3Brain AG

Are you also at SFN 2024? Don’t forget to stop by our booth / attend our talk to learn how our 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ integrated HD-MEAs can enhance your research. From compound screening to neuronal network analysis, discover how our technology is making an impact across neuroscience. 𝗔𝗻𝗱 𝗱𝗼𝗻'𝘁 𝗺𝗶𝘀𝘀 𝘁𝗵𝗲 𝗯𝗶𝗴 𝗿𝗲𝘃𝗲𝗮𝗹! We'll be launching our brand-new 𝟮𝟰-𝘄𝗲𝗹𝗹 𝗛𝗗-𝗠𝗘𝗔 𝘀𝘆𝘀𝘁𝗲𝗺, offering the highest number of simultaneously recording wells and electrodes available. 𝗠𝗲𝗲𝘁 𝘂𝘀:  𝗕𝗼𝗼𝘁𝗵: # 478 𝗧𝗮𝗹𝗸: "CorePlate™ : Revolutionizing organoid analysis", On Sun 6th Oct, 1:00pm CDT, Product Theater 2, 1500 Aisle (Exhibit Hall) #SFN2024

𝗔𝘁 𝗦𝗳𝗡 𝟮𝟬𝟮𝟰? 𝗗𝗼𝗻'𝘁 𝗺𝗶𝘀𝘀 𝗼𝘂𝘁 𝗼𝗻 𝘁𝗵𝗲 𝗲𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝘁𝗮𝗹𝗸𝘀 & 𝗽𝗼𝘀𝘁𝗲𝗿𝘀 𝘄𝗶𝘁𝗵 𝗼𝘂𝗿 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆!  Find out how STEMCELL is advancing disease modelling in the neural organoid field, and how CorePlate™ is contributing to this progress. You can attend their talk "𝗨𝘀𝗶𝗻𝗴 𝗛𝘂𝗺𝗮𝗻 𝗦𝘁𝗲𝗺 𝗖𝗲𝗹𝗹-𝗗𝗲𝗿𝗶𝘃𝗲𝗱 𝗡𝗲𝘂𝗿𝗮𝗹 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗳𝗼𝗿 𝗠𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗗𝗶𝘀𝗲𝗮𝘀𝗲" on 𝗢𝗰𝘁. 𝟴, 𝟮𝟬𝟮𝟰, 𝟭:𝟬𝟬 𝗣𝗠 - 𝟭:𝟯𝟬 𝗣𝗠 in 𝗠𝗖𝗣 𝗘𝘅𝗵𝗶𝗯𝗶𝘁 𝗛𝗮𝗹𝗹 𝗔𝗶𝘀𝗹𝗲 𝟵𝟬𝟬. Check out also their poster titled "𝗠𝗲𝗮𝘀𝘂𝗿𝗶𝗻𝗴 𝗮𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗶𝗻 𝗵𝘂𝗺𝗮𝗻 𝗽𝗹𝘂𝗿𝗶𝗽𝗼𝘁𝗲𝗻𝘁 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹-𝗱𝗲𝗿𝗶𝘃𝗲𝗱 𝗻𝗲𝘂𝗿𝗮𝗹 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗳𝗼𝗿 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝗺𝗼𝗱𝗲𝗹𝗶𝗻𝗴 𝗮𝗻𝗱 𝗱𝗿𝘂𝗴 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘆" on 𝗢𝗰𝘁 𝟲𝘁𝗵 between 𝟴:𝟬𝟬𝗮𝗺 – 𝟭𝟮:𝟬𝟬𝗣𝗠 in 𝗠𝗖𝗣 𝗛𝗮𝗹𝗹 𝗔 (𝗣𝗦𝗧𝗥𝟬𝟲𝟰.𝟬𝟮 / 𝗖𝟰𝟯).  Neural organoids have become a vital tool for modelling development and disease, however, variability in protocol methodologies can create diversity in structural and functional properties. To address this, STEMCELL Technologies and a:head bio AG developed standardized workflows for the generation, and long-term culture of cerebral and spinal cord organoids. To characterize their cerebral organoids a:head Bio and STEMCELL utilized 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟯𝗗 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 and a 𝗕𝗶𝗼𝗖𝗔𝗠 𝗗𝘂𝗽𝗹𝗲𝘅 where they acutely measured electrophysiological activity. They applied 4-aminopyridine (4-AP) to induce an epileptic phenotype, resulting in a 10-15 fold increase in mean Local Field Potential rate, and subsequently treated the organoids with Valproic acid resulting in a 3-5 fold reduction when treated with valproic acid. This approach holds great promise for creating consistency in organoid production, ultimately advancing disease modelling and drug discovery! Visit STEMCELL's talk and poster sessions to learn more, and stop by our booth (478) for a deeper dive into the future of disease modelling. See you there! #SfN2024 #CorePlate #OrganoidResearch

Collaboration is key! Collaboration truly is the key to unlocking scientific progress, and we couldn’t agree more with Axol Bioscience Ltd.! Sticking by this principle, we’ve been working together with Axol Bioscience Ltd. to demonstrate using iPSC-derived cells on CorePlate™ HD-MEAs, and the results are impressive! Check out the remarkable activity Axol Bioscience Ltd. recently recorded with a BioCAM DupleX & CorePlate™ from their hiPSC-derived Ventricular Cardiomyocytes after just 7 days in culture! This partnership is already making great strides, and we’re excited to share more research in the near future! 

We know that in research, every detail matters. That is why we have poured years of expertise into ensuring that our 24-well HD-MEA, 𝗛𝘆𝗽𝗲𝗿𝗖𝗔𝗠 𝗗𝗲𝗹𝘁𝗮 meets the highest standards of quality and precision—so you can focus on what really matters: 𝗮𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵.   Come meet us at #SfN to find out more! • 𝗕𝗼𝗼𝘁𝗵: #478   • 𝗧𝗮𝗹𝗸: "CorePlate™ : Revolutionizing organoid analysis", On Sun 6th Oct, 1:00pm CDT, Product Theater 2, 1500 Aisle (Exhibit Hall)  • 𝗦𝗽𝗲𝗮𝗸𝗲𝗿𝘀: Alessandro Maccione & Mauro Gandolfo 🔗 Find out more: https://lnkd.in/daJ-fhD7

𝗘𝘅𝗰𝗶𝘁𝗶𝗻𝗴 𝗻𝗲𝘄𝘀 𝗳𝗿𝗼𝗺 𝗦𝗙𝗡 𝟮𝟬𝟮𝟰!  Are you also going to Society for Neuroscience (SfN) 2024? Join us at 𝗕𝗼𝗼𝘁𝗵 #𝟰𝟳𝟴 to find out more about the launch of our groundbreaking 𝟮𝟰-𝘄𝗲𝗹𝗹 𝗛𝗗-𝗠𝗘𝗔, featuring the highest number of simultaneously recording wells and electrodes available on the market! This revolutionary system will unlock new research capabilities and elevate your neuroscience studies. Did you know that 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ has many applications in neuroscience research, such as:  • Compound screening / acute and long-term toxicology  • Phenotypic drug assays  • 𝘐𝘯 𝘷𝘪𝘵𝘳𝘰 neuronal and cardiac activity analysis  • Organoid functional maturation  • iPSC neurodegenerative disease characterization  • Neuronal network analysis Join us for a 𝗣𝗿𝗼𝗱𝘂𝗰𝘁 𝗧𝗵𝗲𝗮𝘁𝗿𝗲 𝗧𝗮𝗹𝗸 where you can find out more about our latest product and technology! 𝗧𝗼𝗽𝗶𝗰: CorePlate™: Revolutionizing organoid analysis 𝗪𝗵𝗲𝗻: Sun 6th Oct, 1:00pm CDT 𝗪𝗵𝗲𝗿𝗲: 1500 Aisle (Exhibit Hall) Add it to your calendar: https://lnkd.in/dwCH_fcQ  Find out more on our website: https://bit.ly/3BsrauO #SfN24 #SfN2024

𝗠𝗲𝗱𝘂𝗹𝗹𝗮 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀: 𝗔𝗹𝗶𝘃𝗲 𝗮𝗻𝗱 𝗖𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗻𝗴 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝗡𝗲𝘂𝗿𝗼𝗻𝗮𝗹 𝗖𝗶𝗿𝗰𝘂𝗶𝘁𝗿𝘆 The medulla of the hindbrain plays an essential role in vital bodily functions. Despite this, there has been a lack of 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 models to help study this essential area. Pang et al. in their recent paper generated human medullary organoids which resemble the dorsal domain. Specifically, these organoids displayed similar developmental properties (assessed with transcriptomics) as the spinal trigeminal nucleus (hmSpVOs), a region which normally relays peripheral sensory signals to the thalamus. Following this, Pang et al. fused these organoids with thalamus organoids (hThOs) to form SpV-thalamus organoids to study the projections formed between the two. As part of this, they utilized the 𝗕𝗶𝗼𝗖𝗔𝗠 𝗗𝘂𝗽𝗹𝗲𝘅 with 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ 𝟯𝗗 and electrically stimulated the hmSpVO region of the fused organoid and recorded from the hThO region, finding a significant increase in the mean firing rate of hThO region showing that the two have developed a network and are interconnected. Congratulations to 𝗪𝗲𝗶 𝗣𝗮𝗻𝗴, Yangfei Xiang and the rest of the group on your new publication! For those who would like to learn more about their medulla organoids, check out the paper published on Cell Stem Cell (Cell Press) here: https://bit.ly/3TAA6ED

Are you attending the 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀: 𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝘀 𝗮𝗻𝗱 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀 𝗖𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲? We’d love to meet with you! Stop by to learn how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ can accelerate and enhance your neuronal organoid research. 

𝗛𝘂𝗺𝗮𝗻 𝗶𝗣𝗦𝗖-𝗱𝗲𝗿𝗶𝘃𝗲𝗱 𝗻𝗲𝘂𝗿𝗼𝗻𝗮𝗹 𝗰𝘂𝗹𝘁𝘂𝗿𝗲𝘀 & 𝗕𝗿𝗮𝗶𝗻 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗽𝗿𝗼𝘃𝗶𝗱𝗲 𝗻𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝘁𝗼 𝗔𝘁𝗮𝘅𝗶𝗮 𝗧𝗲𝗹𝗮𝗻𝗴𝗶𝗲𝗰𝘁𝗮𝘀𝗶𝗮.  Ataxia Telangiectasia (AT) is a rare, inherited neurodegenerative disorder characterized by immune deficiencies and ataxia (due to cerebellar degeneration). This condition results from a mutation in the ATM gene which plays a role in DNA damage repair, antioxidant pathways, and maintaining mitochondrial homeostasis. Leeson et al. recently expanded our understanding of AT. Utilizing human iPSC-derived 2D neuronal cultures and brain organoids, they explored mitochondrial function, gene regulatory networks involved in mitochondrial processes, and examined neuronal activity using our 𝗕𝗶𝗼𝗖𝗮𝗺𝗫 platform with 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™. In particular they displayed a reduced sensitivity to glutamate stimulation (assessed by mean firing rate) in AT organoids compared to the isogenic controls which could be rescued by the addition of antioxidants. Congratulations on a fantastic paper Hannah Leeson & Ernst Wolvetang recently published in 𝗡𝗲𝘂𝗿𝗼𝗯𝗶𝗼𝗹𝗼𝗴𝘆 𝗼𝗳 𝗗𝗶𝘀𝗲𝗮𝘀𝗲. A great paper which helps uncover the pathways which cause AT, read their full publication here: https://bit.ly/3XahH2D

𝗛𝗼𝘄 𝗴𝗮𝗽 𝗷𝘂𝗻𝗰𝘁𝗶𝗼𝗻𝘀 𝗵𝗲𝗹𝗽 𝘀𝗵𝗮𝗽𝗲 𝗼𝘂𝗿 𝘃𝗶𝘀𝗶𝗼𝗻? Retinal ganglion cells (RGCs) are the final neuronal output from the retina. They allow for the environmental light information which has been converted by photoreceptors into a neuronal signal, to be transferred to the brain where it is processed as vision. The way in which RGCs signal to the brain is extremely varied, however with the data from Szarka & Voelgyi’s new publication, the role in which - gap junctions play in RGC signaling has become much clearer. By utilizing 3Brain’s 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ technology, a microchip featuring 4096 simultaneously recording electrodes, Szarka et al. were able to record vast amounts of data from mouse retinal explants which had been exposed to different pharmacological compounds, and diverse light conditions to help determine gap junction contributions to signal coding. Congratulations to 𝗚𝗲𝗿𝗴𝗲𝗹𝘆 𝗦𝘇𝗮𝗿𝗸𝗮 & 𝗕𝗲𝗹𝗮 𝗩𝗼𝗲𝗹𝗴𝘆𝗶 on their recent publication featured in iScience – Cell Press, a fascinating paper with extremely useful data for all vision researchers aiming to understand retinal ganglion cell signaling. Check out the publication here: https://bit.ly/4dono3U

𝗖𝗵𝗶𝗺𝗲𝗿𝗶𝗰 𝗼𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀: 𝗮 𝗵𝗶𝗴𝗵-𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁 𝗺𝗼𝗱𝗲𝗹 𝘁𝗼 𝘀𝘁𝘂𝗱𝘆 𝗶𝗻𝘁𝗲𝗿𝗶𝗻𝗱𝗶𝘃𝗶𝗱𝘂𝗮𝗹 𝗿𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀 𝘁𝗼 𝗰𝗼𝗺𝗽𝗼𝘂𝗻𝗱𝘀 Interindividual differences significantly impact disease susceptibility and progression. In this study recently published in 𝗡𝗮𝘁𝘂𝗿𝗲, Noelia Antón Bolaños, Irene Faravelli,  and colleagues developed a model to study individual-specific responses in a high-throughput manner. They developed Chimeroids, a multi-donor cortical #organoid and investigated the effects of neurotoxins. To mitigate donor-specific growth biases, the researchers employed neural stem cell (NSC)-Chimeroids. The functional activity of these NSC-Chimeroids was comparable to standard cortical organoids, as assessed using 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™. Subsequently, NSC-Chimeroids were used to examine individual responses to ethanol, associated with fetal alcoholic syndrome, and valproic acid, associated with an increased risk of autism spectrum disorder. The researchers observed donor-specific responses to ethanol and VPA treatment in Chimeroids. This highlights the model's potential to assess multiple subjects' responses in a single organoid, holding promises for predicting drug efficacy prior to clinical trials. Congratulations to co-authors Noelia Antón Bolaños and Irene Faravelli and Paola Arlotta’s lab on their remarkable achievements! Read the publication here: : https://lnkd.in/eu989Yu2