TEF (gen)

TEF (gen)
Identifikatori
Aliasi	TEF
Vanjski ID-jevi	OMIM: 188595 MGI: 98663 HomoloGene: 31140 GeneCards: TEF
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	41,399,326 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	81,711,064 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • vezivanje sa DNK; • double-stranded DNA binding; • GO:0001948, GO:0016582 vezivanje za proteine; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1950094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • rhythmic process; • transcription by RNA polymerase II; • multicellular organism development;
	Izvori:Amigo / QuickGO
Ortolozi
	7008
	21685
	ENSG00000167074
	ENSMUSG00000022389
	Q10587
	Q9JLC6
	NM_003216; NM_001145398
	NM_017376; NM_153484
	NP_001138870; NP_003207
	NP_059072; NP_705617
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tirotrofni embrionski faktor jest protein koji je kod ljudi kodiran genom TEF sa hromosoma 22.^[5]^[6]^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 303 aminokiseline, a molekulska težina 33.248 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSDAGGGKKP	PVDPQAGPGP	GPGRAAGERG	LSGSFPLVLK	KLMENPPREA
RLDKEKGKEK	LEEDEAAAAS	TMAVSASLMP	PIWDKTIPYD	GESFHLEYMD
LDEFLLENGI	PASPTHLAHN	LLLPVAELEG	KESASSSTAS	PPSSSTAIFQ
PSETVSSTES	SLEKERETPS	PIDPNCVEVD	VNFNPDPADL	VLSSVPGGEL
FNPRKHKFAE	EDLKPQPMIK	KAKKVFVPDE	QKDEKYWTRR	KKNNVAAKRS
RDARRLKENQ	ITIRAAFLEK	ENTALRTEVA	ELRKEVGKCK	TIVSKYETKY
GPL

Funkcija

Tirotrofni embrionskii faktor (TEF), faktor transkripcije, je član potporodikce PAR (aminokiselina bogatih prolinom), transkripcijskih faktora bazne regije/leucinskog zatvarača (bZIP). Kod odraslih životinja, eksprimira se u širokom spektru ćelija i tkiva, ali tokom razvoja ebembriona, izgleda da je ekspresija TEF-a ograničena na razvoj prednjeg režnja hipofiza, što se podudara sa pojavom tiroid-stimulirajućieg hormona beta (TSHB). TEF se može vezati i transaktivirati za TSHB promotor.

Pokazuje homologiju (u funkcionalnim domenima) sa drugim članovima potporodice transkripcionih faktora PAR-bZIP, koji uključuju albumin D-kutija|D-kutijski]]-vezanog proteina (DBP), ljudski faktor jetrene leukemije (HLF) i kokošiji i vitelogenin gen-vezujući protein (VBP); VBP se smatra kokošijim homologom TEF-a. Različiti članovi potporodice mogu lahko formirati heterodimere i dijeliti svojstva vezanja DNK i regulatora transkripcije.^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167074 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022389 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.
^ Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (maj 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood. 105 (11): 4437–44. doi:10.1182/blood-2004-08-2976. PMID 15665112.
^ ^a ^b ^c "Entrez Gene: TEF thyrotrophic embryonic factor".

Dopunska literatura

Drolet DW, Scully KM, Simmons DM, et al. (1991). "TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins". Genes Dev. 5 (10): 1739–53. doi:10.1101/gad.5.10.1739. PMID 1916262.
Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties". Blood. 87 (11): 4607–17. doi:10.1182/blood.V87.11.4607.bloodjournal87114607. PMID 8639829.
Ossipow V, Fonjallaz P, Schibler U (1999). "An RNA Polymerase II Complex Containing All Essential Initiation Factors Binds to the Activation Domain of PAR Leucine Zipper Transcription Factor Thyroid Embryonic Factor". Mol. Cell. Biol. 19 (2): 1242–50. doi:10.1128/mcb.19.2.1242. PMC 116053. PMID 9891058.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Krueger DA, Warner EA, Dowd DR (2000). "Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression". J. Biol. Chem. 275 (19): 14524–31. doi:10.1074/jbc.275.19.14524. PMID 10799536.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167074 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022389 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835883-5] Khatib ZA, Inaba T, Valentine M, Look AT (Feb 1995). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics. 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883.

[pmid15665112-6] Inukai T, Inaba T, Dang J, Kuribara R, Ozawa K, Miyajima A, Wu W, Look AT, Arinobu Y, Iwasaki H, Akashi K, Kagami K, Goi K, Sugita K, Nakazawa S (maj 2005). "TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors". Blood. 105 (11): 4437–44. doi:10.1182/blood-2004-08-2976. PMID 15665112.

[entrez-7] "Entrez Gene: TEF thyrotrophic embryonic factor".

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