Committed to the Fight Against T1D 🌍 At #InSphero our Islet Biology team, led by Burcak, is at the forefront of #Diabetes research, developing biologically #relevant, #scalable, and #reproducible 3D in vitro islet models. Our work aims to deepen our understanding of T1D, discover new therapies, and ultimately, transform lives by alleviating the burden of this challenging disease. Find out more via the link in comments 👇 Paul Edgard Clémençon, Arumugham (Ragoo) Raghunathan Bärbel Ulmer, Christine Schwenk, Sue Grepper, PhD Alexandra Title Chantal Rufer Sayro Jawurek Ben Kodiyan Lynn Scherpe Tina Žel Rositsa Hadzhipetrova #InSphero #T1DResearch #CureT1D #3Dcellculture #organonchip  

Heading to the #ISSCR2024 Annual Meeting in #Hamburg, Germany this week! I’m thrilled to be back in my former home city and excited to connect with fellow stem cell enthusiasts. I look forward to exploring the latest innovations. Let me know if you’ll be attending too! #InSphero #3DcellCulture #DiseaseModels #Spheroids #Organoids

⭐️ Spotlight Series – HUMAIN Award Winners ⭐️ 🎥 In this fireside chat series we give the stage to the five winners of the HUMAIN Award – a joint initiative of InSphero and the Physicians Committee for Responsible Medicine for enabling and supporting researchers advancing non-animal drug discovery. Meet Dr. Felicia Gerst from the University of Tuebingen, with whom we discussed her project, titled “Impact of pancreatic adipose tissue on islet function”. ▶️ Watch the interview to learn: ✔️ What inspired Felicia’s research on the pancreatic adipocytes ✔️ How non-animal methods, such as primary human islets will advance her studies Islet Biology ✔️ How will InSphero’s assay-ready 3D InSight™ Human Islet Microtissues and Akura™ Twin #OoC platform will enable characterizing the #crosstalk between the pancreatic adipocytes and pancreatic beta cells 🔜 Stay tuned for our next interview with Dr. Burak Toprakhisar from Vrije Universiteit Brussel 💡Learn more about our reliable and scalable solutions for Islet Biology via the link in the comments 👇 Jan Lichtenberg Elizabeth Baker Janine McCarthy Lisa Hoelting Madhu Lal Nag, MBS PhD Olivier Frey Frauke Greve Rositsa Hadzhipetrova Tina Žel Wolfgang Moritz Paul Edgard Clémençon Burcak Yesildag Alexandra Title Sayro Jawurek Chantal Rufer Ben Kodiyan Lynn Scherpe #TheModelofExcellence™ #NAMs #3dinvitro #drugdiscovery #researchgrant #partnership #academia #islets #diabetes #pancreaticfunction